Rv1604

Tuberculist information
Gene nameimpA
Protein functionProbable inositol-monophosphatase ImpA (imp)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1804.04
Molecular mass(da)27978.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 270
	  		  	1    MHLDSLVAPLVEQASAILDAATALFLVGHRADSAVRKKGNDFATEVDLAIERQVVAALVA   60
			  	61   ATGIEVHGEEFGGPAVDSRWVWVLDPIDGTINYAAGSPLAAILLGLLHDGVPVAGLTWMP  120
			  	121  FTDPRYTAVAGGPLIKNGVPQPPLADAELANVLVGVGTFSADSRGQFPGRYRLAVLEKLS  180
			  	181  RVSSRLRMHGSTGIDLVFVADGILGGAISFGGHVWDHAAGVALVRAAGGVVTDLAGQPWT  240
			  	241  PASRSALAGPPRVHAQILEILGSIGEPEDY

Known structures in the PDB
No Known structures
1 28 55 82 109 136 163 190 217 244 271 Range: 2 to 266  |  Coverage: 97% Inositol_P Range: 10 to 262  |  Coverage: 93% 1 Range: 1 to 270  |  Coverage: 99% 1 Range: 141 to 269  |  Coverage: 47% 2
Number of amino acids : 270
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Inositol_PPF004592-266
Mtb Structural Proteome models
Model Number1
Model nameRv1604
Template2BJI    APDBCREDO
Template coverage1015_1267
Template Identity(%)24.5
Model coverage(%)93.0
Normalized DOPE score-0.194

Structure Models from Chopin
Model Number1
Profilee.7.1.1
Click for model details
zscore30.29
Residue begin1
Residue end270
Model Number2
Profile3.40.190.80
Click for model details
zscore14.48
Residue begin141
Residue end269
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1604Gene nameConfidence Score
Rv0046cino10.963
Rv0046cino10.963
Rv1605hisF0.926
Rv2131ccysQ0.911
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
inositol 1-phosphatePubChem0.983260.136
myo-inositolPubChem0.969180.156
phosphatePubChem0.93996.9872
L-myo-inositol 1-phosphatePubChem0.924260.136
hydroxyl radicalsPubChem0.917.0073