Rv0782

Tuberculist information
Gene nameptrBb
Protein functionProbable protease II PtrBb [second part] (oligopeptidase B)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)874.732
Molecular mass(da)60864.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 552
	  		  	1    VTNDIPCGSRIYAPENSTRTRSPGSERESPGQLTTTVYYTTVDAAWRPDTVWRYRLGSGE   60
			  	61   SSERVYHEADDRFWLAVGRTRSNAYLLIAAGSSITSEVRYAHAADPTAQFSVVLPRRDGV  120
			  	121  EYSVEHAVIAGQDRFLILHNDGAVNFTLVEAPVEDPARQRTLIAHRDDVRLDAVDALAGH  180
			  	181  LVVSYRREALPRVQLWPIGPDGNYGEPEEISFDSELMSAGLGPNPNWDSPKLRVGAGSFV  240
			  	241  TPVRIYDIDLVTGERTLLKEQPVLGGYRREDYVERRDWAYGDDGTRIPVSIVHRADIEFP  300
			  	301  APALIYGYGAYEICEDPRFSIARLSLLDRGMVFVVAHVRGGGEMGRLWYENGKLLDKKNT  360
			  	361  FTDFIAVARHLVDTGLTSQQQLVALGGSAGGLLMGAVANMAPDLFAGILAQVPFVDPLTT  420
			  	421  ILDPSLPLTVTEWDEWGNPLNDSDVYAYVKSYSPYENVTAQKYPAILAMTSLNDTRVYYV  480
			  	481  EPAKWVAALRHAKTDGNSVLLKTQMHAGHGGISGRYERWKETAFQYGWLLATADSDRYGG  540
			  	541  GQGNDLDGAAPA

Known structures in the PDB
No Known structures
1 56 111 166 221 276 331 386 441 496 551 Range: 32 to 261  |  Coverage: 41% Peptidase_S9_N Range: 317 to 536  |  Coverage: 39% Peptidase_S9 Range: 4 to 534  |  Coverage: 96% 1 Range: 1 to 539  |  Coverage: 97% 1 Range: 268 to 539  |  Coverage: 49% 2 Range: 32 to 261  |  Coverage: 41% 3
Number of amino acids : 552
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Peptidase_S9_NPF0289732-261
Peptidase_S9PF00326317-536
Mtb Structural Proteome models
Model Number1
Model nameRv0782
Template2BKL    APDBCREDO
Template coverage142_676
Template Identity(%)27.1
Model coverage(%)96.0
Normalized DOPE score-0.121

Structure Models from Chopin
Model Number1
Profileb.69.7.1, c.69.1.4 - 2.130.10.120, 3.40.50.1820
Click for model details
zscore61.7
Residue begin1
Residue end539
Model Number2
Profilec.69.1.4
Click for model details
zscore44.35
Residue begin268
Residue end539
Model Number3
Profile2.130.10.120
Click for model details
zscore21.31
Residue begin32
Residue end261
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0782Gene nameConfidence Score
Rv0781ptrBa0.996
Rv0780purC0.924
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions