Tuberculist information
Gene namemoeB1
Protein functionProbable molybdenum cofactor biosynthesis protein MoeB1 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3582.53
Molecular mass(da)42141.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 392
	  		  	1    VSTSLPPLVEPASALSREEVARYSRHLIIPDLGVDGQKRLKNARVLVIGAGGLGAPTLLY   60
			  	61   LAAAGVGTIGIVDFDVVDESNLQRQVIHGVADVGRSKAQSARDSIVAINPLIRVRLHELR  120
			  	121  LAPSNAVDLFKQYDLILDGTDNFATRYLVNDAAVLAGKPYVWGSIYRFEGQASVFWEDAP  180
			  	181  DGLGVNYRDLYPEPPPPGMVPSCAEGGVLGIICASVASVMGTEAIKLITGIGETLLGRLL  240
			  	241  VYDALEMSYRTITIRKDPSTPKITELVDYEQFCGVVADDAAQAAKGSTITPRELRDWLDS  300
			  	301  GRKLALIDVRDPVEWDIVHIDGAQLIPKSLINSGEGLAKLPQDRTAVLYCKTGVRSAEAL  360
			  	361  AAVKKAGFSDAVHLQGGIVAWAKQMQPDMVMY
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ThiFPF0089941-175
MoeZ_MoeBPF05237182-266
RhodanesePF00581290-384
Mtb Structural Proteome models
Model Number1
Model nameRv3206c.2
Template1GMX    APDBCREDO
Template coverage1_106
Template Identity(%)21.9
Model coverage(%)27.8
Normalized DOPE score-1.21

Model Number2
Model nameRv3206c
Template1JW9    BPDBCREDO
Template coverage2_247
Template Identity(%)37.2
Model coverage(%)63.8
Normalized DOPE score-0.541

Structure Models from Chopin
Model Number1
Profilec.111.1.1 - 3.40.50.720
Click for model details
zscore54.65
Residue begin13
Residue end264
Model Number2
Profilec.46.1.3 - 3.40.250.10
Click for model details
zscore20.57
Residue begin290
Residue end384
Model Number3
Profilec.46.1.3 - 3.40.250.10
Click for model details
zscore13.02
Residue begin265
Residue end392
Model Number4
Profilec.111.1.2
Click for model details
zscore9.68
Residue begin16
Residue end392
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3206cGene nameConfidence Score
Rv1335cysO0.997
Rv3323cmoaX0.983
Rv3323cmoaX0.983
Rv1336cysM0.967
Rv3025ciscS0.956
Rv3119moaE10.947
Rv0866moaE20.937
Rv3117cysA30.921
Rv0417thiG0.919
Rv0423cthiC0.907
Rv0423cthiC0.907
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv3206c.263gp0_NIL_A_1PDBCREDO0.6960.0840.6960.000
Rv3206c.261xkk_FMM_A_91PDBCREDO0.6870.0910.6690.001
Rv3206c.262qxs_RAL_A_600PDBCREDO0.7060.0760.6520.001
Rv3206c.262qxs_RAL_B_600PDBCREDO0.7030.0790.6490.001
