Rv2701c

Tuberculist information
Gene namesuhB
Protein functionInositol-1-monophosphatase SuhB
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3015.86
Molecular mass(da)29995
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 290
	  		  	1    VTRPDNEPARLRSVAENLAAEAAAFVRGRRAEVFGISRAGDGDGAVRAKSSPTDPVTVVD   60
			  	61   TDTERLLRDRLAQLRPGDPILGEEGGGPADVTATPSDRVTWVLDPIDGTVNFVYGIPAYA  120
			  	121  VSIGAQVGGITVAGAVADVAARTVYSAATGLGAHLTDERGRHVLRCTGVDELSMALLGTG  180
			  	181  FGYSVRCREKQAELLAHVVPLVRDVRRIGSAALDLCMVAAGRLDAYYEHGVQVWDCAAGA  240
			  	241  LIAAEAGARVLLSTPRAGGAGLVVVAAAPGIADELLAALQRFNGLEPIPD

Known structures in the PDB
PDB ID2Q74
Total residue count897
Number of chains3
MethodX-RAY
Resolution2.6
1 30 59 88 117 146 175 204 233 262 291 Range: 7 to 284  |  Coverage: 95% Inositol_P Range: 5 to 286  |  Coverage: 96% 1 Range: 9 to 280  |  Coverage: 93% 2 Range: 1 to 290  |  Coverage: 99% 1 Range: 164 to 287  |  Coverage: 42% 2 Range: 1 to 207  |  Coverage: 71% 3
Number of amino acids : 290
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Inositol_PPF004597-284
Mtb Structural Proteome models
Model Number1
Model nameRv2701c_2q74_A
Template2Q74    APDBCREDO
Template coverage5_286
Template Identity(%)100.0
Model coverage(%)96.9
Normalized DOPE score-1.085

Model Number2
Model nameRv2701c
Template2BJI    APDBCREDO
Template coverage1006_1267
Template Identity(%)32.1
Model coverage(%)93.4
Normalized DOPE score0.05

Structure Models from Chopin
Model Number1
Profilee.7.1.1
Click for model details
zscore27.83
Residue begin1
Residue end290
Model Number2
Profile3.40.190.80
Click for model details
zscore13.91
Residue begin164
Residue end287
Model Number3
Profile3.30.540.10
Click for model details
zscore12.34
Residue begin1
Residue end207
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2701cGene nameConfidence Score
Rv0046cino10.961
Rv0046cino10.961
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
inositol 1-phosphatePubChem0.987260.136
L-myo-inositol 1-phosphatePubChem0.945260.136
magnesiumPubChem0.83224.305
lithiumPubChem0.7936.941
myo-inositolPubChem0.727180.156
sorbitol 6-phosphatePubChem0.708262.152
2'-AMPPubChem0.7347.221