Rv0573c

Tuberculist information
Gene namepncB2
Protein functionNicotinic acid phosphoribosyltransferase PncB2
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)665.851
Molecular mass(da)50508.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 463
	  		  	1    MAIRQHVGALFTDLYEVTMAQAYWAERMSGTAVFEIFFRKLPPGRSYIMAAGLADVVEFL   60
			  	61   EAFRFDEQDLRYLRGLGQFSDEFLRWLAGVRFTGDVWAAPEGTVIFPNEPAVQLIAPIIE  120
			  	121  AQLVETFVLNQIHLQSVLASKAARVVAAARGRPVVDFGARRAHGTDAACKVARTSYLAGA  180
			  	181  AGTSNLLAARQYGIPTFGTMAHSFVQAFDSEVAAFEAFARLYPATMLLVDTYDTLRGVDH  240
			  	241  VIELAKRLGNRFDVRAVRLDSGDLDELSKATRARLDTAGLEQVEIFASSGLDENRIAALL  300
			  	301  AARCPIDGFGVGTQLVVAQDAPALDMAYKLVAYDGSGRTKFSSGKVIYPGRKQVFRKLEH  360
			  	361  GVFCGDTLGEHGENLPGDPLLVPIMTNGRRIRQHAPTLDGARDWARQQIDALPPELRSLE  420
			  	421  DTGYSYPVAVSDRIVGELARLRHADTAEAHPGSNVVGAKAKRP

Known structures in the PDB
No Known structures
1 47 93 139 185 231 277 323 369 415 461 Range: 153 to 345  |  Coverage: 41% NAPRTase Range: 2 to 462  |  Coverage: 99% 1 Range: 1 to 447  |  Coverage: 96% 1 Range: 1 to 139  |  Coverage: 29% 2
Number of amino acids : 463
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NAPRTasePF04095153-345
Mtb Structural Proteome models
Model Number1
Model nameRv0573c
Template2F7F    APDBCREDO
Template coverage4_482
Template Identity(%)37.3
Model coverage(%)99.4
Normalized DOPE score-0.187

Structure Models from Chopin
Model Number1
Profile3.20.140.10
Click for model details
zscore33.08
Residue begin1
Residue end447
Model Number2
Profiled.41.2.1
Click for model details
zscore18.01
Residue begin1
Residue end139
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0573cGene nameConfidence Score
Rv2421cnadD0.989
Rv2043cpncA0.988
Rv1596nadC0.97
Rv1596nadC0.97
Rv3307deoD0.939
Rv0574cRv0574c0.93
Rv1330cpncB10.925
Rv3199cnudC0.92
Rv3199cnudC0.92
Rv3199cnudC0.92
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
nicotinic acidPubChem0.981122.101
pyrophosphatePubChem0.962177.975
nicotinic acid mononucleotidePubChem0.953336.212
nicotinate mononucleotidePubChem0.945335.204
phosphoribosylpyrophosphatePubChem0.934390.07
H(+)PubChem0.92.01588
deuteriumPubChem0.92.01588