Rv1492

Tuberculist information
Gene namemutA
Protein functionProbable methylmalonyl-CoA mutase small subunit MutA (MCM)
Functional category(tuberculist)lipid metabolism
Gene location(kb)1682.16
Molecular mass(da)64712.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 615
	  		  	1    VSIDVPERADLEQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLLDTQTADGFAIRALYT   60
			  	61   AFDELPEPPLPGQWPFVRGGDPLRDVHSGWKVAEAFPANGATADTNAAVLAALGEGVSAL  120
			  	121  LIRVGESGVAPDRLTALLSGVYLNLAPVILDAGADYRPACDVMLALVAQLDPGQRDTLSI  180
			  	181  DLGADPLTASLRDRPAPPIEEVVAVASRAAGERGLRAITVDGPAFHNLGATAATELAATV  240
			  	241  AAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKMRALRQLWARVAEVVGDPGG  300
			  	301  GAAVVHAETSLPMMTQRDPWVNMLRCTLAAFGAGVGGADTVLVHPFDVAIPGGFPGTAAG  360
			  	361  FARRIARNTQLLLLEESHVGRVLDPAGGSWFVEELTDRLARRAWQRFQAIEARGGFVEAH  420
			  	421  DFLAGQIAECAARRADDIAHRRLAITGVNEYPNLGEPALPPGDPTSPVRRYAAGFEALRD  480
			  	481  RSDHHLARTGARPRVLLLPLGPLAEHNIRTTFATNLLASGGIEAIDPGTVDAGTVGNAVA  540
			  	541  DAGSPSVAVICGTDARYRDEVADIVQAARAAGVSRVYLAGPEKALGDAAHRPDEFLTAKI  600
			  	601  NVVQALSNLLTRLGA

Known structures in the PDB
No Known structures
1 62 123 184 245 306 367 428 489 550 611 Range: 24 to 525  |  Coverage: 81% MM_CoA_mutase Range: 1 to 614  |  Coverage: 99% 1 Range: 1 to 576  |  Coverage: 93% 1 Range: 457 to 615  |  Coverage: 25% 2
Number of amino acids : 615
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MM_CoA_mutasePF0164224-525
Mtb Structural Proteome models
Model Number1
Model nameRv1492
Template1REQ    BPDBCREDO
Template coverage21_635
Template Identity(%)31.9
Model coverage(%)99.7
Normalized DOPE score-0.198

Structure Models from Chopin
Model Number1
Profilec.1.19.1
Click for model details
zscore57.24
Residue begin1
Residue end576
Model Number2
Profile3.40.50.280
Click for model details
zscore13.04
Residue begin457
Residue end615
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1492Gene nameConfidence Score
Rv1493mutB0.998
Rv1493mutB0.998
Rv1496Rv14960.997
Rv1322ARv1322A0.932
Rv0951sucC0.92
Rv0951sucC0.92
Rv0952sucD0.904
Rv0952sucD0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
methylmalonyl-CoAPubChem0.938867.607
succinyl-CoAPubChem0.9867.607
methyl-malonyl-CoAPubChem0.9867.607
methyl-malonyl-coenzyme APubChem0.9862.567
n-propionyl-CoAPubChem0.9823.597
(2S)-methylmalonyl-CoAPubChem0.9867.607
propionatePubChem0.974.0785
methylmalonyl-coenzyme APubChem0.9867.607
succinatePubChem0.9118.088
CHEBI:15466PubChem0.9867.607
H(+)PubChem0.92.01588
carbon dioxidePubChem0.944.0095
suc-coaPubChem0.9867.607
deuteriumPubChem0.92.01588
L-methylmalonyl-CoAPubChem0.9867.607
propionyl-CoAPubChem0.9823.597
protiumPubChem0.92.01576