Rv0505c

Tuberculist information
Gene nameserB1
Protein functionPossible phosphoserine phosphatase SerB1 (PSP) (O-phosphoserine phosphohydrolase) (pspase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)595.464
Molecular mass(da)39508
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 373
	  		  	1    MGLTCWPRTAAGRVHDESRCGLANFDTALGLQINPRQPRAPPRICRIGLITAAASATGQA   60
			  	61   PRLGVMMVSSHLGSPDQAGHVDLASPADPPPPDASASHSPVDMPAPVAAAGSDRQPPIDL  120
			  	121  TAAAFFDVDNTLVQGSSAVHFGRGLAARHYFTYRDVLGFLYAQAKFQLLGKENSNDVAAG  180
			  	181  RRKALAFIEGRSVAELVALGEEIYDEIIADKIWDGTRELTQMHLDAGQQVWLITATPYEL  240
			  	241  AATIARRLGLTGALGTVAESVDGIFTGRLVGEILHGTGKAHAVRSLAIREGLNLKRCTAY  300
			  	301  SDSYNDVPMLSLVGTAVAINPDARLRSLARERGWEIRDFRIARKAARIGVPSALALGAAG  360
			  	361  GALAALASRRQSR

Known structures in the PDB
No Known structures
1 38 75 112 149 186 223 260 297 334 371 Range: 124 to 311  |  Coverage: 50% HAD Range: 120 to 344  |  Coverage: 60% 1 Range: 124 to 311  |  Coverage: 50% 1 Range: 270 to 330  |  Coverage: 16% 2
Number of amino acids : 373
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HADPF12710124-311
Mtb Structural Proteome models
Model Number1
Model nameRv0505c
Template1L7M    APDBCREDO
Template coverage4_208
Template Identity(%)23.9
Model coverage(%)60.1
Normalized DOPE score-0.137

Structure Models from Chopin
Model Number1
Profilec.108.1.4
Click for model details
zscore16.7
Residue begin124
Residue end311
Model Number2
Profilec.108.1.4
Click for model details
zscore11.16
Residue begin270
Residue end330
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0505cGene nameConfidence Score
Rv0884cserC0.933
Rv1613trpA0.917
Rv1093glyA10.907
Rv0070cglyA20.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
phosphatePubChem0.996.9872
O-phosphoserinePubChem0.9185.072
hydroxyl radicalsPubChem0.917.0073
L-serinePubChem0.9105.093