Rv0338c

Tuberculist information
Gene nameRv0338c
Protein functionProbable iron-sulfur-binding reductase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)403.193
Molecular mass(da)95453.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 882
	  		  	1    VTTQTLIRLILGMSMTAVVGVFALRRVWWLYKLVMSGQPASGRTDNLGTRIWTQISEVLG   60
			  	61   QRRLLKWSIPGLAHFFTMWGFFILLTVYIEAYGLLFEERFHIPVIGRWDALGFLQDFFAT  120
			  	121  AVFLGITTFAIIRILRNPREIGRSSRFYGSHNGGAWLVLLMIFNVIWTYVLVRGSAVNNG  180
			  	181  TLPYGNGAFLSQLFGAILRPLGQPANEIIETTALLLHIGVMLAFLILVLHSKHLHIFLAP  240
			  	241  INVTFKRLPDGLGPLLPLEADGKPIDFENPSEDAVFGRGKIEDFTWKGMLDFATCTECGR  300
			  	301  CQSQCPAWNTGKPLSPKLVIMDLRDHWMAKAPYILGQKDASAGGEAGHQEHHHVPESGFG  360
			  	361  RVPGHGPEQATRPLVGTEEQGGVIDPDVLWSCVTCGACVEQCPVDIEHVDHIVDMRRYQV  420
			  	421  MMESEFPSELSVLFKNLETKGNPWGQNASDRTNWIDEVDFDVPVYGQDVDSFDGYEYLFW  480
			  	481  VGCAGAYDDKAKKTTKAVAELLAVARVKYLVLGAGETCNGDSARRSGNEFLFQQLAQQAV  540
			  	541  ETLDGLFEGVETVDRKIVVTCPHCFNTIGKEYRQLGANYTVLHHTQLLNRLVRDKRLVPV  600
			  	601  TPVSQDITYHDPCYLGRHNKAYEAPRELIGAAGASLTEMPRHADRSFCCGAGGARMWMEE  660
			  	661  HIGKRINHERVDEALATDATAIATACPFCRVMVTDGVNDRQEEAGRSGVEVLDVAQVLLG  720
			  	721  SLDHDKAQLPAKGTAAKQAQERAPKAAPKAAAPVTPVEAPAEAPQAPAPAAPAAPVKGLG  780
			  	781  MAAGAKRPGAKKAAPTPAAPAAPAAPVKGLGIAAGAKRPGAKKTPPPAPGLAEPAAQPQP  840
			  	841  EAKPQPEPAAPPKPQTDGDPAAPAAPVKGLGIARGARPPGKR

Known structures in the PDB
No Known structures
1 89 177 265 353 441 529 617 705 793 881 Range: 291 to 406  |  Coverage: 13% Fer4_8 Range: 477 to 569  |  Coverage: 10% CCG Range: 607 to 694  |  Coverage: 9% CCG Range: 5 to 249  |  Coverage: 27% 1
Number of amino acids : 882
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Fer4_8PF13183291-406
CCGPF02754477-569
CCGPF02754607-694
Mtb Structural Proteome models
Model Number1
Model nameRv0338c
Template1Q16    CPDBCREDO
Template coverage2_219
Template Identity(%)14.3
Model coverage(%)27.7
Normalized DOPE score1.038

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0338cGene nameConfidence Score
Rv3029cfixA0.909
Rv3028cfixB0.904
Rv3028cfixB0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Target nameCHEMBL IDSMILES
Beta-cateninc1ccc(cc1)Oc2ccccc2C(=O)[O-]
Beta-cateninCC[C@@]1(C)CCC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C[C@H](OC(=O)C)[C@@]4(C)[C@H]3CC(=O)C5=C4C(=O)OC5C
Beta-cateninC/1(N(C(/C=2/C(=N1)/N(/N=C\N2)C)=O)C)=O
