SInCRe - Rv1496

Tuberculist information

Gene name	Rv1496
Protein function	Possible transport system kinase
Functional category(tuberculist)	cell wall and cell processes
Gene location(kb)	1686.88
Molecular mass(da)	36256.4
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 334

	  		  	1    MMAASHDDDTVDGLATAVRGGDRAALPRAITLVESTRPDHREQAQQLLLRLLPDSGNAHR   60
			  	61   VGITGVPGVGKSTAIEALGMHLIERGHRVAVLAVDPSSTRTGGSILGDKTRMARLAVHPN  120
			  	121  AYIRPSPTSGTLGGVTRATRETVVLLEAAGFDVILIETVGVGQSEVAVANMVDTFVLLTL  180
			  	181  ARTGDQLQGIKKGVLELADIVVVNKADGEHHKEARLAARELSAAIRLIYPREALWRPPVL  240
			  	241  TMSAVEGRGLAELWDTVERHRQVLTGAGEFDARRRDQQVDWTWQLVRDAVLDRVWSNPTV  300
			  	301  RKVRSELERRVRAGELTPALAAQQILEIANLTDR

Known structures in the PDB

	PDB ID	3MD0
	Total residue count	355
	Number of chains	1
	Method	X-RAY
	Resolution	2.45

	PDB ID	3P32
	Total residue count	355
	Number of chains	1
	Method	X-RAY
	Resolution	1.9

	PDB ID	4GT1
	Total residue count	355
	Number of chains	1
	Method	X-RAY
	Resolution	2

Number of amino acids : 334

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
ArgK	PF03308	26-299

Mtb Structural Proteome models

Model Number	1
Model name	Rv1496_3p32_A
Template	3P32 APDB CREDO
Template coverage	10_333
Template Identity(%)	100.0
Model coverage(%)	96.7
Normalized DOPE score	-1.614

Model Number	2
Model name	Rv1496
Template	1XZP APDB CREDO
Template coverage	159_442
Template Identity(%)	21.1
Model coverage(%)	95.8
Normalized DOPE score	0.631

Structure Models from Chopin

Model Number	1
Profile	c.37.1.10 - 3.40.50.300 Click for model details
zscore	26.63
Residue begin	3
Residue end	334

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1496	Gene name	Confidence Score
Rv1493	mutB	0.999
Rv1493	mutB	0.999
Rv1492	mutA	0.997
Rv1322A	Rv1322A	0.992
Rv1495	mazF4	0.976
Rv1494	mazE4	0.976

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
guanosine diphosphatePubChem	0.978	443.201
triethylene glycolPubChem	0.9	150.173
methylmalonyl-CoAPubChem	0.863	867.607
adenosylcobalaminPubChem	0.86	1580.59
AdoCblPubChem	0.808	1579.58
methylmalonic acidPubChem	0.806	118.088
chloridePubChem	0.773	35.453
succinyl-CoAPubChem	0.755	867.607
propionatePubChem	0.748	74.0785
5'-deoxyadenosylcobalaminPubChem	0.724	1579.58
methylcobalaminPubChem	0.72	1344.38
phosphatePubChem	0.711	96.9872
vitamin B12PubChem	0.708	1354.36
selenomethioninePubChem	0.7	196.106
SeMetPubChem	0.7	196.106
hydron diphosphatePubChem	0.7	391.981