Rv3206c.213heg_BAX_A_1PDBCREDO0.6870.0910.6460.001
Rv3206c.213gcs_BAX_A_401PDBCREDO0.7060.0760.6440.001
Rv3206c.263cs9_NIL_C_600PDBCREDO0.6470.1270.6300.001
Rv3206c.212jfa_RAL_B_600PDBCREDO0.6280.1470.6280.001
Rv3206c.211err_RAL_B_600PDBCREDO0.6260.1490.6260.001
Rv3206c.261t46_STI_A_3PDBCREDO0.6420.1320.6250.001
Rv3206c.211err_RAL_A_600PDBCREDO0.6250.1500.6250.001
Rv3206c.213hec_STI_A_1PDBCREDO0.6440.1300.6250.001
Rv3206c.263ufn_ROC_A_401PDBCREDO0.6230.1520.6230.001
Rv3206c.262xkw_P1B_A_1478PDBCREDO0.6560.1180.6230.001
Rv3206c.263cs9_NIL_D_600PDBCREDO0.6350.1400.6180.001
Rv3206c.214asd_BAX_A_1500PDBCREDO0.6760.1000.6180.002
Rv3206c.263cs9_NIL_B_600PDBCREDO0.6680.1070.6170.002
Rv3206c.212jfa_RAL_A_600PDBCREDO0.6360.1390.6160.002
Rv3206c.263cs9_NIL_A_600PDBCREDO0.6820.0950.6120.002
Rv3206c.212oiq_STI_A_1001PDBCREDO0.6510.1230.6120.002
Rv3206c.213oez_STI_B_601PDBCREDO0.6290.1460.6100.002
Rv3206c.263sm2_478_A_126PDBCREDO0.6480.1260.6000.002
Rv3206c.211xzx_T3_X_500PDBCREDO0.6380.1370.5990.002
Rv3206c.263gcs_BAX_A_401PDBCREDO0.7690.0380.5980.002
Rv3206c.211bsx_T3_A_1PDBCREDO0.6550.1190.5960.002
Rv3206c.211bsx_T3_B_2PDBCREDO0.6550.1190.5960.002
Rv3206c.212pl0_STI_A_200PDBCREDO0.6300.1450.5920.002
Rv3206c.213uvv_T3_A_501PDBCREDO0.6300.1450.5920.002
Rv3206c.263heg_BAX_A_1PDBCREDO0.7810.0320.5900.003
Rv3206c.212hyy_STI_B_600PDBCREDO0.6240.1510.5870.003
Rv3206c.213gws_T3_X_500PDBCREDO0.6450.1300.5860.003
Rv3206c.211qkn_RAL_A_600PDBCREDO0.6410.1330.5830.003
Rv3206c.212y6o_1N1_A_1892PDBCREDO0.6210.1550.5830.003
Rv3206c.211y0x_T44_X_500PDBCREDO0.5960.1840.5780.003
Rv3206c.213oez_STI_A_601PDBCREDO0.6670.1090.5740.003
Rv3206c.263b0w_DGX_B_1PDBCREDO0.6570.1170.5740.003
Rv3206c.261opj_STI_A_3PDBCREDO0.6380.1360.5730.003
Rv3206c.263el9_DR7_A_100PDBCREDO0.6040.1740.5730.003
Rv3206c.263ogq_AB1_A_200PDBCREDO0.6020.1770.5710.004
Rv3206c.261n49_RIT_B_301PDBCREDO0.6350.1390.5710.004
Rv3206c.261opj_STI_B_4PDBCREDO0.6350.1400.5700.004
Rv3206c.262qak_1UN_A_1001PDBCREDO0.6270.1480.5660.004
Rv3206c.261c6z_ROC_B_505PDBCREDO0.6260.1490.5660.004
Rv3206c.262q64_1UN_B_1001PDBCREDO0.6260.1490.5650.004
Rv3206c.262pyn_1UN_A_1001PDBCREDO0.6240.1510.5640.004
Rv3206c.261n49_RIT_D_401PDBCREDO0.6820.0950.5630.004
Rv3206c.264asd_BAX_A_1500PDBCREDO0.7230.0650.5630.004
Rv3206c.262pym_1UN_A_1001PDBCREDO0.6220.1540.5610.004
Rv3206c.213v5w_8PR_A_701PDBCREDO0.6170.1600.5610.004
Rv3206c.263oez_STI_A_601PDBCREDO0.6790.0980.5600.004
Rv3206c.263spk_TPV_B_100PDBCREDO0.6990.0820.5600.004
Rv3206c.212h79_T3_A_1PDBCREDO0.6370.1380.5600.004
Rv3206c.213bbt_FMM_D_91PDBCREDO0.6810.0960.5600.004
Rv3206c.212h77_T3_A_1PDBCREDO0.6570.1180.5590.004
Rv3206c.213spk_TPV_B_100PDBCREDO0.6300.1450.5590.004
Rv3206c.262q63_1UN_A_1001PDBCREDO0.6180.1580.5580.004
Rv3206c.213cs9_NIL_A_600PDBCREDO0.7020.0790.5560.005
Rv3206c.213spk_TPV_A_100PDBCREDO0.6530.1220.5550.005
Rv3206c.212hyy_STI_C_600PDBCREDO0.6440.1300.5550.005
Rv3206c.212hw2_RFP_A_1200PDBCREDO0.5720.2140.5550.005
Rv3206c.223jw3_TOP_A_208PDBCREDO0.6190.1570.5550.005
Rv3206c.261uwj_BAX_A_1723PDBCREDO0.6520.1230.5530.005
Rv3206c.262jfa_RAL_B_600PDBCREDO0.7780.0340.5530.005
Rv3206c.213ms9_STI_B_1PDBCREDO0.6410.1340.5520.005
Rv3206c.212hyy_STI_A_600PDBCREDO0.6400.1340.5520.005
Rv3206c.213mss_STI_B_1PDBCREDO0.6400.1340.5520.005
Rv3206c.213mss_STI_D_1PDBCREDO0.6400.1350.5510.005
Rv3206c.211uwh_BAX_A_1723PDBCREDO0.5680.2200.5510.005
Rv3206c.261c6y_MK1_B_524PDBCREDO0.5810.2030.5510.005
Rv3206c.212hyy_STI_D_600PDBCREDO0.6390.1360.5500.005
Rv3206c.211uwh_BAX_B_1723PDBCREDO0.5670.2200.5500.005
Rv3206c.261err_RAL_A_600PDBCREDO0.7730.0360.5500.005
Rv3206c.213k5v_STI_B_2PDBCREDO0.6370.1370.5490.005
Rv3206c.213mss_STI_A_1PDBCREDO0.6370.1380.5490.005
Rv3206c.213pyy_STI_B_4PDBCREDO0.6370.1380.5490.005
Rv3206c.213gvu_STI_A_1001PDBCREDO0.6360.1390.5480.005
Rv3206c.213ms9_STI_A_1PDBCREDO0.6360.1390.5480.005
Rv3206c.213mss_STI_C_1PDBCREDO0.6360.1390.5480.005
Rv3206c.213pyy_STI_A_3PDBCREDO0.6360.1390.5480.005
Rv3206c.211iep_STI_B_202PDBCREDO0.6350.1400.5470.005
Rv3206c.211xkk_FMM_A_91PDBCREDO0.7890.0290.5470.005
Rv3206c.211iep_STI_A_201PDBCREDO0.6350.1400.5470.005
Rv3206c.263el0_1UN_A_201PDBCREDO0.6260.1500.5460.005
Rv3206c.261err_RAL_B_600PDBCREDO0.7680.0380.5460.005
Rv3206c.213gp0_NIL_A_1PDBCREDO0.7680.0380.5460.005
Rv3206c.211fm6_BRL_X_504PDBCREDO0.5810.2030.5450.005
Rv3206c.211s9p_DES_A_459PDBCREDO0.7110.0730.5450.005
Rv3206c.263s56_ROC_A_201PDBCREDO0.5740.2110.5450.005
Rv3206c.213oht_1N1_B_1000PDBCREDO0.7100.0730.5450.005
Rv3206c.263ggu_017_B_201PDBCREDO0.5590.2320.5440.005
