Tuberculist information
Gene nameserB2
Protein functionProbable phosphoserine phosphatase SerB2 (PSP) (O-phosphoserine phosphohydrolase) (pspase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3401.93
Molecular mass(da)43058.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 409
	  		  	1    MPAKVSVLITVTGMDQPGVTSALFEVLAQHGVELLNVEQVVIRGRLTLGVLVSCPLDVAD   60
			  	61   GTALRDDVAAAIHGVGLDVAIERSDDLPIIRQPSTHTIFVLGRPITAGAFSAVARGVAAL  120
			  	121  GVNIDFIRGISDYPVTGLELRVSVPPGCVGPLQIALTKVAAEEHVDVAVEDYGLAWRTKR  180
			  	181  LIVFDVDSTLVQGEVIEMLAARAGAQGQVAAITEAAMRGELDFAESLQRRVATLAGLPAT  240
			  	241  VIDDVAEQLELMPGARTTIRTLRRLGFRCGVVSGGFRRIIEPLARELMLDFVASNELEIV  300
			  	301  DGILTGRVVGPIVDRPGKAKALRDFASQYGVPMEQTVAVGDGANDIDMLGAAGLGIAFNA  360
			  	361  KPALREVADASLSHPYLDTVLFLLGVTRGEIEAADAGDCGVRRVEIPAD
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ACT_6PF137406-82
HADPF12710182-350
Mtb Structural Proteome models
Model Number1
Model nameRv3042c
Template1L7M    APDBCREDO
Template coverage3_211
Template Identity(%)41.1
Model coverage(%)50.9
Normalized DOPE score-1.539

Model Number2
Model nameRv3042c.1
Template2B8E    APDBCREDO
Template coverage415_663
Template Identity(%)20.7
Model coverage(%)69.2
Normalized DOPE score0.679

Structure Models from Chopin
Model Number1
Profilec.108.1.4
Click for model details
zscore41.27
Residue begin170
Residue end385
Model Number2
Profiled.58.18.7 - 3.30.70.260
Click for model details
zscore18.34
Residue begin6
Residue end82
Model Number3
Profiled.58.18.3
Click for model details
zscore6.48
Residue begin96
Residue end164
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3042cGene nameConfidence Score
Rv0884cserC0.994
Rv1093glyA10.993
Rv0070cglyA20.993
Rv2996cserA10.988
Rv2996cserA10.988
Rv2996cserA10.988
Rv0069csdaA0.984
Rv0069csdaA0.984
Rv1612trpB0.964
Rv1613trpA0.956
Rv1559ilvA0.943
Rv1559ilvA0.943
Rv2335cysE0.927
Rv2335cysE0.927
Rv1077cbs0.921
Rv1077cbs0.921
Rv0436cpssA0.92
Rv1601hisB0.914
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv3042c.162y6o_1N1_A_1892PDBCREDO0.6500.1240.6090.002
Rv3042c.143ndt_ROC_A_101PDBCREDO0.6000.1790.5870.003
Rv3042c.163spk_TPV_A_100PDBCREDO0.6010.1780.5810.003
Rv3042c.162fum_MIX_D_3539PDBCREDO0.6170.1590.5770.003
Rv3042c.143k4v_ROC_B_201PDBCREDO0.6000.1790.5750.003
Rv3042c.163oht_1N1_B_1000PDBCREDO0.6580.1170.5740.003
Rv3042c.163oez_STI_B_601PDBCREDO0.6320.1430.5730.003
Rv3042c.143tkg_ROC_B_801PDBCREDO0.6080.1700.5710.004
Rv3042c.143oxc_ROC_A_401PDBCREDO0.6300.1450.5670.004
Rv3042c.163hec_STI_A_1PDBCREDO0.6210.1540.5640.004
Rv3042c.143ndu_ROC_A_101PDBCREDO0.5990.1800.5640.004
Rv3042c.164asd_BAX_A_1500PDBCREDO0.7020.0800.5640.004
Rv3042c.162jfa_RAL_A_600PDBCREDO0.6200.1560.5620.004
Rv3042c.162xkw_P1B_B_1475PDBCREDO0.6640.1110.5580.004
Rv3042c.163bbt_FMM_D_91PDBCREDO0.5940.1860.5550.005
Rv3042c.161qkn_RAL_A_600PDBCREDO0.5710.2150.5530.005
Rv3042c.163v5w_8PR_A_701PDBCREDO0.5710.2150.5530.005
Rv3042c.161s9p_DES_A_459PDBCREDO0.6320.1430.5510.005
Rv3042c.161err_RAL_B_600PDBCREDO0.6240.1510.5490.005
Rv3042c.162jfa_RAL_B_600PDBCREDO0.6240.1510.5490.005
Rv3042c.163oct_1N1_A_663PDBCREDO0.6070.1700.5490.005
Rv3042c.161err_RAL_A_600PDBCREDO0.6210.1540.5470.005
Rv3042c.163oht_1N1_A_1000PDBCREDO0.6990.0820.5460.005
Rv3042c.141ya4_CTX_A_1PDBCREDO0.7620.0420.5450.005
Rv3042c.161zgy_BRL_A_503PDBCREDO0.5620.2280.5430.006
Rv3042c.161uwh_BAX_B_1723PDBCREDO0.6370.1380.5430.006
Rv3042c.163tne_RIT_A_401PDBCREDO0.5980.1820.5430.006
Rv3042c.161uwh_BAX_A_1723PDBCREDO0.6360.1390.5430.006
Rv3042c.162hyy_STI_B_600PDBCREDO0.6550.1190.5420.006
Rv3042c.143tl9_ROC_A_401PDBCREDO0.6290.1460.5420.006
Rv3042c.161bsx_T3_A_1PDBCREDO0.5590.2320.5410.006
Rv3042c.161bsx_T3_B_2PDBCREDO0.5590.2320.5410.006
Rv3042c.161jg2_ADN_A_500PDBCREDO0.5990.1800.5410.006
Rv3042c.163gws_T3_X_500PDBCREDO0.5570.2340.5390.006
Rv3042c.161s9p_DES_D_600PDBCREDO0.6120.1650.5340.006
Rv3042c.143bvb_017_B_401PDBCREDO0.7450.0510.5340.007
Rv3042c.163k54_1N1_A_1PDBCREDO0.6560.1190.5320.007
Rv3042c.163heg_BAX_A_1PDBCREDO0.6400.1350.5300.007
Rv3042c.161xzx_T3_X_500PDBCREDO0.5650.2230.5290.007
Rv3042c.163uvv_T3_A_501PDBCREDO0.5650.2230.5290.007
Rv3042c.162h79_T3_A_1PDBCREDO0.5290.2740.5290.007
Rv3042c.163jwq_VIA_D_901PDBCREDO0.5650.2240.5280.007
Rv3042c.162fum_MIX_A_539PDBCREDO0.6270.1490.5270.007
Rv3042c.143mws_017_B_201PDBCREDO0.5610.2280.5270.007
Rv3042c.142f80_017_B_301PDBCREDO0.7700.0370.5250.007
Rv3042c.162h77_T3_A_1PDBCREDO0.5420.2550.5250.007
Rv3042c.162oiq_STI_A_1001PDBCREDO0.6330.1420.5240.008
Rv3042c.143d1x_ROC_A_201PDBCREDO0.5810.2030.5230.008
Rv3042c.161uwj_BAX_B_1723PDBCREDO0.6500.1240.5220.008
Rv3042c.163gcs_BAX_A_401PDBCREDO0.6500.1240.5220.008
Rv3042c.162hw2_RFP_A_1200PDBCREDO0.5750.2100.5220.008
Rv3042c.142nmy_ROC_A_401PDBCREDO0.6320.1430.5210.008
Rv3042c.163tne_RIT_B_401PDBCREDO0.5730.2130.5200.008
Rv3042c.161kij_NOV_A_400PDBCREDO0.5550.2370.5190.008
Rv3042c.162pl0_STI_A_200PDBCREDO0.6260.1490.5180.008
Rv3042c.162gqg_1N1_A_501PDBCREDO0.6140.1630.5160.009
Rv3042c.163erd_DES_A_600PDBCREDO0.6140.1630.5160.009
Rv3042c.161fm6_BRL_X_504PDBCREDO0.5510.2430.5160.009
