Rv0777

Tuberculist information
Gene namepurB
Protein functionProbable adenylosuccinate lyase PurB (adenylosuccinase) (ASL) (ASASE)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)870.008
Molecular mass(da)51008.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 472
	  		  	1    VSIPNVLATRYASAEMVAIWSPEAKVVSERRLWLAVLRAQAELGVAVADSVLADYERVVD   60
			  	61   DVDLASISARERVLRHDVKARIEEFNALAGHEHVHKGMTSRDLTENVEQLQIRRSLEVIF  120
			  	121  AHGVAAVARLAERAVSYRDLIMAGRSHNVAAQATTLGKRFASAAQEMMIALRRLRELIDR  180
			  	181  YPLRGIKGPMGTGQDMLDLLGGDRAALADLERRVADFLGFATVFNSVGQVYPRSLDHDVV  240
			  	241  SALVQLGAGPSSLAHTIRLMAGHELATEGFAPGQVGSSAMPHKMNTRSCERVNGLQVVLR  300
			  	301  GYASMVAELAGAQWNEGDVFCSVVRRVALPDSFFAVDGQIETFLTVLDEFGAYPAVIGRE  360
			  	361  LDRYLPFLATTKVLMAAVRAGMGRESAHRLISEHAVATALAMREHGAEPDLLDRLAADPR  420
			  	421  LTLGRDALEAALADKKAFAGAAGDQVDDVVAMVDALVSRYPDAAKYTPGAIL

Known structures in the PDB
No Known structures
1 48 95 142 189 236 283 330 377 424 471 Range: 12 to 301  |  Coverage: 61% Lyase_1 Range: 365 to 450  |  Coverage: 18% ADSL_C Range: 5 to 462  |  Coverage: 96% 1 Range: 1 to 472  |  Coverage: 99% 1 Range: 94 to 440  |  Coverage: 73% 2
Number of amino acids : 472
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Lyase_1PF0020612-301
ADSL_CPF10397365-450
Mtb Structural Proteome models
Model Number1
Model nameRv0777
Template1YIS    APDBCREDO
Template coverage9_468
Template Identity(%)27.1
Model coverage(%)96.6
Normalized DOPE score0.162

Structure Models from Chopin
Model Number1
Profilea.127.1.1
Click for model details
zscore41.64
Residue begin1
Residue end472
Model Number2
Profile1.20.200.10
Click for model details
zscore21.35
Residue begin94
Residue end440
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0777Gene nameConfidence Score
Rv0780purC0.999
Rv0357cpurA0.999
Rv0957purH0.998
Rv0957purH0.998
Rv0808purF0.995
Rv0808purF0.995
Rv2584capt0.994
Rv0772purD0.992
Rv0772purD0.992
Rv0772purD0.992
Rv0733adk0.982
Rv0956purN0.975
Rv0809purM0.974
Rv0809purM0.974
Rv3396cguaA0.972
Rv3396cguaA0.972
Rv3396cguaA0.972
Rv1659argH0.957
Rv1659argH0.957
Rv3275cpurE0.957
Rv3624chpt0.955
Rv3276cpurK0.946
Rv1602hisH0.942
Rv0788purQ0.94
Rv0803purL0.93
Rv0803purL0.93
Rv1605hisF0.925
Rv3411cguaB20.916
Rv3411cguaB20.916
Rv3339cicd10.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine monophosphatePubChem0.99347.221
adenylosuccinatePubChem0.987463.293
fumaratePubChem0.983116.072
inosine monophosphatePubChem0.976348.206
SAICARPubChem0.967454.283
aspartatePubChem0.946133.103
aminoimidazole carboxamide ribonucleotidePubChem0.941338.211
5-aminoimidazole-4-carboxamide ribosidePubChem0.939338.211
adenosine triphosphatePubChem0.903507.181
phosphatePubChem0.90396.9872
FAIPubChem0.9366.221
5-formamidoimidazole-4-carboxamide ribotidePubChem0.9366.221
CHEBI:18319PubChem0.9454.283
tetrahydrofolatePubChem0.9445.429
NSC292227PubChem0.9338.211
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
5-amino-4-imidazolecarboxylic acid ribonucleotidePubChem0.9339.196
guanosine diphosphatePubChem0.9443.201
CHEBI:15919PubChem0.9463.293
adenosine diphosphatePubChem0.9427.201
guanosine triphosphatePubChem0.9523.18
H4FPubChem0.9445.429
potassium aspartatePubChem0.9133.103
10-formyltetrahydropteroylglutamic acidPubChem0.9473.439
5'-P-ribosyl-4-(N-succinocarboxamide)-5-aminoimidazolePubChem0.9454.283
10-formyltetrahydrofolatePubChem0.9473.439
chloridePubChem0.75435.453
adeninePubChem0.738135.127
hydron sulfatePubChem0.729196.157
sulfatePubChem0.72996.0626
glycerolPubChem0.70292.0938