Rv1594

Tuberculist information
Gene namenadA
Protein functionProbable quinolinate synthetase NadA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1794.76
Molecular mass(da)37408.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 349
	  		  	1    MTVLNRTDTLVDELTADITNTPLGYGGVDGDERWAAEIRRLAHLRGATVLAHNYQLPAIQ   60
			  	61   DVADHVGDSLALSRVAAEAPEDTIVFCGVHFMAETAKILSPHKTVLIPDQRAGCSLADSI  120
			  	121  TPDELRAWKDEHPGAVVVSYVNTTAAVKALTDICCTSSNAVDVVASIDPDREVLFCPDQF  180
			  	181  LGAHVRRVTGRKNLHVWAGECHVHAGINGDELADQARAHPDAELFVHPECGCATSALYLA  240
			  	241  GEGAFPAERVKILSTGGMLEAAHTTRARQVLVATEVGMLHQLRRAAPEVDFRAVNDRASC  300
			  	301  KYMKMITPAALLRCLVEGADEVHVDPGIAASGRRSVQRMIEIGHPGGGE

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 35 to 342  |  Coverage: 87% NadA Range: 34 to 342  |  Coverage: 88% 1 Range: 32 to 342  |  Coverage: 88% 1
Number of amino acids : 349
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NadAPF0244535-342
Mtb Structural Proteome models
Model Number1
Model nameRv1594
Template1WZU    APDBCREDO
Template coverage3_298
Template Identity(%)42.4
Model coverage(%)88.3
Normalized DOPE score-0.058

Structure Models from Chopin
Model Number1
Profilec.145.1.1
Click for model details
zscore49.91
Residue begin32
Residue end342
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1594Gene nameConfidence Score
Rv1595nadB0.999
Rv1595nadB0.999
Rv1596nadC0.999
Rv1596nadC0.999
Rv1593cRv1593c0.961
Rv3601cpanD0.941
Rv3602cpanC0.919
Rv2225panB0.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
iminoaspartatePubChem0.992131.087
dihydroxyacetone phosphatePubChem0.986170.058
quinolinic acidPubChem0.985167.119
aspartatePubChem0.96133.103
hydrogen peroxidePubChem0.95734.0147
nicotinic acid mononucleotidePubChem0.956336.212
phosphoribosylpyrophosphatePubChem0.922390.07
phosphatePubChem0.90396.9872
protiumPubChem0.92.01576
molecular oxygenPubChem0.931.9988
pyrophosphatePubChem0.9177.975
H(+)PubChem0.92.01588
nicotinate mononucleotidePubChem0.9335.204
carbon dioxidePubChem0.944.0095
hydroxyl radicalsPubChem0.917.0073
potassium aspartatePubChem0.9133.103
deuteriumPubChem0.92.01588
4Fe-4SPubChem0.8488.9179
NAD+PubChem0.796663.425
malatePubChem0.703134.087
D-malatePubChem0.703134.087