Rv0781

Tuberculist information
Gene nameptrBa
Protein functionProbable protease II PtrBa [first part] (oligopeptidase B)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)874.233
Molecular mass(da)26916
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 236
	  		  	1    MMHRTALPSPPVAKRVQTRREHHGDVFVDPYEWLRDKDSPEVIAYLEAENDYTERTTAHL   60
			  	61   EPLRQKIFHEIKARTKETDLSVPTRRGNWWYYARTFEGKQYGVHCRCPVTDPDDWNPPEF  120
			  	121  DERTEIPGEQLLLDENVEADGHDFFALGAASVSLDDNLLAYSVDVVGDERYTLRFKDLRT  180
			  	181  GEQYPDEIAGIGAGVTWAADNHCLLHHRGRGLASGHSVAIPTRVRRIVGAGLPRSR

Known structures in the PDB
No Known structures
1 24 47 70 93 116 139 162 185 208 231 Range: 10 to 227  |  Coverage: 91% Peptidase_S9_N Range: 8 to 236  |  Coverage: 96% 1 Range: 5 to 236  |  Coverage: 97% 1
Number of amino acids : 236
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Peptidase_S9_NPF0289710-227
Mtb Structural Proteome models
Model Number1
Model nameRv0781
Template1YR2    APDBCREDO
Template coverage38_258
Template Identity(%)25.4
Model coverage(%)96.6
Normalized DOPE score0.753

Structure Models from Chopin
Model Number1
Profileb.69.7.1
Click for model details
zscore34.18
Residue begin5
Residue end236
Binding pockets
STRING
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Protein interacting with Rv0781Gene nameConfidence Score
Rv0782ptrBb0.996
Rv0782ptrBb0.996
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions