Rv1460

Tuberculist information
Gene nameRv1460
Protein functionProbable transcriptional regulatory protein
Functional category(tuberculist)regulatory proteins
Gene location(kb)1646.19
Molecular mass(da)28147.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 268
	  		  	1    VTSTTLPHRASLVDRSTEFCHTDVVKIPAVSTTVPAAVSDGHTRRAIVRLLLESGSITAG   60
			  	61   EIGDRLGLSAAGVRRHLDALIEAGDAEASAAAPWQQVGRGRPAKRYRLTAAGRAKLDHSY  120
			  	121  DDLASAAMRQLREIGGEEAVRTFARRRIDAILADVAPADGPDDAALEAAAERIATALSKA  180
			  	181  GYVATTTRVGGPIHGVQICQHHCPVSHVAEEFPELCETEQQAMAEVLGTHVQRLATIVNG  240
			  	241  DCACTTHVPLSPAPSPRPPATSTEGASR

Known structures in the PDB
No Known structures
1 27 53 79 105 131 157 183 209 235 261 Range: 42 to 84  |  Coverage: 15% HTH_24 Range: 30 to 117  |  Coverage: 32% 1 Range: 5 to 121  |  Coverage: 43% 1 Range: 1 to 242  |  Coverage: 89% 2
Number of amino acids : 268
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HTH_24PF1341242-84
Mtb Structural Proteome models
Model Number1
Model nameRv1460
Template1R1U    APDBCREDO
Template coverage14_100
Template Identity(%)19.5
Model coverage(%)32.5
Normalized DOPE score-0.674

Structure Models from Chopin
Model Number1
Profilea.4.5.5 - 1.10.10.10
Click for model details
zscore9.8
Residue begin5
Residue end121
Model Number2
Profilea.4.5.64
Click for model details
zscore8.65
Residue begin1
Residue end242
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1460Gene nameConfidence Score
Rv1463Rv14630.988
Rv1464csd0.984
Rv1466Rv14660.979
Rv1461Rv14610.978
Rv1461Rv14610.978
Rv1462Rv14620.975
Rv1465Rv14650.955
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions