Rv0069c

Tuberculist information
Gene namesdaA
Protein functionProbable L-serine dehydratase SdaA (L-serine deaminase) (SDH) (L-SD)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)76.237
Molecular mass(da)48576.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 461
	  		  	1    MTISVFDLFTIGIGPSSSHTVGPMRAANQFVVALRRRGHLDDLEAMRVDLFGSLAATGAG   60
			  	61   HGTMSAILLGLEGCQPETITTEHKERRLAEIAASGVTRIGGVIPVPLTERDIDLHPDIVL  120
			  	121  PTHPNGMTFTAAGPHGRVLATETYFSVGGGFIVTEQTSGNSGQHPCSVALPYVSAQELLD  180
			  	181  ICDRLDVSISEAALRNETCCRTENEVRAALLHLRDVMVECEQRSIAREGLLPGGLRVRRR  240
			  	241  AKVWYDRLNAEDPTRKPEFAEDWVNLVALAVNEENASGGRVVTAPTNGAAGIVPAVLHYA  300
			  	301  IHYTSAGAGDPDDVTVRFLLTAGAIGSLFKERASISGAEVGCQGEVGSAAAMAAAGLAEI  360
			  	361  LGGTPRQVENAAEIAMEHSLGLTCDPIAGLVQIPCIERNAISAGKAINAARMALRGDGIH  420
			  	421  RVTLDQVIDTMRATGADMHTKYKETSAGGLAINVAVNIVEC

Known structures in the PDB
No Known structures
1 47 93 139 185 231 277 323 369 415 461 Range: 4 to 160  |  Coverage: 33% SDH_beta Range: 183 to 453  |  Coverage: 58% SDH_alpha
Number of amino acids : 461
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
SDH_betaPF033154-160
SDH_alphaPF03313183-453
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
Structure models not available for this query
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0069cGene nameConfidence Score
Rv0070cglyA20.994
Rv3042cserB20.984
Rv3042cserB20.984
Rv1093glyA10.968
Rv1559ilvA0.949
Rv1559ilvA0.949
Rv1613trpA0.94
Rv1077cbs0.903
Rv1077cbs0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-serinePubChem0.977105.093
ammoniaPubChem0.91817.0305
deuteriumPubChem0.92.01588
pyruvic acidPubChem0.988.0621
H(+)PubChem0.92.01588
protiumPubChem0.92.01576
DL-serinePubChem0.9105.093
magnesiumPubChem0.75724.305
selenomethioninePubChem0.705196.106
SeMetPubChem0.705196.106