Rv1077

Tuberculist information
Gene namecbs
Protein functionProbable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1201.72
Molecular mass(da)48635.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 464
	  		  	1    MRIAQHISELIGGTPLVRLNSVVPDGAGTVAAKVEYLNPGGSSKDRIAVKMIEAAEASGQ   60
			  	61   LKPGGTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSEDKRNVLIAYGAEVVVCPTAV  120
			  	121  PPHDPASYYSVSDRLVRDIDGAWKPDQYANPEGPASHYVTTGPEIWADTEGKVTHFVAGI  180
			  	181  GTGGTITGAGRYLKEVSGGRVRIVGADPEGSVYSGGAGRPYLVEGVGEDFWPAAYDPSVP  240
			  	241  DEIIAVSDSDSFDMTRRLAREEAMLVGGSCGMAVVAALKVAEEAGPDALIVVLLPDGGRG  300
			  	301  YMSKIFNDAWMSSYGFLRSRLDGSTEQSTVGDVLRRKSGALPALVHTHPSETVRDAIGIL  360
			  	361  REYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRAKLADAVSAHMSPPLRMIGAG  420
			  	421  ELVSAAGKALRDWDALMVVEEGKPVGVITRYDLLGFLSEGAGRR

Known structures in the PDB
No Known structures
1 47 93 139 185 231 277 323 369 415 461 Range: 7 to 296  |  Coverage: 62% PALP Range: 330 to 397  |  Coverage: 14% CBS Range: 406 to 459  |  Coverage: 11% CBS Range: 2 to 314  |  Coverage: 67% 1 Range: 7 to 296  |  Coverage: 62% 1
Number of amino acids : 464
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PALPPF002917-296
CBSPF00571330-397
CBSPF00571406-459
Mtb Structural Proteome models
Model Number1
Model nameRv1077
Template1JBQ    APDBCREDO
Template coverage75_394
Template Identity(%)45.0
Model coverage(%)67.2
Normalized DOPE score-0.687

Structure Models from Chopin
Model Number1
Profilec.79.1.1
Click for model details
zscore32.31
Residue begin7
Residue end296
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1077Gene nameConfidence Score
Rv1079metB0.995
Rv2335cysE0.985
Rv2335cysE0.985
Rv3340metC0.969
Rv2124cmetH0.961
Rv2124cmetH0.961
Rv2124cmetH0.961
Rv2124cmetH0.961
Rv2124cmetH0.961
Rv0391metZ0.958
Rv1133cmetE0.952
Rv1133cmetE0.952
Rv3248csahH0.941
Rv3248csahH0.941
Rv1612trpB0.934
Rv1093glyA10.931
Rv0070cglyA20.93
Rv1613trpA0.922
Rv3042cserB20.921
Rv3042cserB20.921
Rv1559ilvA0.918
Rv1559ilvA0.918
Rv2458mmuM0.916
Rv0069csdaA0.903
Rv0069csdaA0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
homocysteinePubChem0.954135.185
cystathioninePubChem0.954222.262
sulphurPubChem0.95334.0809
S-adenosylhomocysteinePubChem0.945384.411
L-serinePubChem0.943105.093
half-cystinePubChem0.942121.158
L-homocysteinePubChem0.934135.185
L-cystathioninePubChem0.93222.262
cysteinatePubChem0.926121.158
acetatePubChem0.92359.044
alpha-ketobutyratePubChem0.922102.089
selenocystathioninePubChem0.917269.157
H(+)PubChem0.9112.01588
adenosinePubChem0.905267.241
ammoniaPubChem0.90517.0305
O-acetyl-L-homoserinePubChem0.905161.156
deuteriumPubChem0.9042.01588
C05698PubChem0.9182.08
DL-serinePubChem0.9105.093
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
pyruvic acidPubChem0.988.0621
pyridoxal phosphatePubChem0.818247.142