Rv1605

Tuberculist information
Gene namehisF
Protein functionProbable cyclase HisF
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1804.85
Molecular mass(da)27220.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 267
	  		  	1    MYADRDLPGAGGLAVRVIPCLDVDDGRVVKGVNFENLRDAGDPVELAAVYDAEGADELTF   60
			  	61   LDVTASSSGRATMLEVVRRTAEQVFIPLTVGGGVRTVADVDSLLRAGADKVAVNTAAIAC  120
			  	121  PDLLADMARQFGSQCIVLSVDARTVPVGSAPTPSGWEVTTHGGRRGTGMDAVQWAARGAD  180
			  	181  LGVGEILLNSMDADGTKAGFDLALLRAVRAAVTVPVIASGGAGAVEHFAPAVAAGADAVL  240
			  	241  AASVFHFRELTIGQVKAALAAEGITVR

Known structures in the PDB
No Known structures
1 27 53 79 105 131 157 183 209 235 261 Range: 16 to 251  |  Coverage: 88% His_biosynth Range: 13 to 267  |  Coverage: 95% 1 Range: 1 to 267  |  Coverage: 99% 1
Number of amino acids : 267
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
His_biosynthPF0097716-251
Mtb Structural Proteome models
Model Number1
Model nameRv1605
Template1KA9    FPDBCREDO
Template coverage3_250
Template Identity(%)59.7
Model coverage(%)95.1
Normalized DOPE score-1.134

Structure Models from Chopin
Model Number1
Profilec.1.2.1
Click for model details
zscore53.52
Residue begin1
Residue end267
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1605Gene nameConfidence Score
Rv2121chisG0.999
Rv2121chisG0.999
Rv1606hisI0.999
Rv1599hisD0.999
Rv1600hisC10.999
Rv1601hisB0.999
Rv1602hisH0.999
Rv1603hisA0.998
Rv1609trpE0.99
Rv1609trpE0.99
Rv1611trpC0.976
Rv3772hisC20.971
Rv0957purH0.966
Rv0957purH0.966
Rv2192ctrpD0.965
Rv2192ctrpD0.965
Rv0500proC0.962
Rv0500proC0.962
Rv1612trpB0.955
Rv0809purM0.933
Rv0809purM0.933
Rv1604impA0.926
Rv0777purB0.925
Rv0777purB0.925
Rv2987cleuD0.925
Rv0382cpyrE0.924
Rv2988cleuC0.923
Rv0013trpG0.922
Rv0772purD0.92
Rv0772purD0.92
Rv0772purD0.92
Rv3710leuA0.906
Rv3710leuA0.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
imidazole glycerol phosphatePubChem0.976238.135
PRFARPubChem0.97577.331
aminoimidazole carboxamide ribonucleotidePubChem0.954338.211
5-aminoimidazole-4-carboxamide ribosidePubChem0.954338.211
Chebi:17805PubChem0.9238.135
phosphatePubChem0.86696.9872
hydron diphosphatePubChem0.772391.981
indole-3-glycerol phosphatePubChem0.76287.206
sulfatePubChem0.74396.0626
hydron sulfatePubChem0.743196.157
IGPSPubChem0.736287.206
glycerolPubChem0.71892.0938