Rv0788

Tuberculist information
Gene namepurQ
Protein functionProbable phosphoribosylformylglycinamidine synthase I PURG (FGAM synthase I)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)882.76
Molecular mass(da)23600.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 224
	  		  	1    VTARIGVVTFPGTLDDVDAARAARQVGAEVVSLWHADADLKGVDAVVVPGGFSYGDYLRA   60
			  	61   GAIARFAPVMDEVVAAADRGMPVLGICNGFQVLCEAGLLPGALTRNVGLHFICRDVWLRV  120
			  	121  ASTSTAWTSRFEPDADLLVPLKSGEGRYVAPEKVLDELEGEGRVVFRYHDNVNGSLRDIA  180
			  	181  GICSANGRVVGLMPHPEHAIEALTGPSDDGLGLFYSALDAVLTG

Known structures in the PDB
No Known structures
1 23 45 67 89 111 133 155 177 199 221 Range: 2 to 218  |  Coverage: 96% GATase_5 Range: 2 to 219  |  Coverage: 96% 1 Range: 1 to 224  |  Coverage: 99% 1
Number of amino acids : 224
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GATase_5PF135072-218
Mtb Structural Proteome models
Model Number1
Model nameRv0788
Template1T3T    APDBCREDO
Template coverage1039_1292
Template Identity(%)30.3
Model coverage(%)96.9
Normalized DOPE score-0.135

Structure Models from Chopin
Model Number1
Profilec.23.16.1 - 3.40.50.880
Click for model details
zscore17.44
Residue begin1
Residue end224
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0788Gene nameConfidence Score
Rv0787ARv0787A0.999
Rv0956purN0.999
Rv0803purL0.999
Rv0803purL0.999
Rv0772purD0.998
Rv0772purD0.998
Rv0772purD0.998
Rv0809purM0.997
Rv0809purM0.997
Rv3275cpurE0.993
Rv0808purF0.991
Rv0808purF0.991
Rv3276cpurK0.984
Rv0957purH0.982
Rv0957purH0.982
Rv0389purT0.976
Rv0777purB0.94
Rv0777purB0.94
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
5'-phosphoribosylformylglycinamidinePubChem0.971313.202
FGARPubChem0.97314.186
FGAMPubChem0.97312.194
formylglycinamide ribonucleotidePubChem0.97314.186
adenosine diphosphatePubChem0.969427.201
glycinamide ribonucleotidePubChem0.963286.176
glutamatePubChem0.938147.129
5-aminoimidazole ribonucleotidePubChem0.9295.186
hydroxyl radicalsPubChem0.917.0073
H(+)PubChem0.92.01588
protiumPubChem0.92.01576
formatePubChem0.945.0174
phosphoribosylaminoimidazolePubChem0.9294.178
polyglutaminePubChem0.9146.145
glutaminPubChem0.9146.145
phosphatePubChem0.996.9872
5'-phosphoribosyl-N-formylglycinamidePubChem0.9314.186
adenosine triphosphatePubChem0.9507.181
deuteriumPubChem0.92.01588
NSC333308PubChem0.9286.176
2-amino-4-(2-amino-2-carboxy-ethyl)sulfanylcarbonyl-butanoic AcidPubChem0.702250.272
Na(+)PubChem0.70222.9898