Beta-cateninc1c(c(ccc1)C(=O)N\N=C\c1oc(cc1)C)Oc1ccccc1
Beta-cateninCc1oc(C=NNC(=O)c2ccccc2Oc3ccccc3)cc1
Beta-cateninCC[C@@]1(C)CCC[C@@]2(C)[C@H]1CC[C@@]3(C)[C@@H]4CC=C([C@@H]5[C@H](O)C[C@]45[C@H](C[C@H]23)OC(=O)C)C(=O)C
Beta-cateninc12c3c4c(cc(c5c4c(c\4c3c(c(c1)O)C(\C(=C4\C[C@H](C)O)\OC)=O)/C(=C(\C5=O)/OC)/C[C@H](C)O)O)OCO2
Beta-cateninCC[C@@]1(C)CCC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C[C@H](OC(=O)C)[C@@]4(C)[C@H]3CC=C([C@@H]4C(=O)O)C(=O)C
Beta-cateninCc1c(Br)cc2C(=C3C=C(Br)C(=O)C(=C3Oc2c1Br)Br)c4ccccc4C(=O)O
Beta-cateninCC[C@@]1(C)CCC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C[C@H](OC(=O)C)[C@]4(C)[C@@H](O)C(=CC[C@@H]34)C(=O)C
Beta-cateninc1ccc(c(c1)C2=C3C=CC(=O)C=C3Oc4c2ccc(c4)[O-])C(=O)[O-]
Beta-cateninCC[C@@]1(C)CCC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C[C@H](OC(=O)C)[C@]4(C)C5=C(C(=O)C=C34)C(C)(O)OC5=O
Beta-cateninCC[C@@]1(C)CCC[C@@]2(C)[C@H]1CC[C@@]3(C)[C@@H]4CC=C([C@@H]5[C@@H](O)C[C@]45[C@H](C[C@H]23)OC(=O)C)C(=O)C
Beta-cateninc1(cccc2c1C(C(c1c2cc(c(c1O)C)C(CCC)=O)=O)=O)O
Beta-cateninCCC(O)CC(=O)O[C@@H]1C[C@H]2[C@]3(C)CC[C@H]4[C@@](C)(CC)CCC[C@]4(C)[C@H]3C[C@H](OC(=O)C)[C@]2(C)[C@H]([C@@H]1C(=O)C)C(=O)O
BRD4CN1Cc2cc(NS(=O)(=O)c3ccccc3F)ccc2NC1=O
BRD4Cc1sc2c(C(=N[C@@H](CC(=O)OC(C)(C)C)c3nnc(C)n23)c4ccc(Cl)cc4)c1C
BRD4CN1N=C(c2ccccc2)c3cc(Cl)ccc3n4c(N)nnc14
BRD4Cc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4n12
BRD4CCC1=NCc2nnc(c3ccncc3)n2c4ccc(Cl)cc14
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)Nc3ccccc3Cl
BRD4CN1N=C(c2ccccc2)c3cc(Cl)ccc3N=C1NNC(=O)C
BRD4Cc1nnc2[C@H](NC(=O)OCc3ccccc3)N=C(c3ccccc3)c3ccccc3-n12
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NCCc3ccccc3
BRD4CCOc1cccc(c1)c2c(C)onc2C
BRD4CN1N=C(c2ccccc2)c3cc(Cl)ccc3NC1=S
BRD4Cc1onc(C)c1c2ccc(OCCN3CCNCC3)c(c2)S(=O)(=O)NC4CCCC4
BRD4CN1N=C(c2ccccc2)c3cc(Cl)ccc3n4c(C)nnc14
BRD4CCC1=NCC(=S)Nc2ccc(Cl)cc12
BRD4Cc1onc(C)c1c2ccc(OCCCN3CCOCC3)c(c2)S(=O)(=O)NC4CCCC4
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NCCCO
BRD4COCCNS(=O)(=O)c1cc(ccc1C)c2c(C)onc2C
BRD4Cc1onc(C)c1c2ccc(O)c(c2)S(=O)(=O)NC3CCCC3
BRD4CCOc1cc(cc(c1)c2c(C)onc2C)C(C)O
BRD4COc1ccc(NS(=O)(=O)c2cc(ccc2C)c3c(C)onc3C)cc1
BRD4COc1ccc(cc1S(=O)(=O)Nc2ccccc2)c3c(C)onc3C
BRD4CN1Cc2cc(ccc2NC1=O)S(=O)(=O)N3CCCC3
BRD4CN1Cc2cc(ccc2NC1=O)S(=O)(=O)Nc3ccccc3
BRD4CCNS(=O)(=O)c1cc(ccc1C)c2c(C)onc2C
BRD4CN1Cc2cc(Br)ccc2NC1=O
