Rv2139

Tuberculist information
Gene namepyrD
Protein functionProbable dihydroorotate dehydrogenase PyrD
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2398.72
Molecular mass(da)37998.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 357
	  		  	1    MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVRRLLRRLLGPTDPVLASTVFGVRFPA   60
			  	61   PLGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFN  120
			  	121  NHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYRASARMVGPLASYLVVNVSSP  180
			  	181  NTPGLRDLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAGIVAT  240
			  	241  NTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISVGGIETADDA  300
			  	301  WERITAGASLLQGYTGFIYGGERWAKDIHEGIARRLHDGGFGSLHEAVGSARRRQPS

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 48 to 336  |  Coverage: 80% DHO_dh Range: 3 to 354  |  Coverage: 98% 1 Range: 1 to 357  |  Coverage: 99% 1
Number of amino acids : 357
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DHO_dhPF0118048-336
Mtb Structural Proteome models
Model Number1
Model nameRv2139
Template1D3G    APDBCREDO
Template coverage41_396
Template Identity(%)41.8
Model coverage(%)98.3
Normalized DOPE score-0.832

Structure Models from Chopin
Model Number1
Profilec.1.4.1 - 3.20.20.70
Click for model details
zscore31.49
Residue begin1
Residue end357
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2139Gene nameConfidence Score
Rv1383carA0.999
Rv0382cpyrE0.999
Rv1383carA0.999
Rv1384carB0.996
Rv1384carB0.996
Rv1380pyrB0.996
Rv1384carB0.996
Rv1380pyrB0.996
Rv1384carB0.996
Rv1381pyrC0.993
Rv1379pyrR0.991
Rv1385pyrF0.991
Rv0772purD0.969
Rv3309cupp0.969
Rv0772purD0.969
Rv0772purD0.969
Rv0957purH0.965
Rv0957purH0.965
Rv1699pyrG0.956
Rv1699pyrG0.956
Rv3396cguaA0.954
Rv3396cguaA0.954
Rv3396cguaA0.954
Rv0808purF0.948
Rv0808purF0.948
Rv0956purN0.943
Rv1017cprsA0.937
Rv1017cprsA0.937
Rv3275cpurE0.933
Rv2883cpyrH0.924
Rv1656argF0.916
Rv1656argF0.916
Rv1658argG0.914
Rv1389gmk0.913
Rv1599hisD0.908
Rv0809purM0.904
Rv0809purM0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
orotic acidPubChem0.995156.096
dihydroorotatePubChem0.994158.112
flavin mononucleotidePubChem0.991456.344
dihydroorotic acidPubChem0.986158.112
brequinar sodiumPubChem0.941375.367
molecular oxygenPubChem0.93231.9988
leflunomidePubChem0.92270.207
hydrogen peroxidePubChem0.91634.0147
ubiquinol-1PubChem0.9252.306
ubiquinonesPubChem0.9250.29
A77 1726PubChem0.894270.207
S-8660PubChem0.812373.832
U0126PubChem0.784380.49
cyanocyclopropylpropenamide, 4PubChem0.778296.245
FPIPubChem0.775113.158
HR325PubChem0.764310.271
biphenyl compound 13PubChem0.763292.332
DB03805PubChem0.763272.223
sulfatePubChem0.76396.0626
hydron sulfatePubChem0.763196.157
cyanohydroxybutenamide, 17PubChem0.743347.195
cyanohydroxybutenamide, 18PubChem0.739380.748
DB08172PubChem0.736342.776
DB08169PubChem0.736304.343
ILBPubChem0.734427.321
cyanohydroxybutenamide, 20PubChem0.734381.64
CHEBI:357152PubChem0.73463.302
cyanohydroxybutenamide, 26PubChem0.724347.195
DB07443PubChem0.724278.305
cyanohydroxybutenamide, 27PubChem0.718312.75
cyanohydroxybutenamide, 28PubChem0.718312.75
DB07561PubChem0.705322.358
DB07559PubChem0.705347.195
acetatePubChem0.70259.044
cyanohydroxybutenamide, 25PubChem0.702347.195