Rv3199c

Tuberculist information
Gene namenudC
Protein functionProbable NADH pyrophosphatase NudC (NAD+ diphosphatase) (NAD+ pyrophosphatase) (NADP pyrophosphatase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3571.6
Molecular mass(da)33794.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 313
	  		  	1    VTNVSGVDFQLRSVPLLSRVGADRADRLRTDMEAAAAGWPGAALLRVDSRNRVLVANGRV   60
			  	61   LLGAAIELADKPPPEAVFLGRVEGGRHVWAVRAALQPIADPDIPAEAVDLRGLGRIMDDT  120
			  	121  SSQLVSSASALLNWHDNARFSALDGAPTKPARAGWSRVNPITGHEEFPRIDPAVICLVHD  180
			  	181  GADRAVLARQAAWPERMFSLLAGFVEAGESFEVCVAREIREEIGLTVRDVRYLGSQQWPF  240
			  	241  PRSLMVGFHALGDPDEEFSFSDGEIAEAAWFTRDEVRAALAAGDWSSASESKLLLPGSIS  300
			  	301  IARVIIESWAACE

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 42 to 134  |  Coverage: 29% NUDIX-like Range: 136 to 167  |  Coverage: 9% zf-NADH-PPase Range: 170 to 295  |  Coverage: 39% NUDIX Range: 46 to 311  |  Coverage: 84% 1 Range: 170 to 295  |  Coverage: 39% 1 Range: 143 to 313  |  Coverage: 54% 2
Number of amino acids : 313
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NUDIX-likePF0929642-134
zf-NADH-PPasePF09297136-167
NUDIXPF00293170-295
Mtb Structural Proteome models
Model Number1
Model nameRv3199c
Template1VK6    APDBCREDO
Template coverage14_250
Template Identity(%)29.5
Model coverage(%)84.7
Normalized DOPE score0.814

Structure Models from Chopin
Model Number1
Profiled.113.1.2 - 3.90.79.10
Click for model details
zscore12.91
Residue begin170
Residue end295
Model Number2
Profiled.113.1.2 - 3.90.79.10
Click for model details
zscore8.18
Residue begin143
Residue end313
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3199cGene nameConfidence Score
Rv1330cpncB10.942
Rv0573cpncB20.92
Rv3200cRv3200c0.91
Rv3200cRv3200c0.91
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.925663.425
nicotinamide nucleotidePubChem0.902335.227
nicotinate mononucleotidePubChem0.9335.204
nicotinic acid mononucleotidePubChem0.9336.212
nicotinic acid adenine dinucleotidePubChem0.9665.418