Rv1464

Tuberculist information
Gene namecsd
Protein functionProbable cysteine desulfurase Csd
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1651.52
Molecular mass(da)44596.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 417
	  		  	1    MTASVNSLDLAAIRADFPILKRIMRGGNPLAYLDSGATSQRPLQVLDAEREFLTASNGAV   60
			  	61   HRGAHQLMEEATDAYEQGRADIALFVGADTDELVFTKNATEALNLVSYVLGDSRFERAVG  120
			  	121  PGDVIVTTELEHHANLIPWQELARRTGATLRWYGVTDDGRIDLDSLYLDDRVKVVAFTHH  180
			  	181  SNVTGVLTPVSELVSRAHQSGALTVLDACQSVPHQPVDLHELGVDFAAFSGHKMLGPNGI  240
			  	241  GVLYGRRELLAQMPPFLTGGSMIETVTMEGATYAPAPQRFEAGTPMTSQVVGLAAAARYL  300
			  	301  GAIGMAAVEAHERELVAAAIEGLSGIDGVRILGPTSMRDRGSPVAFVVEGVHAHDVGQVL  360
			  	361  DDGGVAVRVGHHCALPLHRRFGLAATARASFAVYNTADEVDRLVAGVRRSRHFFGRA

Known structures in the PDB
No Known structures
1 42 83 124 165 206 247 288 329 370 411 Range: 31 to 403  |  Coverage: 89% Aminotran_5 Range: 13 to 415  |  Coverage: 96% 1 Range: 1 to 417  |  Coverage: 99% 1
Number of amino acids : 417
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Aminotran_5PF0026631-403
Mtb Structural Proteome models
Model Number1
Model nameRv1464
Template1JF9    APDBCREDO
Template coverage8_406
Template Identity(%)46.4
Model coverage(%)96.4
Normalized DOPE score-0.818

Structure Models from Chopin
Model Number1
Profilec.67.1.3
Click for model details
zscore26.09
Residue begin1
Residue end417
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1464Gene nameConfidence Score
Rv1463Rv14630.999
Rv1465Rv14650.998
Rv1461Rv14610.998
Rv1461Rv14610.998
Rv1462Rv14620.997
Rv1466Rv14660.989
Rv1460Rv14600.984
Rv2204cRv2204c0.967
Rv3284Rv32840.938
Rv3913trxB20.93
Rv3913trxB20.93
Rv1079metB0.921
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-selenocysteinePubChem0.972168.053
half-cystinePubChem0.961121.158
L-alaninePubChem0.93689.0932
pyridoxal phosphatePubChem0.817247.142
4Fe-4SPubChem0.76688.9179