SInCRe - Rv0337c

Tuberculist information

Gene name	aspC
Protein function	Probable aspartate aminotransferase AspC (transaminase A) (ASPAT)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	401.873
Molecular mass(da)	47318
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 429

	  		  	1    VDNDGTIVDVTTHQLPWHTASHQRQRAFAQSAKLQDVLYEIRGPVHQHAARLEAEGHRIL   60
			  	61   KLNIGNPAPFGFEAPDVIMRDIIQALPYAQGYSDSQGILSARRAVVTRYELVPGFPRFDV  120
			  	121  DDVYLGNGVSELITMTLQALLDNGDQVLIPSPDYPLWTASTSLAGGTPVHYLCDETQGWQ  180
			  	181  PDIADLESKITERTKALVVINPNNPTGAVYSCEILTQMVDLARKHQLLLLADEIYDKILY  240
			  	241  DDAKHISLASIAPDMLCLTFNGLSKAYRVAGYRAGWLAITGPKEHASSFIEGIGLLANMR  300
			  	301  LCPNVPAQHAIQVALGGHQSIEDLVLPGGRLLEQRDIAWTKLNEIPGVSCVKPAGALYAF  360
			  	361  PRLDPEVYDIDDDEQLVLDLLLSEKILVTQGTGFNWPAPDHLRLVTLPWSRDLAAAIERL  420
			  	421  GNFLVSYRQ

Known structures in the PDB

No Known structures

Number of amino acids : 429

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Aminotran_1_2	PF00155	57-420

Mtb Structural Proteome models

Model Number	1
Model name	Rv0337c
Template	1XI9 APDB CREDO
Template coverage	4_394
Template Identity(%)	36.7
Model coverage(%)	90.4
Normalized DOPE score	-0.687

Structure Models from Chopin

Model Number	1
Profile	c.67.1.1 Click for model details
zscore	34.71
Residue begin	1
Residue end	429

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv0337c	Gene name	Confidence Score
Rv1240	mdh	0.948
Rv1240	mdh	0.948
Rv3423c	alr	0.94
Rv3423c	alr	0.94
Rv0189c	ilvD	0.939
Rv2967c	pca	0.93
Rv2967c	pca	0.93
Rv2967c	pca	0.93
Rv2967c	pca	0.93
Rv2967c	pca	0.93
Rv2967c	pca	0.93
Rv3709c	ask	0.927
Rv3709c	ask	0.927
Rv3709c	ask	0.927
Rv1595	nadB	0.911
Rv1595	nadB	0.911
Rv2448c	valS	0.904
Rv2448c	valS	0.904
Rv2448c	valS	0.904

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
alpha-ketoglutaratePubChem	0.961	146.098
L-alaninePubChem	0.946	89.0932
glutamatePubChem	0.93	147.129
aspartatePubChem	0.928	133.103
phosphatePubChem	0.925	96.9872
ammoniaPubChem	0.921	17.0305
fumaratePubChem	0.921	116.072
oxaloacetatePubChem	0.907	132.072
adenosine diphosphatePubChem	0.907	427.201
adenosine triphosphatePubChem	0.905	507.181
malatePubChem	0.903	134.087
deuteriumPubChem	0.903	2.01588
NAD+PubChem	0.9	663.425
beta-aspartyl phosphatePubChem	0.9	213.083
bicarbonatePubChem	0.9	62.0248
hydrogen peroxidePubChem	0.9	34.0147
H(+)PubChem	0.9	2.01588
pyruvic acidPubChem	0.9	88.0621
aspartyl phosphatePubChem	0.9	213.083
D-malatePubChem	0.9	134.087
reduced nicotinamide adenine dinucleotidePubChem	0.9	665.441
protiumPubChem	0.9	2.01576
molecular oxygenPubChem	0.9	31.9988
potassium aspartatePubChem	0.9	133.103
iminoaspartatePubChem	0.9	131.087
dihydronicotinamide formycin dinucleotidePubChem	0.9	665.441
pyridoxal phosphatePubChem	0.788	247.142
Ge-132PubChem	0.785	339.419