Rv3704c

Tuberculist information
Gene namegshA
Protein functionGlutamate--cysteine ligase GshA (gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS) (gamma-glutamyl-L-cysteine synthetase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4146.89
Molecular mass(da)45795.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 432
	  		  	1    MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADP   60
			  	61   FRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSA  120
			  	121  LANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDA  180
			  	181  GPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGAS  240
			  	241  GDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYH  300
			  	301  LTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDT  360
			  	361  AARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGI  420
			  	421  ASAVTGMMHGAS

Known structures in the PDB
No Known structures
1 44 87 130 173 216 259 302 345 388 431 Range: 46 to 355  |  Coverage: 71% GCS2 Range: 21 to 426  |  Coverage: 93% 1 Range: 34 to 432  |  Coverage: 92% 1
Number of amino acids : 432
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GCS2PF0410746-355
Mtb Structural Proteome models
Model Number1
Model nameRv3704c
Template2GWD    APDBCREDO
Template coverage79_511
Template Identity(%)26.1
Model coverage(%)93.8
Normalized DOPE score-0.222

Structure Models from Chopin
Model Number1
Profiled.128.1.3
Click for model details
zscore28.28
Residue begin34
Residue end432
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3704cGene nameConfidence Score
Rv1878glnA30.975
Rv2222cglnA20.966
Rv2222cglnA20.966
Rv2860cglnA40.966
Rv2860cglnA40.966
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
gamma-glutamylcysteinePubChem0.956250.272
glutamatePubChem0.922147.129
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
phosphatePubChem0.996.9872
adenosine triphosphatePubChem0.9507.181
NSC647529PubChem0.9307.323
polyglycinePubChem0.975.0666
NSC319051PubChem0.9250.272
adenosine diphosphatePubChem0.9427.201
half-cystinePubChem0.9121.158
cysteinatePubChem0.9121.158
reduced glutathionePubChem0.9307.323
H(+)PubChem0.92.01588