Rv1878

Tuberculist information
Gene nameglnA3
Protein functionProbable glutamine synthetase GlnA3 (glutamine synthase) (GS-I)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2128.02
Molecular mass(da)46720.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 450
	  		  	1    MTATPLAAAAIAQLEAEGVDTVIGTVVNPAGLTQAKTVPIRRTNTFANPGLGASPVWHTF   60
			  	61   CIDQCSIAFTADISVVGDQRLRIDLSALRIIGDGLAWAPAGFFEQDGTPVPACSRGTLSR  120
			  	121  IEAALADAGIDAVIGHEVEFLLVDADGQRLPSTLWAQYGVAGVLEHEAFVRDVNAAATAA  180
			  	181  GIAIEQFHPEYGANQFEISLAPQPPVAAADQLVLTRLIIGRTARRHGLRVSLSPAPFAGS  240
			  	241  IGSGAHQHFSLTMSEGMLFSGGTGAAGMTSAGEAAVAGVLRGLPDAQGILCGSIVSGLRM  300
			  	301  RPGNWAGIYACWGTENREAAVRFVKGGAGSAYGGNVEVKVVDPSANPYLASAAILGLALD  360
			  	361  GMKTKAVLPSETTVDPTQLSDVDRDRAGILRLAADQADAIAVLDSSKLLRCILGDPVVDA  420
			  	421  VVAVRQLEHERYGDLDPAQLADKFRMAWSV

Known structures in the PDB
No Known structures
1 46 91 136 181 226 271 316 361 406 451 Range: 111 to 358  |  Coverage: 54% Gln-synt_C Range: 5 to 450  |  Coverage: 98% 1 Range: 1 to 450  |  Coverage: 99% 1 Range: 6 to 113  |  Coverage: 23% 2
Number of amino acids : 450
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Gln-synt_CPF00120111-358
Mtb Structural Proteome models
Model Number1
Model nameRv1878
Template2BVC    APDBCREDO
Template coverage4_478
Template Identity(%)24.4
Model coverage(%)98.9
Normalized DOPE score0.328

Structure Models from Chopin
Model Number1
Profiled.128.1.1
Click for model details
zscore45.85
Residue begin1
Residue end450
Model Number2
Profile3.10.20.70
Click for model details
zscore14.38
Residue begin6
Residue end113
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1878Gene nameConfidence Score
Rv1879Rv18790.997
Rv3704cgshA0.975
Rv3859cgltB0.964
Rv3859cgltB0.964
Rv3859cgltB0.964
Rv3859cgltB0.964
Rv0253nirD0.926
Rv0252nirB0.925
Rv0252nirB0.925
Rv0252nirB0.925
Rv0252nirB0.925
Rv0252nirB0.925
Rv3858cgltD0.901
Rv2391sirA0.901
Rv2391sirA0.901
Rv3858cgltD0.901
Rv3858cgltD0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
polyglutaminePubChem0.942146.145
glutamatePubChem0.923147.129
ammoniaPubChem0.90217.0305