SInCRe - Rv3410c

Tuberculist information

Gene name	guaB3
Protein function	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	3828.78
Molecular mass(da)	38990.6
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 375

	  		  	1    MVEIGMGRTARRTYELSEISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPE   60
			  	61   FAIELGRLGGLGVLNGEGLIGRHLDVEAKIAQLLEAAAADPEPSTAIRLLQELHAAPLNP  120
			  	121  DLLGAAVARIREAGVTTAVRVSPQNAQWLTPVLVAAGIDLLVIQGTIVSAERVASDGEPL  180
			  	181  NLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTQGVTTTDEVLGISVPMAT  240
			  	241  AIADAAAARRDYLDETGGRYVHVLADGDIHTSGELAKAIACGADAVVLGTPLAESAEALG  300
			  	301  EGWFWPAAAAHPSLPRGALLQIAVGERPPLARVLGGPSDDPFGGLNLVGGLRRSMAKAGY  360
			  	361  CDLKEFQKVGLTVGG

Known structures in the PDB

No Known structures

Number of amino acids : 375

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
IMPDH	PF00478	12-307

Mtb Structural Proteome models

Model Number	1
Model name	Rv3410c
Template	1VRD APDB CREDO
Template coverage	2_455
Template Identity(%)	29.2
Model coverage(%)	96.5
Normalized DOPE score	0.247

Structure Models from Chopin

Model Number	1
Profile	c.1.5.1 - 3.20.20.70 Click for model details
zscore	38.05
Residue begin	7
Residue end	375

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3410c	Gene name	Confidence Score
Rv3396c	guaA	0.992
Rv3396c	guaA	0.992
Rv3396c	guaA	0.992
Rv3411c	guaB2	0.99
Rv3411c	guaB2	0.99
Rv1843c	guaB1	0.968
Rv1843c	guaB1	0.968
Rv0957	purH	0.939
Rv0957	purH	0.939
Rv0357c	purA	0.902

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
inosine monophosphatePubChem	0.948	348.206
5-formamidoimidazole-4-carboxamide ribotidePubChem	0.9	366.221
xanthosine-5'-phosphatePubChem	0.9	364.205
polyglutaminePubChem	0.9	146.145
xanthosine monophosphatePubChem	0.9	364.205
deuteriumPubChem	0.9	2.01588
protiumPubChem	0.9	2.01576
glutaminPubChem	0.9	146.145
NAD+PubChem	0.9	663.425
adenosine monophosphatePubChem	0.9	347.221
hydroxyl radicalsPubChem	0.9	17.0073
dihydronicotinamide formycin dinucleotidePubChem	0.9	665.441
glutamatePubChem	0.9	147.129
pyrophosphatePubChem	0.9	177.975
xanthosine 5'-phosphatePubChem	0.9	364.205
guanylatePubChem	0.9	363.221
FAIPubChem	0.9	366.221
ammoniaPubChem	0.9	17.0305
H(+)PubChem	0.9	2.01588
reduced nicotinamide adenine dinucleotidePubChem	0.9	665.441
adenosine triphosphatePubChem	0.9	507.181
SeMetPubChem	0.704	196.106
selenomethioninePubChem	0.704	196.106