BRD4CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c3ccc(OC)cc3n4c(C)nnc14
BRD4COc1ccccc1S(=O)(=O)Nc2ccc3NC(=O)N(C)Cc3c2
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC(C)(C)C
BRD4COc1ccc(cc1S(=O)(=O)NCc2ccccc2)c3c(C)onc3C
BRD4CCOC(=O)c1ncn2c1[C@@H]3CCCN3C(=O)c4cc(OC)ccc24
BRD4COc1ccc(cc1)S(=O)(=O)Nc2ccc3NC(=O)N(C)Cc3c2
BRD4COc1ccc(cc1S(=O)(=O)NC2CCCC2)c3c(C)onc3C
BRD4CN1Cc2cc(NS(=O)(=O)c3ccc(C)cc3)ccc2NC1=O
BRD4CN1CCCC1=O
BRD4CN1Cc2cc(NS(=O)(=O)c3ccccc3C)ccc2NC1=O
BRD4CN1Cc2cc(ccc2NC1=O)c3c(C)onc3C
BRD4CN1Cc2ccccc2NC1=O
BRD4Clc1ccc2N3C=NNC3=CN=C(c4ccccc4)c2c1
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC3CCCC3
BRD4Cc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4n12
BRD4Cc1nnc2C(NC(=O)OCc3ccccc3)N=C(c4ccccc4)c5ccccc5n12
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)Nc3cccc(Cl)c3
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)N3CCOCC3
BRD4CCC1=NCc2nnc(C)n2c3ccc(Cl)cc13
BRD4CC(O)c1cccc(c1)c2c(C)onc2C
BRD4CCC1=NCc2nnc(c3ccccc3)n2c4ccc(Cl)cc14
BRD4Cc1onc(C)c1c2ccccc2
BRD4CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c3cc(OC)ccc3n4c(C)nnc14
BRD4COCCN(CC(=O)N(CCCCN)CC(=O)N(CCCCN)CC(=O)N)C(=O)CN(CCCCN)C(=O)CN(CCc1ccc(O)cc1)C(=O)CNCC(C)C
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)Nc3ccc(Cl)cc3
BRD4CCC1=NCc2nnc(c3cccc(OC)c3)n2c4ccc(Cl)cc14
BRD4CC(=O)c1cccc(c1)c2c(C)onc2C
BRD4CC1CCc2ccccc2N1C(=O)C
BRD4CN1Cc2cc(NS(=O)(=O)c3ccccc3C(F)(F)F)ccc2NC1=O
BRD4CCC1=NCC(=O)Nc2ccc(Cl)cc12
BRD4CC(=O)Nc1ccc(O)cc1
BRD4CC(C)CN(CC(=O)N(CCCCN)CC(=O)N(CC(=O)N(CCCCN)CC(=O)N(CCCCN)CC(=O)N)Cc1occc1)C(=O)CNCCCN2CCCC2=O
BRD4COc1ccc(cc1S(=O)(=O)NC2CCCNC2)c3c(C)onc3C
BRD4Cc1nnc2[C@H](NC(=O)OCc3ccccc3)N=C(c4ccccc4)c5ccccc5n12
BRD4COc1ccc(cc1S(=O)(=O)NC2CCNCC2)c3c(C)onc3C
BRD4COc1cccc(c1)S(=O)(=O)Nc2ccc3NC(=O)N(C)Cc3c2
BRD4CC(=O)c1cc(c2ccccn2)c3ccccn13
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC3CCNCC3
BRD4CCOC(=O)c1cc(OCC)cc(c1)c2c(C)onc2C
BRD4CN1Cc2cc(ccc2N(C)C1=O)S(=O)(=O)N3CCOCC3
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)N3CCCC3
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)N3CCNCC3
BRD4COc1ccccc1NS(=O)(=O)c2cc(ccc2C)c3c(C)onc3C
BRD4COc1ccc(cc1S(=O)(=O)N2CCNCC2)c3c(C)onc3C
BRD4Cc1onc(C)c1c2cccc(c2)S(=O)(=O)NC3CC3
BRD4CCN(C1CCCC1)S(=O)(=O)c2cc(ccc2OC)c3c(C)onc3C
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NCCCc3ccccc3
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)N
