Rv3028c

Tuberculist information
Gene namefixB
Protein functionProbable electron transfer flavoprotein (alpha-subunit) FixB (alpha-ETF) (electron transfer flavoprotein large subunit) (ETFLS)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3387.07
Molecular mass(da)31691
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 318
	  		  	1    MAEVLVLVEHAEGALKKVSAELITAARALGEPAAVVVGVPGTAAPLVDGLKAAGAAKIYV   60
			  	61   AESDLVDKYLITPAVDVLAGLAESSAPAGVLIAATADGKEIAGRLAARIGSGLLVDVVDV  120
			  	121  REGGVGVHSIFGGAFTVEAQANGDTPVITVRAGAVEAEPAAGAGEQVSVEVPAAAENAAR  180
			  	181  ITAREPAVAGDRPELTEATIVVAGGRGVGSAENFSVVEALADSLGAAVGASRAAVDSGYY  240
			  	241  PGQFQVGQTGKTVSPQLYIALGISGAIQHRAGMQTSKTIVAVNKDEEAPIFEIADYGVVG  300
			  	301  DLFKVAPQLTEAIKARKG

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 3 to 157  |  Coverage: 48% ETF Range: 192 to 277  |  Coverage: 26% ETF_alpha Range: 3 to 314  |  Coverage: 97% 1 Range: 2 to 314  |  Coverage: 98% 1 Range: 190 to 314  |  Coverage: 38% 2 Range: 3 to 157  |  Coverage: 48% 3 Range: 2 to 318  |  Coverage: 99% 4
Number of amino acids : 318
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ETFPF010123-157
ETF_alphaPF00766192-277
Mtb Structural Proteome models
Model Number1
Model nameRv3028c
Template1EFV    APDBCREDO
Template coverage21_331
Template Identity(%)40.2
Model coverage(%)97.8
Normalized DOPE score-0.086

Structure Models from Chopin
Model Number1
Profilec.26.2.3, c.31.1.2 - 3.40.50.1220, 3.40.50.620
Click for model details
zscore50.45
Residue begin2
Residue end314
Model Number2
Profilec.31.1.2
Click for model details
zscore44.1
Residue begin190
Residue end314
Model Number3
Profilec.26.2.3
Click for model details
zscore25.98
Residue begin3
Residue end157
Model Number4
Profilec.26.2.3 - 3.40.50.620
Click for model details
zscore12.09
Residue begin2
Residue end318
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3028cGene nameConfidence Score
Rv3029cfixA0.999
Rv0408pta0.956
Rv0408pta0.956
Rv0408pta0.956
Rv0952sucD0.934
Rv0952sucD0.934
Rv1308atpA0.924
Rv1308atpA0.924
Rv1308atpA0.924
Rv0468fadB20.916
Rv0468fadB20.916
Rv0338cRv0338c0.904
Rv0338cRv0338c0.904
Rv0632cechA30.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.986785.55
adenosine monophosphatePubChem0.977347.221
1,5-dihydro-FADPubChem0.9787.566
SeMetPubChem0.738196.106
selenomethioninePubChem0.738196.106
trimethylaminePubChem0.71559.1103
ganglioside GM2PubChem0.7061384.68