Rv2155c

Tuberculist information
Gene namemurD
Protein functionProbable UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2414.93
Molecular mass(da)49313.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 486
	  		  	1    VLDPLGPGAPVLVAGGRVTGQAVAAVLTRFGATPTVCDDDPVMLRPHAERGLPTVSSSDA   60
			  	61   VQQITGYALVVASPGFSPATPLLAAAAAAGVPIWGDVELAWRLDAAGCYGPPRSWLVVTG  120
			  	121  TNGKTTTTSMLHAMLIAGGRRAVLCGNIGSAVLDVLDEPAELLAVELSSFQLHWAPSLRP  180
			  	181  EAGAVLNIAEDHLDWHATMAEYTAAKARVLTGGVAVAGLDDSRAAALLDGSPAQVRVGFR  240
			  	241  LGEPAARELGVRDAHLVDRAFSDDLTLLPVASIPVPGPVGVLDALAAAALARSVGVPAGA  300
			  	301  IADAVTSFRVGRHRAEVVAVADGITYVDDSKATNPHAARASVLAYPRVVWIAGGLLKGAS  360
			  	361  LHAEVAAMASRLVGAVLIGRDRAAVAEALSRHAPDVPVVQVVAGEDTGMPATVEVPVACV  420
			  	421  LDVAKDDKAGETVGAAVMTAAVAAARRMAQPGDTVLLAPAGASFDQFTGYADRGEAFATA  480
			  	481  VRAVIR

Known structures in the PDB
No Known structures
1 49 97 145 193 241 289 337 385 433 481 Range: 118 to 291  |  Coverage: 35% Mur_ligase_M Range: 311 to 389  |  Coverage: 16% Mur_ligase_C Range: 8 to 484  |  Coverage: 97% 1 Range: 1 to 486  |  Coverage: 99% 1 Range: 118 to 291  |  Coverage: 35% 2 Range: 2 to 97  |  Coverage: 19% 3 Range: 309 to 486  |  Coverage: 36% 4 Range: 311 to 389  |  Coverage: 16% 5 Range: 79 to 311  |  Coverage: 47% 6
Number of amino acids : 486
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Mur_ligase_MPF08245118-291
Mur_ligase_CPF02875311-389
Mtb Structural Proteome models
Model Number1
Model nameRv2155c
Template4UAG    APDBCREDO
Template coverage5_436
Template Identity(%)32.6
Model coverage(%)97.9
Normalized DOPE score0.898

Structure Models from Chopin
Model Number1
Profile3.40.1190.10, 3.40.50.720, 3.90.190.20
Click for model details
zscore42.64
Residue begin1
Residue end486
Model Number2
Profilec.72.2.1
Click for model details
zscore26.83
Residue begin118
Residue end291
Model Number3
Profilec.5.1.1
Click for model details
zscore14.33
Residue begin2
Residue end97
Model Number4
Profilec.59.1.1
Click for model details
zscore13.93
Residue begin309
Residue end486
Model Number5
Profile3.90.190.20
Click for model details
zscore10.48
Residue begin311
Residue end389
Model Number6
Profilec.72.2.2
Click for model details
zscore8.68
Residue begin79
Residue end311
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2155cGene nameConfidence Score
Rv2153cmurG0.999
Rv2153cmurG0.999
Rv2158cmurE0.999
Rv2154cftsW0.999
Rv2158cmurE0.999
Rv2156cmurX0.999
Rv2158cmurE0.999
Rv2156cmurX0.999
Rv2152cmurC0.998
Rv2152cmurC0.998
Rv2152cmurC0.998
Rv0017crodA0.997
Rv2150cftsZ0.996
Rv2157cmurF0.996
Rv2150cftsZ0.996
Rv2157cmurF0.996
Rv0482murB0.996
Rv0482murB0.996
Rv2157cmurF0.996
Rv2981cddlA0.995
Rv2981cddlA0.995
Rv1315murA0.994
Rv1338murI0.985
Rv2163cpbpB0.983
Rv2163cpbpB0.983
Rv2165cRv2165c0.971
Rv2166cRv2166c0.964
Rv2151cftsQ0.961
Rv2151cftsQ0.961
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
UDP-N-acetylmuramoyl-L-alaninePubChem0.981750.494
glutamatePubChem0.96147.129
D-glutamatePubChem0.958147.129
UDP-MurNAcPubChem0.956679.416
adenosine diphosphatePubChem0.956427.201
UAGPubChem0.953879.608
meso-diaminopimelatePubChem0.922190.197
phosphatePubChem0.91796.9872
diaminopimelic acidPubChem0.913190.197
L-alaninePubChem0.90689.0932
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
adenosine triphosphatePubChem0.9507.181
C04877PubChem0.91051.79
sulfatePubChem0.8196.0626
chloridePubChem0.79535.453
hydron sulfatePubChem0.736196.157