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NCc3ccccc3
BRD4COc1ccc(cc1S(=O)(=O)Nc2ccccc2Cl)c3c(C)onc3C
BRD4CN1Cc2cc(NS(=O)(=O)c3ccc(F)cc3Cl)ccc2NC1=O
BRD4COc1ccc(NS(=O)(=O)c2cc(ccc2OC)c3c(C)onc3C)cc1
BRD4CN1Cc2cc(NS(=O)(=O)c3ccc(cc3)C#N)ccc2NC1=O
BRD4CCOc1cc(cc(c1)c2c(C)onc2C)C(=O)O
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC3CC3
BRD4COc1cccc(NS(=O)(=O)c2cc(ccc2OC)c3c(C)onc3C)c1
BRD4CN1N=C(c2ccccc2)c3cc(Cl)ccc3N4C(=O)NN=C14
BRD4COc1ccc(cc1S(=O)(=O)NC2CC2)c3c(C)onc3C
BRD4CCOc1cc(cc(c1)c2c(C)onc2C)C(=O)C
BRD4Cc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4n12
BRD4COc1ccc(cc1S(=O)(=O)N2CCOCC2)c3c(C)onc3C
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)N3CCCCC3
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC3CCCNC3
BRD4COc1ccccc1NS(=O)(=O)c2cc(ccc2OC)c3c(C)onc3C
BRD4CCNS(=O)(=O)c1ccc2NC(=O)N(C)Cc2c1
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)NC3CCCCC3
BRD4CCC1=NCc2nnc(CC)n2c3ccc(Cl)cc13
BRD4CN1Cc2cc(NS(=O)(=O)c3ccccc3)ccc2NC1=O
BRD4COc1ccc(cc1S(=O)(=O)N(C)C2CCCC2)c3c(C)onc3C
BRD4Cc1onc(C)c1c2ccc(C)c(c2)S(=O)(=O)Nc3ccccc3
BRD4COc1cccc(NS(=O)(=O)c2cc(ccc2C)c3c(C)onc3C)c1
ClathrinBrc4ccc(C=c3sc(NS(=O)(=O)c1cccc2ccccc12)nc3=O)cc4
Clathrinc1cc2cc(cc3c2c(c1)C(=O)N(C3=O)Cc4ccc(cc4)N)S(=O)(=O)O
ZipAc1(c(cc2c(c1)N1\C(=C(/N2)\C)\C(=C(/C1=O)\CC(=O)O)\C)Cl)Cl
ZipAc1ccc2c(c1)c1c3n2C(C[C@@]2([C@@]3(N(CC1)CCC2)[H])[H])=O
ZipAc1(nc(oc1c1ccccc1)CCC(=O)O)c1ccccc1
ZipAc1cc(cc(n1)N1CCN(CC1)CCN)c1ccnc(n1)Nc1ccc(c(c1)Cl)C
ZipAc1ccc2c(c1)n(c1c2cnn2c1nnc2)C
ZipACc1ccc(Nc2nccc(n2)c3ccnc(c3)N4CCN(CCN)CC4)cc1Cl
ZipAc1ccc2c(c1)c1c(n2CCCN)c2c(CC1)cccc2
ZipAc1ccc2c(c1)cc(n2CCCN)C1CCCN(C1)C(c1ccc(cc1)c1ccccc1)=O
ZipAc1ccc2c(c1)cc1n2c2[n+](c3c1cccc3)CCC2
ZipAc1ccc2c(c1)c1c(n2CCCNS(=O)(=O)C(C)C)C2N(CC1=O)CCCC2
ZipAc1ccc2c(c1)c1c([nH]2)C2N(CC1=O)CCCC2
ZipAc1c(cc2c(c1)c(c1c(n2)ccc(c1)OC)NC(CCCO)C)Cl
ZipAc1ccc2c(c1)n(c1c2CCc2c1cccc2)CCCN
ZipAc1ccc2c(c1)cc(n2CCC(=O)NCCN1CCCC1)c1cccc(c1)Cl
ZipAc1ccc2c(c1)c(c([nH]2)c1ccccc1)c1cccc(c1)c1cccc(c1)C(=O)O
ZipAc1cc(cc(c1)N(C(C)=O)C)c1nnc2n1nc(cc2)c1ccccc1
ZipAc1ccc2c(c1)c1c(C2=O)nc2c(n1)cccn2
ZipAn1nnn(c1CC)C/C(=N/Nc1ccccn1)/C
ZipACN(C(=O)C)c1cccc(c1)c2nnc3ccc(nn23)c4ccccc4
ZipAc1ccc2c(c1)c(n[nH]2)c1ccncc1
ZipAc1ccc2c(c1)cc(nc2N)c1ncccc1
ZipAc1ccc2c(c1)[nH]c1c2[C@H](CO[C@]1(CC)CC(O)=O)C(=O)c1ccccc1
ZipAc1cc(nc(n1)c1ccncc1)c1sccc1
STITCH interactions  
No high confidence interactions