Rv3411c

Tuberculist information
Gene nameguaB2
Protein functionProbable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3829.93
Molecular mass(da)54867
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 529
	  		  	1    MSRGMSGLEDSSDLVVSPYVRMGGLTTDPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVV   60
			  	61   PATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVE  120
			  	121  MVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVVDDDGALVGIITNRDMRFEVD  180
			  	181  QSKQVAEVMTKAPLITAQEGVSASAALGLLRRNKIEKLPVVDGRGRLTGLITVKDFVKTE  240
			  	241  QHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLK  300
			  	301  SEVGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEA  360
			  	361  VAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQYKS  420
			  	421  YRGMGSLGAMRGRGGATSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLTGG  480
			  	481  LRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYAR

Known structures in the PDB
No Known structures
1 53 105 157 209 261 313 365 417 469 521 Range: 43 to 515  |  Coverage: 89% IMPDH Range: 125 to 180  |  Coverage: 10% CBS Range: 185 to 238  |  Coverage: 10% CBS Range: 39 to 527  |  Coverage: 92% 1 Range: 38 to 508  |  Coverage: 88% 1 Range: 179 to 415  |  Coverage: 44% 2
Number of amino acids : 529
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
IMPDHPF0047843-515
CBSPF00571125-180
CBSPF00571185-238
Mtb Structural Proteome models
Model Number1
Model nameRv3411c
Template1ZFJ    APDBCREDO
Template coverage7_491
Template Identity(%)52.9
Model coverage(%)92.2
Normalized DOPE score0.154

Structure Models from Chopin
Model Number1
Profilec.1.5.1 - 3.20.20.70
Click for model details
zscore52.24
Residue begin38
Residue end508
Model Number2
Profilec.1.2.5 - 3.20.20.70
Click for model details
zscore10.74
Residue begin179
Residue end415
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3411cGene nameConfidence Score
Rv3396cguaA0.999
Rv3396cguaA0.999
Rv3396cguaA0.999
Rv0957purH0.996
Rv0957purH0.996
Rv0357cpurA0.992
Rv3410cguaB30.99
Rv3624chpt0.971
Rv1699pyrG0.944
Rv1699pyrG0.944
Rv3356cfolD0.942
Rv3356cfolD0.942
Rv0808purF0.933
Rv0808purF0.933
Rv1010ksgA0.924
Rv0809purM0.923
Rv0809purM0.923
Rv0777purB0.916
Rv0777purB0.916
Rv2783cgpsI0.903
Rv2783cgpsI0.903
Rv2783cgpsI0.903
Rv2783cgpsI0.903
Rv2783cgpsI0.903
Rv0956purN0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
inosine monophosphatePubChem0.994348.206
guanylatePubChem0.986363.221
xanthosine monophosphatePubChem0.986364.205
xanthosine 5'-phosphatePubChem0.981364.205
NAD+PubChem0.963663.425
mycophenolic acidPubChem0.937320.337
5-formamidoimidazole-4-carboxamide ribotidePubChem0.931366.221
H(+)PubChem0.9262.01588
deuteriumPubChem0.9212.01588
adenosine monophosphatePubChem0.911347.221
pyrophosphatePubChem0.903177.975
adenosine triphosphatePubChem0.901507.181
polyglutaminePubChem0.901146.145
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
glutamatePubChem0.9147.129
xanthosine-5'-phosphatePubChem0.9364.205
protiumPubChem0.92.01576
ammoniaPubChem0.917.0305
hydroxyl radicalsPubChem0.917.0073
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
FAIPubChem0.9366.221
glutaminPubChem0.9146.145
guaninePubChem0.845151.126
guanosinePubChem0.814283.241
tiazofurinPubChem0.79260.267
glutathionylspermidine disulfidePubChem0.786867.092
diphenyl ureaPubChem0.771212.247
6-chloropurine riboside 5'-monophosphatePubChem0.758366.652
guanosine triphosphatePubChem0.753523.18
beta-methylene-TADPubChem0.752667.48
guanosine diphosphatePubChem0.735443.201
thiazole-4-carboxamide adenine dinucleotidePubChem0.735669.453
hypoxanthinePubChem0.717136.111
4-carbamoylimidazolium 5-olatePubChem0.715127.101
selenazole-4-carboxamide adenine dinucleotidePubChem0.709716.348
mizoribine monophosphatePubChem0.708339.196
inosinePubChem0.704268.226