Rv1330c

Tuberculist information
Gene namepncB1
Protein functionNicotinic acid phosphoribosyltransferase PncB1
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1499.21
Molecular mass(da)47194.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 448
	  		  	1    VGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRY   60
			  	61   GVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLREFRFRGDIDGYAEGELYFPGS  120
			  	121  PVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAAGGRPLIEMGSRRTHERAAVA  180
			  	181  AARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEAL  240
			  	241  GPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIV  300
			  	301  VSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESP  360
			  	361  GGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLPLVRAGQPVADTSLAAARQLV  420
			  	421  ASGLRSLPGDGLKLAPGEPAIPTRTIPA

Known structures in the PDB
No Known structures
1 45 89 133 177 221 265 309 353 397 441 Range: 164 to 377  |  Coverage: 47% NAPRTase Range: 17 to 446  |  Coverage: 95% 1 Range: 2 to 379  |  Coverage: 84% 1 Range: 13 to 150  |  Coverage: 30% 2
Number of amino acids : 448
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NAPRTasePF04095164-377
Mtb Structural Proteome models
Model Number1
Model nameRv1330c
Template2F7F    APDBCREDO
Template coverage7_465
Template Identity(%)31.9
Model coverage(%)95.8
Normalized DOPE score-0.073

Structure Models from Chopin
Model Number1
Profile3.20.140.10
Click for model details
zscore33.9
Residue begin2
Residue end379
Model Number2
Profiled.41.2.1
Click for model details
zscore17.57
Residue begin13
Residue end150
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1330cGene nameConfidence Score
Rv2421cnadD0.985
Rv2043cpncA0.983
Rv3199cnudC0.942
Rv3199cnudC0.942
Rv3199cnudC0.942
Rv1596nadC0.935
Rv1596nadC0.935
Rv0573cpncB20.925
Rv3307deoD0.912
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
nicotinic acidPubChem0.955122.101
nicotinic acid mononucleotidePubChem0.938336.212
nicotinate mononucleotidePubChem0.934335.204
pyrophosphatePubChem0.922177.975
phosphoribosylpyrophosphatePubChem0.914390.07
H(+)PubChem0.92.01588
deuteriumPubChem0.92.01588