Rv0486

Tuberculist information
Gene namemshA
Protein functionGlycosyltransferase MshA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)575.348
Molecular mass(da)50541.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 480
	  		  	1    MAGVRHDDGSGLIAQRRPVRGEGATRSRGPSGPSNRNVSAADDPRRVALLAVHTSPLAQP   60
			  	61   GTGDAGGMNVYMLQSALHLARRGIEVEIFTRATASADPPVVRVAPGVLVRNVVAGPFEGL  120
			  	121  DKYDLPTQLCAFAAGVLRAEAVHEPGYYDIVHSHYWLSGQVGWLARDRWAVPLVHTAHTL  180
			  	181  AAVKNAALADGDGPEPPLRTVGEQQVVDEADRLIVNTDDEARQVISLHGADPARIDVVHP  240
			  	241  GVDLDVFRPGDRRAARAALGLPVDERVVAFVGRIQPLKAPDIVLRAAAKLPGVRIIVAGG  300
			  	301  PSGSGLASPDGLVRLADELGISARVTFLPPQSHTDLATLFRAADLVAVPSYSESFGLVAV  360
			  	361  EAQACGTPVVAAAVGGLPVAVRDGITGTLVSGHEVGQWADAIDHLLRLCAGPRGRVMSRA  420
			  	421  AARHAATFSWENTTDALLASYRRAIGEYNAERQRRGGEVISDLVAVGKPRHWTPRRGVGA  480

Known structures in the PDB
No Known structures
1 49 97 145 193 241 289 337 385 433 481 Range: 66 to 241  |  Coverage: 36% Glyco_trans_4_4 Range: 251 to 424  |  Coverage: 36% Glycos_transf_1 Range: 45 to 447  |  Coverage: 83% 1 Range: 251 to 424  |  Coverage: 36% 1 Range: 9 to 447  |  Coverage: 91% 2
Number of amino acids : 480
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Glyco_trans_4_4PF1357966-241
Glycos_transf_1PF00534251-424
Mtb Structural Proteome models
Model Number1
Model nameRv0486
Template2BIS    APDBCREDO
Template coverage1_431
Template Identity(%)23.6
Model coverage(%)83.8
Normalized DOPE score-0.108

Structure Models from Chopin
Model Number1
Profilec.87.1.8
Click for model details
zscore32.3
Residue begin251
Residue end424
Model Number2
Profilec.87.1.8
Click for model details
zscore27.21
Residue begin9
Residue end447
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0486Gene nameConfidence Score
Rv0046cino10.913
Rv0046cino10.913
Rv3137Rv31370.91
Rv1170mshB0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions