Tuberculist information
Gene nameRv1461
Protein functionConserved protein
Functional category(tuberculist)conserved hypotheticals
Gene location(kb)1646.99
Molecular mass(da)94171.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 846
	  		  	1    MTLTPEASKSVAQPPTQAPLTQEEAIASLGRYGYGWADSDVAGANAQRGLSEAVVRDISA   60
			  	61   KKNEPDWMLQSRLKALRIFDRKPIPKWGSNLDGIDFDNIKYFVRSTEKQAASWDDLPEDI  120
			  	121  RNTYDRLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEAQGVIFLDTDTGLREHPDIFK  180
			  	181  EYFGTVIPAGDNKFSALNTAVWSGGSFIYVPPGVHVDIPLQAYFRINTENMGQFERTLII  240
			  	241  ADEGSYVHYVEGCLPAGELITTADGDLRPIESIRVGDFVTGHDGRPHRVTAVQVRDLDGE  300
			  	301  LFTFTPMSPANAFSVTAEHPLLAIPRDEVRVMRKERNGWKAEVNSTKLRSAEPRWIAAKD  360
			  	361  VAEGDFLIYPKPKPIPHRTVLPLEFARLAGYYLAEGHACLTNGCESLIFSFHSDEFEYVE  420
			  	421  DVRQACKSLYEKSGSVLIEEHKHSARVTVYTKAGYAAMRDNVGIGSSNKKLSDLLMRQDE  480
			  	481  TFLRELVDAYVNGDGNVTRRNGAVWKRVHTTSRLWAFQLQSILARLGHYATVELRRPGGP  540
			  	541  GVIMGRNVVRKDIYQVQWTEGGRGPKQARDCGDYFAVPIKKRAVREAHEPVYNLDVENPD  600
			  	601  SYLAYGFAVHNCTAPIYKSDSLHSAVVEIIVKPHARVRYTTIQNWSNNVYNLVTKRARAE  660
			  	661  AGATMEWIDGNIGSKVTMKYPAVWMTGEHAKGEVLSVAFAGEDQHQDTGAKMLHLAPNTS  720
			  	721  SNIVSKSVARGGGRTSYRGLVQVNKGAHGSRSSVKCDALLVDTVSRSDTYPYVDIREDDV  780
			  	781  TMGHEATVSKVSENQLFYLMSRGLTEDEAMAMVVRGFVEPIAKELPMEYALELNRLIELQ  840
			  	841  MEGAVG
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Hom_end_hintPF05203253-367
UPF0051PF01458601-817
Mtb Structural Proteome models
Model Number1
Model nameRv1461.3
Template1VH4    APDBCREDO
Template coverage141_421
Template Identity(%)20.4
Model coverage(%)31.7
Normalized DOPE score-0.125

Model Number2
Model nameRv1461
Template2CW8    APDBCREDO
Template coverage11_534
Template Identity(%)16.0
Model coverage(%)55.9
Normalized DOPE score0.691

Structure Models from Chopin
Model Number1
Profileb.80.6.1
Click for model details
zscore50.71
Residue begin601
Residue end817
Model Number2
Profileb.80.6.1
Click for model details
zscore22.75
Residue begin450
Residue end844
Model Number3
Profileb.86.1.2 - 2.170.16.10
Click for model details
zscore13.41
Residue begin253
Residue end367
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1461Gene nameConfidence Score
Rv1463Rv14630.999
Rv1464csd0.998
Rv1465Rv14650.998
Rv1466Rv14660.995
Rv1462Rv14620.994
Rv1460Rv14600.978
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv1461.352fum_MIX_C_2539PDBCREDO0.6510.1240.6000.002
Rv1461.361lhu_EST_A_301PDBCREDO0.6390.1350.5950.002
Rv1461.321fk9_EFZ_A_999PDBCREDO0.6060.1720.5830.003
Rv1461.321lw0_NVP_A_999PDBCREDO0.6050.1720.5820.003
Rv1461.362h42_VIA_B_902PDBCREDO0.5990.1810.5770.003
Rv1461.321klm_SPP_A_999PDBCREDO0.6200.1560.5740.003
Rv1461.353g5d_1N1_A_1PDBCREDO0.6390.1350.5670.004
Rv1461.353qlg_1N1_A_601PDBCREDO0.6390.1350.5670.004
Rv1461.353qlg_1N1_B_601PDBCREDO0.6390.1360.5660.004
Rv1461.352zva_1N1_A_513PDBCREDO0.6130.1640.5650.004
Rv1461.363k54_1N1_A_1PDBCREDO0.5650.2230.5650.004
Rv1461.353g5d_1N1_B_1PDBCREDO0.6360.1390.5640.004
Rv1461.361ya3_STR_C_3001PDBCREDO0.5620.2270.5620.004
Rv1461.352fum_MIX_B_1539PDBCREDO0.5840.1980.5610.004
Rv1461.3162y7j_B49_B_1294PDBCREDO0.5800.2030.5580.004
Rv1461.322y7j_B49_B_1294PDBCREDO0.6000.1790.5540.005
Rv1461.351m17_AQ4_A_999PDBCREDO0.5530.2400.5530.005
Rv1461.362h42_VIA_C_903PDBCREDO0.5730.2130.5530.005
Rv1461.363h52_486_C_4PDBCREDO0.5720.2150.5510.005
Rv1461.361a27_EST_A_350PDBCREDO0.6170.1590.5510.005
Rv1461.363kw2_ADN_A_300PDBCREDO0.5700.2170.5490.005
Rv1461.352itz_IRE_A_2021PDBCREDO0.5710.2150.5490.005
Rv1461.3162zva_1N1_A_513PDBCREDO0.5470.2490.5470.005
Rv1461.351fmo_ADN_E_351PDBCREDO0.5690.2180.5460.005
Rv1461.352y7j_B49_B_1294PDBCREDO0.5690.2180.5460.005
Rv1461.3103g0e_B49_A_9000PDBCREDO0.5460.2490.5460.005
Rv1461.321s9p_DES_B_459PDBCREDO0.5680.2200.5460.005
Rv1461.362gqg_1N1_A_501PDBCREDO0.5640.2240.5440.006
Rv1461.322j7y_E3O_A_1454PDBCREDO0.5640.2250.5430.006
Rv1461.352ity_IRE_A_2020PDBCREDO0.5880.1930.5430.006
Rv1461.363aod_RFP_C_2002PDBCREDO0.5420.2550.5420.006
Rv1461.352y7j_B49_D_1294PDBCREDO0.6430.1310.5420.006
Rv1461.321s9p_DES_C_500PDBCREDO0.5630.2260.5410.006
Rv1461.363jwq_VIA_B_901PDBCREDO0.5610.2290.5410.006
Rv1461.321lwf_NVP_A_999PDBCREDO0.6360.1390.5410.006
Rv1461.353kw2_ADN_B_300PDBCREDO0.5860.1960.5400.006
Rv1461.323ti1_B49_A_299PDBCREDO0.5380.2600.5380.006
Rv1461.363rif_IVM_E_402PDBCREDO0.5790.2050.5370.006
Rv1461.321lwc_NVP_A_999PDBCREDO0.6310.1440.5370.006
Rv1461.321s1u_NVP_A_999PDBCREDO0.6310.1440.5370.006
Rv1461.361a28_STR_A_1PDBCREDO0.5760.2080.5360.006
Rv1461.364eb6_VLB_C_503PDBCREDO0.5560.2360.5360.006
Rv1461.322hny_NVP_A_999PDBCREDO0.6290.1460.5350.006
Rv1461.363ri5_IVM_B_349PDBCREDO0.5750.2100.5340.006
Rv1461.363rhw_IVM_D_349PDBCREDO0.5750.2110.5330.007
Rv1461.363ria_IVM_A_348PDBCREDO0.5750.2110.5330.007
Rv1461.363rhw_IVM_B_348PDBCREDO0.5740.2110.5330.007
Rv1461.363rhw_IVM_B_349PDBCREDO0.5740.2110.5330.007
Rv1461.363ri5_IVM_D_349PDBCREDO0.5740.2110.5330.007
Rv1461.3162x1l_ADN_C_601PDBCREDO0.6860.0920.5330.007
Rv1461.363kw2_ADN_B_300PDBCREDO0.6200.1560.5320.007
Rv1461.322x1l_ADN_C_601PDBCREDO0.7120.0720.5320.007
Rv1461.323hvt_NVP_A_557PDBCREDO0.6250.1500.5320.007
Rv1461.363rhw_IVM_D_348PDBCREDO0.5730.2130.5310.007
Rv1461.363rif_IVM_A_402PDBCREDO0.5510.2430.5310.007
Rv1461.361lhv_NOG_A_301PDBCREDO0.6980.0820.5310.007
Rv1461.361ya3_STR_B_2001PDBCREDO0.5910.1900.5310.007
Rv1461.363rif_IVM_D_402PDBCREDO0.5500.2440.5310.007
Rv1461.361p93_DEX_B_2999PDBCREDO0.6110.1660.5300.007
Rv1461.351mx1_THA_A_1PDBCREDO0.5520.2410.5300.007
Rv1461.353grv_ADN_A_300PDBCREDO0.6900.0890.5300.007
Rv1461.361p93_DEX_A_1999PDBCREDO0.6100.1670.5300.007
Rv1461.353k54_1N1_A_1PDBCREDO0.6680.1070.5290.007
Rv1461.351sn5_T3_C_601PDBCREDO0.5510.2430.5280.007
Rv1461.363sxr_1N1_A_1PDBCREDO0.6150.1620.5280.007
Rv1461.363rif_IVM_B_403PDBCREDO0.5470.2480.5280.007
Rv1461.322zia_CL9_A_401PDBCREDO0.5280.2760.5280.007
Rv1461.361ya3_STR_A_1001PDBCREDO0.5870.1950.5270.007
Rv1461.363ri5_IVM_C_350PDBCREDO0.5460.2490.5270.007
Rv1461.363ria_IVM_C_350PDBCREDO0.5670.2200.5270.007
Rv1461.363ria_IVM_E_348PDBCREDO0.5670.2200.5270.007
Rv1461.322zva_1N1_A_513PDBCREDO0.5470.2480.5260.007
Rv1461.323qip_NVP_A_561PDBCREDO0.6190.1570.5260.007
Rv1461.363ria_IVM_C_349PDBCREDO0.5450.2500.5260.007
Rv1461.353adx_IMN_B_3PDBCREDO0.5470.2490.5250.007
Rv1461.352fum_MIX_A_539PDBCREDO0.6870.0910.5250.007
Rv1461.351ie4_T44_A_128PDBCREDO0.5250.2810.5250.007
Rv1461.3161pg2_ADN_A_552PDBCREDO0.7400.0540.5240.008
Rv1461.361jin_KTN_A_801PDBCREDO0.6100.1670.5240.008
Rv1461.322hnd_NVP_A_999PDBCREDO0.6150.1610.5230.008
Rv1461.361oq5_CEL_A_701PDBCREDO0.5430.2540.5230.008
Rv1461.352uxo_TAC_B_1211PDBCREDO0.5440.2520.5220.008
Rv1461.3102xn7_T44_A_1355PDBCREDO0.5220.2840.5220.008
Rv1461.361mx1_THA_C_3PDBCREDO0.5610.2290.5220.008
Rv1461.322cbr_A80_A_201PDBCREDO0.5630.2270.5210.008
Rv1461.353oht_1N1_A_1000PDBCREDO0.6340.1400.5210.008
Rv1461.362q1v_PDN_A_248PDBCREDO0.5800.2040.5210.008
Rv1461.3102o7o_DXT_A_222PDBCREDO0.5210.2860.5210.008
Rv1461.3101uho_VDN_A_1000PDBCREDO0.5650.2240.5200.008
Rv1461.351mx1_THA_B_2PDBCREDO0.5200.2880.5200.008
Rv1461.3161fk9_EFZ_A_999PDBCREDO0.5190.2890.5190.008
Rv1461.353sxr_1N1_B_2PDBCREDO0.5410.2570.5190.008
Rv1461.363ri5_IVM_E_349PDBCREDO0.6040.1740.5190.008
Rv1461.3102trt_TAC_A_222PDBCREDO0.5180.2900.5180.008
Rv1461.362fum_MIX_A_539PDBCREDO0.5370.2620.5180.008
Rv1461.3101jip_KTN_A_801PDBCREDO0.5390.2590.5180.008
Rv1461.3102iyf_ERY_A_1400PDBCREDO0.5180.2910.5180.008
Rv1461.362aa5_STR_B_302PDBCREDO0.6380.1370.5170.008
Rv1461.3102xn6_T44_A_1370PDBCREDO0.5170.2930.5170.008
Rv1461.3103sxr_1N1_B_2PDBCREDO0.5170.2930.5170.008
Rv1461.363nrr_D16_B_520PDBCREDO0.5750.2100.5170.008
Rv1461.3163ti1_B49_A_299PDBCREDO0.5370.2620.5170.008
Rv1461.363ls4_TCI_H_220PDBCREDO0.6020.1770.5160.008
Rv1461.363nrr_D16_B_530PDBCREDO0.6260.1490.5160.008
Rv1461.362aa5_STR_A_301PDBCREDO0.6360.1380.5160.009
Rv1461.363ri5_IVM_A_349PDBCREDO0.5560.2360.5160.009
Rv1461.3101uof_PNN_A_1312PDBCREDO0.5150.2950.5150.009
Rv1461.3103fuu_ADN_A_0PDBCREDO0.5580.2340.5150.009
Rv1461.3103k2h_LYA_A_514PDBCREDO0.5580.2340.5150.009
Rv1461.363k2h_LYA_B_514PDBCREDO0.5540.2390.5150.009
Rv1461.363ria_IVM_E_349PDBCREDO0.5540.2390.5140.009
Rv1461.363sxr_1N1_B_2PDBCREDO0.6230.1530.5140.009
Rv1461.352ito_IRE_A_2020PDBCREDO0.6020.1770.5140.009
Rv1461.3161ki3_PE2_A_1PDBCREDO0.5140.2970.5140.009
Rv1461.351mx1_THA_F_6PDBCREDO0.5560.2350.5130.009
Rv1461.361fdu_EST_C_353PDBCREDO0.5740.2120.5120.009
Rv1461.363rhw_IVM_A_348PDBCREDO0.5520.2410.5120.009
Rv1461.361uho_VDN_A_1000PDBCREDO0.6740.1020.5120.009
Rv1461.351mx1_THA_D_4PDBCREDO0.5540.2380.5110.009
Rv1461.361jg3_ADN_A_500PDBCREDO0.5110.3010.5110.009
Rv1461.3101xos_VIA_A_1PDBCREDO0.5790.2050.5110.009
Rv1461.3161s9p_DES_B_459PDBCREDO0.5110.3020.5110.009
Rv1461.3161s9p_DES_C_500PDBCREDO0.5110.3020.5110.009
Rv1461.3103nrr_D16_B_530PDBCREDO0.5100.3030.5100.009
Rv1461.3101fr6_AZR_B_362PDBCREDO0.5740.2120.5100.009
Rv1461.321jkh_EFZ_A_999PDBCREDO0.5990.1800.5100.009
Rv1461.322vuf_FUA_A_2001PDBCREDO0.6250.1500.5100.009
Rv1461.363rif_IVM_A_403PDBCREDO0.5290.2750.5100.009
Rv1461.321kij_NOV_B_444PDBCREDO0.5290.2740.5090.009
Rv1461.351kij_NOV_B_444PDBCREDO0.5970.1830.5090.009
Rv1461.364eb4_D16_A_402PDBCREDO0.5090.3040.5090.009
Rv1461.363oct_1N1_A_663PDBCREDO0.5650.2230.5080.010
Rv1461.333ucb_017_B_202PDBCREDO0.5810.2020.5080.010
Rv1461.353kw2_ADN_A_300PDBCREDO0.6170.1590.5070.010
Rv1461.3161klm_SPP_A_999PDBCREDO0.5690.2180.5070.010
Rv1461.3102riw_T44_A_1395PDBCREDO0.5510.2430.5070.010
Rv1461.353lfa_1N1_A_361PDBCREDO0.5280.2750.5070.010
Rv1461.352gqg_1N1_A_501PDBCREDO0.6630.1120.5060.010
Rv1461.3102ydo_ADN_A_400PDBCREDO0.5990.1800.5060.010
Rv1461.3103u9f_CLM_K_221PDBCREDO0.5270.2770.5060.010
Rv1461.353ads_IMN_B_3PDBCREDO0.5500.2430.5060.010
Rv1461.3101jin_KTN_A_801PDBCREDO0.5270.2780.5060.010
Rv1461.364eyb_0WO_B_301PDBCREDO0.5060.3090.5060.010
Rv1461.321ki3_PE2_A_1PDBCREDO0.5250.2790.5050.010
Rv1461.3101a27_EST_A_350PDBCREDO0.5470.2480.5050.010
Rv1461.3163qlg_1N1_A_601PDBCREDO0.5250.2790.5050.010
Rv1461.362h42_VIA_A_901PDBCREDO0.5820.2010.5050.010
Rv1461.363jwq_VIA_D_901PDBCREDO0.5820.2010.5050.010
Rv1461.352fum_MIX_D_3539PDBCREDO0.7340.0570.5040.010
Rv1461.3161lw0_NVP_A_999PDBCREDO0.5040.3120.5040.010
Rv1461.362aa6_STR_A_401PDBCREDO0.6210.1550.5040.010
Rv1461.361fr6_AZR_A_362PDBCREDO0.5430.2540.5040.010
Rv1461.322zi9_CL9_A_401PDBCREDO0.5630.2260.5030.010
Rv1461.363apv_TP0_A_190PDBCREDO0.5030.3140.5030.010
Rv1461.3103u9f_CLM_J_221PDBCREDO0.5440.2520.5030.010
Rv1461.362aax_PDN_B_503PDBCREDO0.6200.1560.5030.010
Rv1461.362cbr_A80_A_201PDBCREDO0.5210.2860.5020.011
Rv1461.364e3a_ADN_B_500PDBCREDO0.5210.2860.5020.011
Rv1461.364eb4_D16_B_402PDBCREDO0.5410.2560.5020.011
Rv1461.3163qlg_1N1_B_601PDBCREDO0.5220.2840.5020.011
Rv1461.361nhz_486_A_800PDBCREDO0.5990.1810.5020.011
Rv1461.3161kij_NOV_B_444PDBCREDO0.5430.2540.5020.011
Rv1461.353sxr_1N1_A_1PDBCREDO0.5440.2520.5020.011
Rv1461.363vri_1KX_A_301PDBCREDO0.5840.1980.5020.011
Rv1461.362aa6_STR_B_402PDBCREDO0.6180.1580.5020.011
Rv1461.3101i2w_CFX_A_1300PDBCREDO0.5010.3160.5010.011
Rv1461.363f4x_KLT_A_300PDBCREDO0.5400.2580.5010.011
Rv1461.323qlg_1N1_A_601PDBCREDO0.5010.3170.5010.011
Rv1461.322a7q_CFB_A_328PDBCREDO0.5200.2870.5010.011
Rv1461.3101fr6_AZR_A_362PDBCREDO0.5630.2260.5010.011
Rv1461.361dwc_MIT_H_1PDBCREDO0.5390.2590.5000.011
Rv1461.361mx1_THA_E_5PDBCREDO0.5000.3180.5000.011
Rv1461.362w9s_TOP_D_1158PDBCREDO0.6590.1160.5000.011
Rv1461.363k2h_LYA_A_514PDBCREDO0.5600.2300.5000.011
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions