Rv3339c

Tuberculist information
Gene nameicd1
Protein functionProbable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3724.61
Molecular mass(da)45513.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 409
	  		  	1    MSNAPKIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDYYDLGIEHRDATDDQVT   60
			  	61   IDAAYAIKKHGVGVKCATITPDEARVEEFNLKKMWLSPNGTIRNILGGTIFREPIVISNV  120
			  	121  PRLVPGWTKPIVIGRHAFGDQYRATNFKVDQPGTVTLTFTPADGSAPIVHEMVSIPEDGG  180
			  	181  VVLGMYNFKESIRDFARASFSYGLNAKWPVYLSTKNTILKAYDGMFKDEFERVYEEEFKA  240
			  	241  QFEAAGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMT  300
			  	301  ADGKTVEAEAAHGTVTRHYRQYQAGKPTSTNPIASIFAWTRGLQHRGKLDGTPEVIDFAH  360
			  	361  KLESVVIATVESGKMTKDLAILIGPEQDWLNSEEFLDAIADNLEKELAN

Known structures in the PDB
PDB ID4HCX
Total residue count818
Number of chains2
MethodX-RAY
Resolution2.18
1 41 81 121 161 201 241 281 321 361 401 Range: 8 to 399  |  Coverage: 95% Iso_dh Range: 5 to 408  |  Coverage: 98% 1 Range: 1 to 409  |  Coverage: 99% 1
Number of amino acids : 409
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Iso_dhPF001808-399
Mtb Structural Proteome models
Model Number1
Model nameRv3339c
Template1LWD    APDBCREDO
Template coverage3_411
Template Identity(%)65.8
Model coverage(%)98.5
Normalized DOPE score-1.1

Structure Models from Chopin
Model Number1
Profile3.40.718.10
Click for model details
zscore53.09
Residue begin1
Residue end409
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3339cGene nameConfidence Score
Rv0066cicd20.99
Rv1475cacn0.982
Rv1475cacn0.982
Rv1240mdh0.941
Rv1240mdh0.941
Rv2780ald0.929
Rv2780ald0.929
Rv0777purB0.909
Rv0777purB0.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
isocitratePubChem0.994192.124
NADPPubChem0.993744.413
alpha-ketoglutaratePubChem0.989146.098
D-isocitratePubChem0.982192.124
NADP(H)PubChem0.966745.421
NAD+PubChem0.93663.425
reduced nicotinamide adenine dinucleotidePubChem0.924665.441
cis-aconitatePubChem0.923174.108
succinyl-CoAPubChem0.921867.607
carbon dioxidePubChem0.91444.0095
dihydronicotinamide formycin dinucleotidePubChem0.911665.441
hydroxyl radicalsPubChem0.90717.0073
H(+)PubChem0.9042.01588
coenzyme APubChem0.904767.534
deuteriumPubChem0.9042.01588
suc-coaPubChem0.9867.607
Co-APubChem0.9767.534
glycerolPubChem0.80992.0938
magnesiumPubChem0.79524.305
citratePubChem0.76192.124
sulfatePubChem0.75496.0626
Na(+)PubChem0.75222.9898
hydron sulfatePubChem0.749196.157
diethylene glycolPubChem0.708106.12