Rv3206c.211uwj_BAX_B_1723PDBCREDO0.5960.1840.5440.005
Rv3206c.212fum_MIX_D_3539PDBCREDO0.6610.1140.5440.006
Rv3206c.211sa1_POD_B_700PDBCREDO0.5950.1850.5430.006
Rv3206c.262oiq_STI_A_1001PDBCREDO0.7190.0670.5430.006
Rv3206c.213cs9_NIL_B_600PDBCREDO0.7050.0770.5430.006
Rv3206c.263bjw_SVR_E_503PDBCREDO0.5720.2140.5430.006
Rv3206c.212qxs_RAL_B_600PDBCREDO0.7040.0770.5420.006
Rv3206c.211zgy_BRL_A_503PDBCREDO0.6370.1370.5420.006
Rv3206c.263k5v_STI_A_2PDBCREDO0.6210.1550.5420.006
Rv3206c.261hxw_RIT_B_301PDBCREDO0.5550.2370.5410.006
Rv3206c.211sa1_POD_D_701PDBCREDO0.5750.2110.5400.006
Rv3206c.212qxs_RAL_A_600PDBCREDO0.7010.0800.5400.006
Rv3206c.261hsh_MK1_A_401PDBCREDO0.5690.2180.5400.006
Rv3206c.263ekq_ROC_A_100PDBCREDO0.5830.1990.5390.006
Rv3206c.211t7j_478_A_200PDBCREDO0.5550.2370.5380.006
Rv3206c.213erd_DES_B_800PDBCREDO0.7270.0620.5380.006
Rv3206c.262jfa_RAL_A_600PDBCREDO0.7800.0330.5370.006
Rv3206c.211s9p_DES_D_600PDBCREDO0.6990.0810.5370.006
Rv3206c.211opj_STI_A_3PDBCREDO0.6780.0990.5370.006
Rv3206c.213ogp_017_A_200PDBCREDO0.5680.2190.5350.006
Rv3206c.262fxd_DR7_A_102PDBCREDO0.5630.2260.5340.006
Rv3206c.263lzv_017_A_200PDBCREDO0.6120.1650.5340.006
Rv3206c.212xkw_P1B_B_1475PDBCREDO0.7210.0660.5340.007
Rv3206c.261ya4_CTX_A_1PDBCREDO0.6210.1550.5340.007
Rv3206c.263pyy_STI_B_4PDBCREDO0.6450.1300.5320.007
Rv3206c.261rl8_RIT_A_9001PDBCREDO0.6040.1750.5320.007
Rv3206c.211opj_STI_B_4PDBCREDO0.6720.1040.5320.007
Rv3206c.261sa1_POD_B_700PDBCREDO0.6830.0950.5310.007
Rv3206c.262nnk_ROC_A_401PDBCREDO0.6330.1420.5310.007
Rv3206c.211n49_RIT_D_401PDBCREDO0.6170.1590.5310.007
Rv3206c.263bjw_SVR_B_501PDBCREDO0.5450.2510.5310.007
Rv3206c.263rgf_BAX_A_465PDBCREDO0.6250.1500.5310.007
Rv3206c.213erd_DES_A_600PDBCREDO0.7170.0680.5310.007
Rv3206c.262pl0_STI_A_200PDBCREDO0.7010.0800.5290.007
Rv3206c.212o4n_TPV_A_300PDBCREDO0.5450.2510.5280.007
Rv3206c.263ndt_ROC_D_100PDBCREDO0.6290.1460.5280.007
Rv3206c.213k5v_STI_A_2PDBCREDO0.6490.1260.5280.007
Rv3206c.262hyy_STI_A_600PDBCREDO0.6390.1350.5280.007
Rv3206c.263mss_STI_A_1PDBCREDO0.6390.1350.5280.007
Rv3206c.263mss_STI_C_1PDBCREDO0.6390.1360.5270.007
Rv3206c.263mss_STI_D_1PDBCREDO0.6390.1360.5270.007
Rv3206c.263k5v_STI_B_2PDBCREDO0.6390.1360.5270.007