Rv3042c.163erd_DES_B_800PDBCREDO0.6120.1650.5150.009
Rv3042c.161jg3_ADN_A_500PDBCREDO0.6340.1410.5140.009
Rv3042c.163qlg_1N1_A_601PDBCREDO0.7070.0750.5130.009
Rv3042c.164eyb_0WO_A_303PDBCREDO0.5880.1940.5130.009
Rv3042c.143cyx_ROC_A_201PDBCREDO0.6340.1400.5110.009
Rv3042c.143ndu_ROC_D_100PDBCREDO0.6340.1410.5110.009
Rv3042c.143tkw_017_B_401PDBCREDO0.5800.2040.5110.009
Rv3042c.162gqg_1N1_B_502PDBCREDO0.5100.3020.5100.009
Rv3042c.163qlg_1N1_B_601PDBCREDO0.7040.0770.5100.009
Rv3042c.142f8g_017_B_401PDBCREDO0.5550.2370.5100.009
Rv3042c.143s54_017_B_201PDBCREDO0.5540.2380.5100.009
Rv3042c.161fm6_BRL_D_503PDBCREDO0.5830.2000.5090.010
Rv3042c.162zva_1N1_A_513PDBCREDO0.7300.0600.5090.010
Rv3042c.161lhv_NOG_A_301PDBCREDO0.5420.2550.5080.010
Rv3042c.143sm2_478_A_126PDBCREDO0.7630.0410.5070.010
Rv3042c.161t7j_478_A_200PDBCREDO0.5940.1860.5070.010
Rv3042c.162cbr_A80_A_201PDBCREDO0.6480.1270.5070.010
Rv3042c.163g5d_1N1_A_1PDBCREDO0.6990.0810.5070.010
Rv3042c.162prg_BRL_A_1PDBCREDO0.5800.2040.5050.010
Rv3042c.163bbt_FMM_B_91PDBCREDO0.6710.1050.5050.010
Rv3042c.163h0a_9RA_A_500PDBCREDO0.5400.2580.5050.010
Rv3042c.163pyy_STI_B_4PDBCREDO0.6660.1090.5050.010
Rv3042c.161uwj_BAX_A_1723PDBCREDO0.6850.0920.5050.010
Rv3042c.142aof_FRD_C_305PDBCREDO0.6560.1190.5050.010
Rv3042c.143tkg_ROC_C_901PDBCREDO0.6410.1330.5050.010
Rv3042c.163k5v_STI_B_2PDBCREDO0.6650.1100.5040.010
Rv3042c.163g5d_1N1_B_1PDBCREDO0.6950.0840.5040.010
Rv3042c.142q64_1UN_B_1001PDBCREDO0.7390.0540.5030.010
Rv3042c.143ucb_017_A_201PDBCREDO0.6860.0920.5030.010
Rv3042c.142qak_1UN_A_1001PDBCREDO0.7380.0550.5030.010
Rv3042c.162hyy_STI_A_600PDBCREDO0.6630.1120.5030.010
Rv3042c.163ms9_STI_A_1PDBCREDO0.6630.1120.5030.010
Rv3042c.163ms9_STI_B_1PDBCREDO0.6630.1120.5030.010
Rv3042c.142nmz_ROC_B_401PDBCREDO0.6570.1180.5020.011
Rv3042c.142pyn_1UN_A_1001PDBCREDO0.7370.0560.5020.011
Rv3042c.142pym_1UN_A_1001PDBCREDO0.7360.0560.5020.011
Rv3042c.162hyy_STI_C_600PDBCREDO0.6620.1130.5010.011
Rv3042c.163mss_STI_D_1PDBCREDO0.6620.1130.5010.011
Rv3042c.163mss_STI_A_1PDBCREDO0.6610.1140.5010.011
Rv3042c.163mss_STI_B_1PDBCREDO0.6610.1140.5010.011
Rv3042c.142q63_1UN_A_1001PDBCREDO0.7350.0570.5010.011
Rv3042c.163gvu_STI_A_1001PDBCREDO0.6610.1140.5010.011
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
phosphatePubChem0.96896.9872
O-phosphoserinePubChem0.967185.072
L-serinePubChem0.956105.093
hydroxyl radicalsPubChem0.917.0073
magnesiumPubChem0.80924.305
chloridePubChem0.77235.453
sulfatePubChem0.76896.0626
hydron sulfatePubChem0.768196.157
selenomethioninePubChem0.757196.106
SeMetPubChem0.757196.106