Rv1161

Tuberculist information
Gene namenarG
Protein functionRespiratory nitrate reductase (alpha chain) NarG
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1287.33
Molecular mass(da)136924
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1232
	  		  	1    VTVTPHVGGPLEELLERSGRFFTPGEFSADLRTVTRRGGREGDVFYRDRWSHDKVVRSTH   60
			  	61   GVNCTGSCSWKIYVKDGIITWETQQTDYPSVGPDRPEYEPRGCPRGASFSWYSYSPTRVR  120
			  	121  YPYARGVLVEMYREAKTRLGDPVLAWADIQADPERRRRYQQARGKGGLVRVSWAEASEMV  180
			  	181  AAAHVHTIKTYGPDRVAGFSPIPAMSMVSHAAGSRFVELIGGVMTSFYDWYADLPVASPQ  240
			  	241  VFGDQTDVPESGDWWDASYLVMWGSNVPITRTPDAHWMAEARYRGAKVVVVSPDYADNTK  300
			  	301  FADEWVRCAAGTDTALAMAMGHVILSECYVRNQVPFFVDYVRRYTDLPFLIKLEKRGDLL  360
			  	361  VPGKFLTAADIGEESENAAFKPALLDELTNTVVVPQGSLGFRFGEDGVGKWNLDLGSVVP  420
			  	421  ALSVEMDKAVNGDRSAELVTLPSFDTIDGHGETVSRGVPVRRAGKHLVCTVFDLMLAHYG  480
			  	481  VARAGLPGEWPTGYHDRTQQNTPAWQESITGVPAAQAIRFAKEFARNATESGGRSMIIMG  540
			  	541  GGICHWFHSDVMYRSVLALLMLTGSMGRNGGGWAHYVGQEKVRPLTGWQTMAMATDWSRP  600
			  	601  PRQVPGASYWYAHTDQWRYDGYGADKLASPVGRGRFAGKHTMDLLTSATAMGWSPFYPQF  660
			  	661  DRSSLDVADEARAAGRDVGDYVAEQLAQHKLKLSITDPDNPVNWPRVLTVWRANLIGSSG  720
			  	721  KGGEYFLRHLLGTDSNVQSDPPTDGVHPRDVVWDSDIPEGKLDLIMSIDFRMTSTTLVSD  780
			  	781  VVLPAATWYEKSDLSSTDMHPYVHSFSPAIDPPWETRSDFDAFAAIARAFSALAKRHLGT  840
			  	841  RTDVVLTALQHDTPDEMAYPDGTERDWLATGEVPVPGRTMSKLTVVERDYTAIYDKWLTL  900
			  	901  GPLIDQFGMTTKGYTVHPFREVSELAANFGVMNSGVAVGRPAITTAKRMADVILALSGTC  960
			  	961  NGRLAVEGFLELEKRTGQRLAHLAEGSEERRITYADTQARPVPVITSPEWSGSESGGRRY 1020
			  	1021 APFTINIEHLKPFHTLTGRMHFYLAHDWVEELGEQLPVYRPPLDMARLFNQPELGPTDDG 1080
			  	1081 LGLTVRYLTPHSKWSFHSTYQDNLYMLSLSRGGPTMWMSPGDAAKINVRDNDWVEAVNAN 1140
			  	1141 GIYVCRAIVSHRMPEGVVFVYHVQERTVDTPRTETNGKRGGNHNALTRVRIKPSHLAGGY 1200
			  	1201 GQHAFAFNYLGPTGNQRDEVTVVRRRSQEVRY

Known structures in the PDB
No Known structures
1 124 247 370 493 616 739 862 985 1108 1231 Range: 53 to 115  |  Coverage: 5% Molybdop_Fe4S4 Range: 118 to 829  |  Coverage: 57% Molybdopterin Range: 1085 to 1205  |  Coverage: 9% Molydop_binding Range: 12 to 221  |  Coverage: 16% 1 Range: 1 to 1232  |  Coverage: 99% 1 Range: 303 to 652  |  Coverage: 28% 2 Range: 1045 to 1232  |  Coverage: 15% 3 Range: 138 to 512  |  Coverage: 30% 4 Range: 47 to 120  |  Coverage: 5% 5
Number of amino acids : 1232
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Molybdop_Fe4S4PF0487953-115
MolybdopterinPF00384118-829
Molydop_bindingPF015681085-1205
Mtb Structural Proteome models
Model Number1
Model nameRv1161
Template1Q16    APDBCREDO
Template coverage1_1232
Template Identity(%)46.5
Model coverage(%)99.0
Normalized DOPE score-0.956

Structure Models from Chopin
Model Number1
Profilec.81.1.1
Click for model details
zscore27.47
Residue begin1
Residue end1232
Model Number2
Profile3.40.228.10
Click for model details
zscore20.54
Residue begin303
Residue end652
Model Number3
Profileb.52.2.2
Click for model details
zscore19.88
Residue begin1045
Residue end1232
Model Number4
Profile3.40.50.740
Click for model details
zscore12.57
Residue begin138
Residue end512
Model Number5
Profile2.20.25.90
Click for model details
zscore11.15
Residue begin47
Residue end120
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1161Gene nameConfidence Score
Rv1162narH0.999
Rv1162narH0.999
Rv1163narJ0.999
Rv1164narI0.999
Rv0252nirB0.99
Rv0252nirB0.99
Rv0252nirB0.99
Rv0252nirB0.99
Rv0252nirB0.99
Rv1737cnarK20.989
Rv0267narU0.983
Rv2391sirA0.957
Rv2391sirA0.957
Rv0253nirD0.943
Rv0261cnarK30.937
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
nitratePubChem0.98762.0049
nitrous acidPubChem0.9346.0055
nitrite ionPubChem0.92546.0055
nitritePubChem0.782225.181