Rv3206c.262hyy_STI_C_600PDBCREDO0.6380.1370.5260.007
Rv3206c.213qt0_486_A_4PDBCREDO0.6390.1350.5260.007
Rv3206c.263ms9_STI_B_1PDBCREDO0.6370.1380.5260.007
Rv3206c.211d4y_TPV_A_501PDBCREDO0.5420.2560.5250.007
Rv3206c.261sdv_MK1_B_902PDBCREDO0.5390.2590.5250.007
Rv3206c.263ucb_017_A_201PDBCREDO0.6250.1500.5250.007
Rv3206c.263mss_STI_B_1PDBCREDO0.6360.1390.5250.007
Rv3206c.263pyy_STI_A_3PDBCREDO0.6360.1390.5250.007
Rv3206c.211uwj_BAX_A_1723PDBCREDO0.6270.1480.5250.007
Rv3206c.261iep_STI_A_201PDBCREDO0.6360.1390.5250.007
Rv3206c.263el4_ROC_A_100PDBCREDO0.6400.1350.5240.008
Rv3206c.263bjw_SVR_F_502PDBCREDO0.5380.2610.5240.008
Rv3206c.211t46_STI_A_3PDBCREDO0.7180.0680.5240.008
Rv3206c.263bjw_SVR_H_504PDBCREDO0.5380.2620.5240.008
Rv3206c.211uob_PNN_A_1311PDBCREDO0.5570.2350.5240.008
Rv3206c.261iep_STI_B_202PDBCREDO0.6340.1400.5240.008
Rv3206c.263gvu_STI_A_1001PDBCREDO0.6340.1400.5240.008
Rv3206c.263ms9_STI_A_1PDBCREDO0.6340.1400.5240.008
Rv3206c.262f80_017_B_301PDBCREDO0.5800.2040.5230.008
Rv3206c.261hsh_MK1_C_402PDBCREDO0.5520.2420.5230.008
Rv3206c.262hyy_STI_D_600PDBCREDO0.6340.1410.5230.008
Rv3206c.213cs9_NIL_C_600PDBCREDO0.7170.0690.5230.008
Rv3206c.261hxb_ROC_A_100PDBCREDO0.5790.2050.5230.008
Rv3206c.262r5p_MK1_B_902PDBCREDO0.5370.2630.5230.008
Rv3206c.261y0x_T44_X_500PDBCREDO0.7110.0720.5220.008
Rv3206c.223vkx_T3_A_301PDBCREDO0.6390.1360.5210.008
Rv3206c.262r5p_MK1_D_902PDBCREDO0.5350.2650.5210.008
Rv3206c.221pcg_EST_B_2PDBCREDO0.7010.0800.5210.008
Rv3206c.221qku_EST_C_600PDBCREDO0.7010.0800.5210.008
Rv3206c.221ere_EST_E_600PDBCREDO0.6980.0820.5190.008
Rv3206c.213cs9_NIL_D_600PDBCREDO0.7110.0720.5190.008
Rv3206c.213so9_017_A_100PDBCREDO0.5350.2650.5190.008
Rv3206c.262w8y_486_A_1000PDBCREDO0.6650.1100.5180.008
Rv3206c.213rgf_BAX_A_465PDBCREDO0.6180.1580.5170.008
Rv3206c.221ere_EST_A_600PDBCREDO0.6960.0840.5170.008
Rv3206c.221g50_EST_B_1600PDBCREDO0.6960.0840.5170.008
Rv3206c.221qku_EST_A_600PDBCREDO0.6960.0840.5170.008
Rv3206c.262fxe_DR7_A_102PDBCREDO0.5300.2720.5170.008
Rv3206c.263eky_DR7_A_100PDBCREDO0.5300.2730.5160.009
Rv3206c.213e22_LOC_B_700PDBCREDO0.5320.2690.5160.009
Rv3206c.221ere_EST_B_600PDBCREDO0.6940.0850.5160.009
Rv3206c.221qku_EST_B_600PDBCREDO0.6940.0850.5160.009
Rv3206c.261sa1_POD_D_701PDBCREDO0.6820.0950.5160.009
