Rv1737c

Tuberculist information
Gene namenarK2
Protein functionPossible nitrate/nitrite transporter NarK2
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)1964.18
Molecular mass(da)41109.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 395
	  		  	1    MRGQAANLVLATWISVVNFWAWNLIGPLSTSYARDMSLSSAEASLLVATPILVGALGRIV   60
			  	61   TGPLTDRFGGRAMLIAVTLASILPVLAVGVAATMGSYALLVFFGLFLGVAGTIFAVGIPF  120
			  	121  ANNWYQPARRGFSTGVFGMGMVGTALSAFFTPRFVRWFGLFTTHAIVAAALASTAVVAMV  180
			  	181  VLRDAPYFRPNADPVLPRLKAAARLPVTWEMSFLYAIVFGGFVAFSNYLPTYITTIYGFS  240
			  	241  TVDAGARTAGFALAAVLARPVGGWLSDRIAPRHVVLASLAGTALLAFAAALQPPPEVWSA  300
			  	301  ATFITLAVCLGVGTGGVFAWVARRAPAASVGSVTGIVAAAGGLGGYFPPLVMGATYDPVD  360
			  	361  NDYTVGLLLLVATALVACTYTALHAREPVSEEASR

Known structures in the PDB
No Known structures
1 40 79 118 157 196 235 274 313 352 391 Range: 11 to 392  |  Coverage: 96% MFS_1 Range: 2 to 393  |  Coverage: 98% 1 Range: to   |  Coverage: 0% 1 Range: to   |  Coverage: 0% 2
Number of amino acids : 395
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MFS_1PF0769011-392
Mtb Structural Proteome models
Model Number1
Model nameRv1737c
Template1PW4    APDBCREDO
Template coverage25_443
Template Identity(%)14.3
Model coverage(%)99.0
Normalized DOPE score0.423

Structure Models from Chopin
Model Number1
Profilef.38.1.1
Click for model details
zscore27.35
Residue begin
Residue end
Model Number2
Profilef.38.1.2
Click for model details
zscore11.25
Residue begin
Residue end
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1737cGene nameConfidence Score
Rv1161narG0.989
Rv1161narG0.989
Rv1161narG0.989
Rv1736cnarX0.978
Rv1736cnarX0.978
Rv1736cnarX0.978
Rv1164narI0.973
Rv2329cnarK10.967
Rv1163narJ0.951
Rv1162narH0.944
Rv1162narH0.944
Rv0252nirB0.943
Rv0252nirB0.943
Rv0252nirB0.943
Rv0252nirB0.943
Rv0252nirB0.943
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
nitratePubChem0.83562.0049