Rv1826

Tuberculist information
Gene namegcvH
Protein functionProbable glycine cleavage system H protein GcvH
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2071.95
Molecular mass(da)14205.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 134
	  		  	1    VSDIPSDLHYTAEHEWIRRSGDDTVRVGITDYAQSALGDVVFVQLPVIGTAVTAGETFGE   60
			  	61   VESTKSVSDLYAPISGKVSEVNSDLDGTPQLVNSDPYGAGWLLDIQVDSSDVAALESALT  120
			  	121  TLLDAEAYRGTLTE

Known structures in the PDB
No Known structures
1 14 27 40 53 66 79 92 105 118 131 Range: 8 to 134  |  Coverage: 94% GCV_H Range: 22 to 155  |  Coverage: 99% 1 Range: 3 to 133  |  Coverage: 97% 2
Number of amino acids : 134
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GCV_HPF015978-134
Mtb Structural Proteome models
Model Number1
Model nameRv1826_3hgb_A
Template3HGB    APDBCREDO
Template coverage22_155
Template Identity(%)100.0
Model coverage(%)99.3
Normalized DOPE score-1.806

Model Number2
Model nameRv1826
Template1ONL    APDBCREDO
Template coverage2_125
Template Identity(%)53.2
Model coverage(%)97.0
Normalized DOPE score-1.139

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1826Gene nameConfidence Score
Rv2211cgcvT0.999
Rv2211cgcvT0.999
Rv1832gcvB0.996
Rv1832gcvB0.996
Rv2217lipB0.97
Rv1093glyA10.949
Rv0070cglyA20.948
Rv0462lpdC0.912
Rv0462lpdC0.912
Rv0462lpdC0.912
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
tetrahydrofolatePubChem0.834445.429
lipoic acidPubChem0.795206.326
4-O-methyl-alpha-D-glucuronic acidPubChem0.794208.166
sulfatePubChem0.72296.0626
hydron sulfatePubChem0.722196.157
SeMetPubChem0.707196.106
Na(+)PubChem0.70722.9898
selenomethioninePubChem0.707196.106
citratePubChem0.706192.124
ethylene glycol; hydronPubChem0.70663.0758
polyethylene glycolPubChem0.70662.0678
adenosine monophosphatePubChem0.703347.221
hydron diphosphatePubChem0.703391.981
n-octanePubChem0.703114.229
calciumPubChem0.70340.078
methyltetrahydrofolatePubChem0.703459.456
chloridePubChem0.70335.453
5-methyltetrahydrofolatePubChem0.703459.456
phosphatePubChem0.70396.9872