Rv2458

Tuberculist information
Gene namemmuM
Protein functionProbable homocysteine S-methyltransferase MmuM (S-methylmethionine:homocysteine methyltransferase) (cysteine methyltransferase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2759.78
Molecular mass(da)31560.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 302
	  		  	1    VELVSDSVLISDGGLATELEARGHDLSDPLWSARLLVDAPHAITAVHTAYFRAGAQIATT   60
			  	61   ASYQASFEGFAARGIGHDDATVLLRRSVELAQAARDEVGVGGLSVAASVGPYGAALADGS  120
			  	121  EYRGYYGLSVAALMKWHLPRLEVLVDAGADMLALETIPDIDEAEALVNLVRRLATPAWLS  180
			  	181  YTINGTRTRAGQPLTDAFAVAAGVPEIVAVGVNCCAPDDVLPAIAFAVAHTGKPVIVYPN  240
			  	241  SGEGWDGRRRAWVGPRRFSGSSGQLAREWVAAGARIVGGCCRVRPIDIAEIGRALTTAPP  300
			  	301  RG

Known structures in the PDB
No Known structures
1 31 61 91 121 151 181 211 241 271 301 Range: 8 to 297  |  Coverage: 95% S-methyl_trans Range: 2 to 300  |  Coverage: 98% 1 Range: 1 to 302  |  Coverage: 99% 1
Number of amino acids : 302
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
S-methyl_transPF025748-297
Mtb Structural Proteome models
Model Number1
Model nameRv2458
Template1Q7Z    APDBCREDO
Template coverage9_292
Template Identity(%)27.8
Model coverage(%)98.7
Normalized DOPE score-0.016

Structure Models from Chopin
Model Number1
Profile3.20.20.330
Click for model details
zscore42.13
Residue begin1
Residue end302
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2458Gene nameConfidence Score
Rv1392metK0.982
Rv1392metK0.982
Rv1392metK0.982
Rv3248csahH0.957
Rv3248csahH0.957
Rv3340metC0.948
Rv1079metB0.934
Rv0391metZ0.925
Rv1077cbs0.916
Rv1077cbs0.916
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
homocysteinePubChem0.973135.185
L-homocysteinePubChem0.901135.185
L-methioninePubChem0.9149.211
S-methylmethioninePubChem0.707164.246