Tuberculist information
Gene nameino1
Protein functionmyo-inositol-1-phosphate synthase Ino1 (inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (glucose 6-phosphate cyclase) (glucocycloaldolase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)50.021
Molecular mass(da)40093.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 367
	  		  	1    MSEHQSLPAPEASTEVRVAIVGVGNCASSLVQGVEYYYNADDTSTVPGLMHVRFGPYHVR   60
			  	61   DVKFVAAFDVDAKKVGFDLSDAIFASENNTIKIADVAPTNVIVQRGPTLDGIGKYYADTI  120
			  	121  ELSDAEPVDVVQALKEAKVDVLVSYLPVGSEEADKFYAQCAIDAGVAFVNALPVFIASDP  180
			  	181  VWAKKFTDARVPIVGDDIKSQVGATITHRVLAKLFEDRGVQLDRTMQLNVGGNMDFLNML  240
			  	241  ERERLESKKISKTQAVTSNLKREFKTKDVHIGPSDHVGWLDDRKWAYVRLEGRAFGDVPL  300
			  	301  NLEYKLEVWDSPNSAGVIIDAVRAAKIAKDRGIGGPVIPASAYLMKSPPEQLPDDIARAQ  360
			  	361  LEEFIIG
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NAD_binding_5PF0799416-366
Inos-1-P_synthPF01658203-311
Mtb Structural Proteome models
Model Number1
Model nameRv0046c_1gr0_A
Template1GR0    APDBCREDO
Template coverage14_367
Template Identity(%)100.0
Model coverage(%)96.2
Normalized DOPE score-1.412

Model Number2
Model nameRv0046c
Template1GR0    APDBCREDO
Template coverage14_367
Template Identity(%)100.0
Model coverage(%)96.2
Normalized DOPE score-0.866

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0046cGene nameConfidence Score
Rv1604impA0.963
Rv3068cpgmA0.962
Rv3068cpgmA0.962
Rv3068cpgmA0.962
Rv3068cpgmA0.962
Rv2701csuhB0.961
Rv0486mshA0.913
Rv0486mshA0.913
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.991663.425
dimethylarsinic acidPubChem0.979137.997
zincPubChem0.965.409
glucose-6-phosphatePubChem0.9260.136
L-myo-inositol 1-phosphatePubChem0.9260.136
inositol 1-phosphatePubChem0.9260.136
DB03363PubChem0.8663.425