Rv1133c

Tuberculist information
Gene namemetE
Protein functionProbable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE (methionine synthase, vitamin-B12 independent isozyme)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1259.07
Molecular mass(da)81549.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 759
	  		  	1    VTQPVRRQPFTATITGSPRIGPRRELKRATEGYWAGRTSRSELEAVAATLRRDTWSALAA   60
			  	61   AGLDSVPVNTFSYYDQMLDTAVLLGALPPRVSPVSDGLDRYFAAARGTDQIAPLEMTKWF  120
			  	121  DTNYHYLVPEIGPSTTFTLHPGKVLAELKEALGQGIPARPVIIGPITFLLLSKAVDGAGA  180
			  	181  PIERLEELVPVYSELLSLLADGGAQWVQFDEPALVTDLSPDAPALAEAVYTALCSVSNRP  240
			  	241  AIYVATYFGDPGAALPALARTPVEAIGVDLVAGADTSVAGVPELAGKTLVAGVVDGRNVW  300
			  	301  RTDLEAALGTLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGAEKVREV  360
			  	361  VVLARALRDGHDAVADEIASSRAAIASRKRDPRLHNGQIRARIEAIVASGAHRGNAAQRR  420
			  	421  ASQDARLHLPPLPTTTIGSYPQTSAIRVARAALRAGEIDEAEYVRRMRQEITEVIALQER  480
			  	481  LGLDVLVHGEPERNDMVQYFAEQLAGFFATQNGWVQSYGSRCVRPPILYGDVSRPRAMTV  540
			  	541  EWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIA  600
			  	601  VIQVDEPALRELLPLRRADQAEYLRWAVGAFRLATSGVSDATQIHTHLCYSEFGEVIGAI  660
			  	661  ADLDADVTSIEAARSHMEVLDDLNAIGFANGVGPGVYDIHSPRVPSAEEMADSLRAALRA  720
			  	721  VPAERLWVNPDCGLKTRNVDEVTASLHNMVAAAREVRAG

Known structures in the PDB
No Known structures
1 76 151 226 301 376 451 526 601 676 751 Range: 11 to 319  |  Coverage: 40% Meth_synt_1 Range: 432 to 755  |  Coverage: 42% Meth_synt_2 Range: 11 to 758  |  Coverage: 98% 1 Range: 434 to 759  |  Coverage: 42% 1
Number of amino acids : 759
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Meth_synt_1PF0826711-319
Meth_synt_2PF01717432-755
Mtb Structural Proteome models
Model Number1
Model nameRv1133c
Template1U1J    APDBCREDO
Template coverage2_759
Template Identity(%)49.7
Model coverage(%)98.4
Normalized DOPE score-0.518

Structure Models from Chopin
Model Number1
Profilec.1.22.2
Click for model details
zscore46.82
Residue begin434
Residue end759
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1133cGene nameConfidence Score
Rv1392metK0.999
Rv1392metK0.999
Rv1392metK0.999
Rv1079metB0.998
Rv2124cmetH0.992
Rv2124cmetH0.992
Rv2124cmetH0.992
Rv2124cmetH0.992
Rv2124cmetH0.992
Rv3340metC0.988
Rv3248csahH0.985
Rv3248csahH0.985
Rv0391metZ0.975
Rv1007cmetS0.971
Rv0189cilvD0.969
Rv3001cilvC0.952
Rv3001cilvC0.952
Rv1077cbs0.952
Rv1077cbs0.952
Rv1294thrA0.943
Rv1294thrA0.943
Rv1294thrA0.943
Rv1093glyA10.928
Rv0070cglyA20.926
Rv0075Rv00750.924
Rv2538caroB0.913
Rv2294Rv22940.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
homocysteinePubChem0.997135.185
L-homocysteinePubChem0.992135.185
L-methioninePubChem0.975149.211
cystathioninePubChem0.939222.262
S-adenosyl-L-methioninePubChem0.939399.445
5-methyltetrahydrofolatePubChem0.936459.456
methyltetrahydrofolatePubChem0.933459.456
S-adenosyl-methioninePubChem0.921398.437
phosphatePubChem0.90396.9872
sulphurPubChem0.90334.0809
tetrahydropteroyltriglutamatePubChem0.9703.657
L-cystathioninePubChem0.9222.262
acetatePubChem0.959.044
hydroxyl radicalsPubChem0.917.0073
protiumPubChem0.92.01576
adenosine triphosphatePubChem0.9507.181
pyrophosphatePubChem0.9177.975
C04144PubChem0.9703.657
C04489PubChem0.9717.684
O-acetyl-L-homoserinePubChem0.9161.156
deuteriumPubChem0.92.01588
ammoniaPubChem0.917.0305
H(+)PubChem0.92.01588
pyruvic acidPubChem0.988.0621
vitamin B12PubChem0.8481354.36
zincPubChem0.84665.409
selenomethioninePubChem0.759196.106
Tn5PubChem0.743270.111
SeMetPubChem0.733196.106
sulfatePubChem0.73396.0626
hydron sulfatePubChem0.733196.157
ethylene glycol; hydronPubChem0.70463.0758
1,2,3,4-butanetetrolPubChem0.704122.12
erythritolPubChem0.704122.12
polyethylene glycolPubChem0.70462.0678