Rv1079

Tuberculist information
Gene namemetB
Protein functionCystathionine gamma-synthase MetB (CGS) (O-succinylhomoserine [thiol]-lyase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1204.07
Molecular mass(da)40982.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 388
	  		  	1    MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTG   60
			  	61   NPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDK  120
			  	121  VFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKV  180
			  	181  LVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG  240
			  	241  AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAA  300
			  	301  RQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQL  360
			  	361  EVPDDLVRLSVGIEDIADLLGDLEQALG

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 15 to 388  |  Coverage: 96% Cys_Met_Meta_PP Range: 12 to 387  |  Coverage: 96% 1 Range: 1 to 388  |  Coverage: 99% 1
Number of amino acids : 388
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Cys_Met_Meta_PPPF0105315-388
Mtb Structural Proteome models
Model Number1
Model nameRv1079
Template1IBJ    APDBCREDO
Template coverage85_459
Template Identity(%)42.1
Model coverage(%)96.6
Normalized DOPE score-0.359

Structure Models from Chopin
Model Number1
Profilec.67.1.3
Click for model details
zscore28.39
Residue begin1
Residue end388
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1079Gene nameConfidence Score
Rv1133cmetE0.998
Rv1133cmetE0.998
Rv1077cbs0.995
Rv1077cbs0.995
Rv3341metA0.994
Rv2124cmetH0.982
Rv2124cmetH0.982
Rv2124cmetH0.982
Rv2124cmetH0.982
Rv2124cmetH0.982
Rv3340metC0.956
Rv0391metZ0.952
Rv3248csahH0.951
Rv3248csahH0.951
Rv0075Rv00750.949
Rv1296thrB0.942
Rv1296thrB0.942
Rv2334cysK10.94
Rv1294thrA0.938
Rv1294thrA0.938
Rv1294thrA0.938
Rv2294Rv22940.936
Rv2458mmuM0.934
Rv1464csd0.921
Rv2335cysE0.908
Rv2335cysE0.908
Rv1392metK0.902
Rv1392metK0.902
Rv1392metK0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
cystathioninePubChem0.991222.262
homocysteinePubChem0.975135.185
O-succinylhomoserinePubChem0.97219.192
L-homocysteinePubChem0.963135.185
homoserinePubChem0.962119.119
half-cystinePubChem0.953121.158
L-cystathioninePubChem0.952222.262
alpha-ketobutyratePubChem0.945102.089
O-acetyl-L-homoserinePubChem0.935161.156
L-homoserinePubChem0.933119.119
cysteine sulfinic acidPubChem0.928153.157
cysteinesulfinic acidPubChem0.928152.149
pyridoxal phosphatePubChem0.923247.142
L-serinePubChem0.92105.093
cysteinatePubChem0.92121.158
selenocystathioninePubChem0.919269.157
ammoniaPubChem0.91517.0305
pyruvic acidPubChem0.9188.0621
deuteriumPubChem0.9082.01588
DL-serinePubChem0.906105.093
succinatePubChem0.904118.088
suc-coaPubChem0.9867.607
molecular oxygenPubChem0.931.9988
acetatePubChem0.959.044
Co-APubChem0.9767.534
carbon dioxidePubChem0.944.0095
L-selenocysteinePubChem0.9168.053
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
protiumPubChem0.92.01576
n-propionyl-CoAPubChem0.9823.597
hydroxyl radicalsPubChem0.917.0073
propionyl-CoAPubChem0.9823.597
coenzyme APubChem0.9767.534
H(+)PubChem0.92.01588
NAD+PubChem0.9663.425
succinyl-CoAPubChem0.9867.607
succinyl-homoserinePubChem0.9219.192
propargylglycinePubChem0.846113.115