Rv3206c.263uvv_T3_A_501PDBCREDO0.7730.0360.5160.009
Rv3206c.263em4_DR7_V_100PDBCREDO0.5290.2740.5150.009
Rv3206c.213e22_LOC_D_700PDBCREDO0.5320.2700.5150.009
Rv3206c.263k4v_ROC_D_201PDBCREDO0.6430.1310.5150.009
Rv3206c.221gwr_EST_B_600PDBCREDO0.6930.0860.5150.009
Rv3206c.213vn2_TLS_A_501PDBCREDO0.5140.2970.5140.009
Rv3206c.221gwr_EST_A_600PDBCREDO0.6910.0870.5140.009
Rv3206c.263kk6_CEL_B_1701PDBCREDO0.5560.2350.5140.009
Rv3206c.261xzx_T3_X_500PDBCREDO0.7680.0380.5130.009
Rv3206c.262hyy_STI_B_600PDBCREDO0.6780.0990.5120.009
Rv3206c.261sh9_RIT_B_301PDBCREDO0.5400.2580.5120.009
Rv3206c.261k6c_MK1_B_902PDBCREDO0.6240.1510.5110.009
Rv3206c.263em4_DR7_A_100PDBCREDO0.5390.2600.5110.009
Rv3206c.221g50_EST_C_2600PDBCREDO0.7840.0310.5100.009
Rv3206c.261uwj_BAX_B_1723PDBCREDO0.6550.1200.5100.009
Rv3206c.223ret_SAL_B_201PDBCREDO0.5380.2620.5090.009
Rv3206c.263h52_486_A_3PDBCREDO0.6950.0850.5090.009
Rv3206c.213b0w_DGX_B_1PDBCREDO0.6250.1510.5080.010
Rv3206c.263pwr_ROC_A_401PDBCREDO0.5910.1900.5080.010
Rv3206c.222j7x_EST_A_1454PDBCREDO0.7810.0320.5080.010
Rv3206c.221a52_EST_A_1PDBCREDO0.7800.0330.5070.010
Rv3206c.221qkt_EST_A_600PDBCREDO0.7800.0330.5070.010
Rv3206c.212w8y_486_A_1000PDBCREDO0.5540.2380.5060.010
Rv3206c.221ere_EST_C_600PDBCREDO0.7780.0340.5060.010
Rv3206c.221ere_EST_D_600PDBCREDO0.7780.0340.5060.010
Rv3206c.221pcg_EST_A_1PDBCREDO0.7780.0340.5060.010
Rv3206c.263ogp_017_B_200PDBCREDO0.6120.1650.5050.010
Rv3206c.221ere_EST_F_600PDBCREDO0.7770.0340.5050.010
Rv3206c.223hm1_J3Z_B_1PDBCREDO0.7770.0340.5050.010
Rv3206c.223hgx_SAL_B_104PDBCREDO0.5330.2680.5050.010
Rv3206c.221xbb_STI_A_1PDBCREDO0.5890.1930.5050.010
Rv3206c.263h52_486_B_1PDBCREDO0.6680.1070.5050.010
Rv3206c.211d4s_TPV_A_201PDBCREDO0.5920.1890.5040.010
Rv3206c.223fl9_TOP_E_200PDBCREDO0.5620.2280.5040.010
Rv3206c.223fl9_TOP_F_200PDBCREDO0.5620.2280.5040.010
Rv3206c.213h52_486_A_3PDBCREDO0.5190.2890.5030.010
Rv3206c.213h52_486_D_2PDBCREDO0.5190.2890.5030.010
Rv3206c.262b60_RIT_B_100PDBCREDO0.5020.3160.5020.011
Rv3206c.221a52_EST_B_2PDBCREDO0.7710.0370.5010.011
Rv3206c.261uwh_BAX_B_1723PDBCREDO0.6830.0940.5010.011
Rv3206c.212xkw_P1B_A_1478PDBCREDO0.7410.0530.5000.011
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions