Rv0780

Tuberculist information
Gene namepurC
Protein functionPhosphoribosylaminoimidazole- succinocarboxamide synthase PurC (SAICAR synthetase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)873.343
Molecular mass(da)32930.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 297
	  		  	1    MRPALSDYQHVASGKVREIYRVDDEHLLLVASDRISAYDYVLDSTIPDKGRVLTAMSAFF   60
			  	61   FGLVDAPNHLAGPPDDPRIPDEVLGRALVVRRLEMLPVECVARGYLTGSGLLDYQATGKV  120
			  	121  CGIALPPGLVEASRFATPLFTPATKAALGDHDENISFDRVVEMVGALRANQLRDRTLQTY  180
			  	181  VQAADHALTRGIIIADTKFEFGIDRHGNLLLADEIFTPDSSRYWPADDYRAGVVQTSFDK  240
			  	241  QFVRSWLTGSESGWDRGSDRPPPPLPEHIVEATRARYINAYERISELKFDDWIGPGA

Known structures in the PDB
No Known structures
1 30 59 88 117 146 175 204 233 262 291 Range: 7 to 262  |  Coverage: 85% SAICAR_synt Range: 11 to 289  |  Coverage: 93% 1 Range: 1 to 290  |  Coverage: 97% 1
Number of amino acids : 297
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
SAICAR_syntPF012597-262
Mtb Structural Proteome models
Model Number1
Model nameRv0780
Template2CNQ    APDBCREDO
Template coverage15_304
Template Identity(%)44.8
Model coverage(%)93.6
Normalized DOPE score-0.822

Structure Models from Chopin
Model Number1
Profiled.143.1.1
Click for model details
zscore46.54
Residue begin1
Residue end290
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0780Gene nameConfidence Score
Rv0777purB0.999
Rv0777purB0.999
Rv3275cpurE0.997
Rv0772purD0.994
Rv0772purD0.994
Rv0772purD0.994
Rv0808purF0.979
Rv0808purF0.979
Rv0809purM0.975
Rv0809purM0.975
Rv0957purH0.974
Rv0957purH0.974
Rv0956purN0.969
Rv3276cpurK0.961
Rv0787ARv0787A0.948
Rv0357cpurA0.939
Rv0803purL0.934
Rv0803purL0.934
Rv3396cguaA0.926
Rv3396cguaA0.926
Rv3396cguaA0.926
Rv0782ptrBb0.924
Rv0782ptrBb0.924
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
SAICARPubChem0.986454.283
aminoimidazole carboxamide ribonucleotidePubChem0.982338.211
5-aminoimidazole-4-carboxamide ribosidePubChem0.981338.211
adenosine diphosphatePubChem0.976427.201
aspartatePubChem0.974133.103
adenosine triphosphatePubChem0.974507.181
5-amino-4-imidazolecarboxylic acid ribonucleotidePubChem0.94339.196
phosphatePubChem0.91696.9872
N5-CAIRPubChem0.902339.196
deuteriumPubChem0.92.01588
potassium aspartatePubChem0.9133.103
5'-P-ribosyl-4-(N-succinocarboxamide)-5-aminoimidazolePubChem0.9454.283
protiumPubChem0.92.01576
fumaratePubChem0.9116.072
NSC292227PubChem0.9338.211
H(+)PubChem0.92.01588
sulfatePubChem0.76496.0626
hydron sulfatePubChem0.764196.157
adeninePubChem0.758135.127
magnesiumPubChem0.73724.305
adenosine monophosphatePubChem0.728347.221
succinatePubChem0.704118.088
SSSPubChem0.704454.283
hydron; succinatePubChem0.704119.096
acetaldehydePubChem0.70444.0526