Rv2152c

Tuberculist information
Gene namemurC
Protein functionProbable UDP-N-acetylmuramate-alanine ligase MurC
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2410.64
Molecular mass(da)51144.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 494
	  		  	1    VSTEQLPPDLRRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESRGVHALRARGALIRI   60
			  	61   GHDASSLDLLPGGATAVVTTHAAIPKTNPELVEARRRGIPVVLRPAVLAKLMAGRTTLMV  120
			  	121  TGTHGKTTTTSMLIVALQHCGLDPSFAVGGELGEAGTNAHHGSGDCFVAEADESDGSLLQ  180
			  	181  YTPHVAVITNIESDHLDFYGSVEAYVAVFDSFVERIVPGGALVVCTDDPGGAALAQRATE  240
			  	241  LGIRVLRYGSVPGETMAATLVSWQQQGVGAVAHIRLASELATAQGPRVMRLSVPGRHMAL  300
			  	301  NALGALLAAVQIGAPADEVLDGLAGFEGVRRRFELVGTCGVGKASVRVFDDYAHHPTEIS  360
			  	361  ATLAAARMVLEQGDGGRCMVVFQPHLYSRTKAFAAEFGRALNAADEVFVLDVYGAREQPL  420
			  	421  AGVSGASVAEHVTVPMRYVPDFSAVAQQVAAAASPGDVIVTMGAGDVTLLGPEILTALRV  480
			  	481  RANRSAPGRPGVLG

Known structures in the PDB
No Known structures
1 50 99 148 197 246 295 344 393 442 491 Range: 12 to 116  |  Coverage: 21% Mur_ligase Range: 120 to 309  |  Coverage: 38% Mur_ligase_M Range: 329 to 423  |  Coverage: 19% Mur_ligase_C Range: 8 to 476  |  Coverage: 94% 1 Range: 4 to 485  |  Coverage: 97% 1 Range: 120 to 309  |  Coverage: 38% 2 Range: 327 to 490  |  Coverage: 32% 3 Range: 4 to 105  |  Coverage: 20% 4 Range: 1 to 334  |  Coverage: 67% 5
Number of amino acids : 494
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Mur_ligasePF0122512-116
Mur_ligase_MPF08245120-309
Mur_ligase_CPF02875329-423
Mtb Structural Proteome models
Model Number1
Model nameRv2152c
Template1P3D    APDBCREDO
Template coverage13_471
Template Identity(%)37.9
Model coverage(%)94.7
Normalized DOPE score-0.473

Structure Models from Chopin
Model Number1
Profilec.5.1.1, c.59.1.1, c.72.2.1 - 3.40.1190.10, 3.40.50.720, 3.90.190.20
Click for model details
zscore60.44
Residue begin4
Residue end485
Model Number2
Profile3.40.1190.10
Click for model details
zscore27.83
Residue begin120
Residue end309
Model Number3
Profilec.59.1.1
Click for model details
zscore20.72
Residue begin327
Residue end490
Model Number4
Profilec.5.1.1
Click for model details
zscore16.84
Residue begin4
Residue end105
Model Number5
Profile3.40.1190.10
Click for model details
zscore12.74
Residue begin1
Residue end334
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2152cGene nameConfidence Score
Rv2156cmurX0.999
Rv0482murB0.999
Rv2156cmurX0.999
Rv2153cmurG0.999
Rv0482murB0.999
Rv2153cmurG0.999
Rv2155cmurD0.998
Rv2155cmurD0.998
Rv2154cftsW0.995
Rv2158cmurE0.99
Rv2158cmurE0.99
Rv2158cmurE0.99
Rv2157cmurF0.99
Rv2157cmurF0.99
Rv2157cmurF0.99
Rv2981cddlA0.989
Rv2981cddlA0.989
Rv1315murA0.979
Rv2150cftsZ0.978
Rv2150cftsZ0.978
Rv2163cpbpB0.976
Rv2163cpbpB0.976
Rv0017crodA0.969
Rv2151cftsQ0.96
Rv2151cftsQ0.96
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
UDP-N-acetylmuramoyl-L-alaninePubChem0.971750.494
L-alaninePubChem0.96389.0932
UDP-N-acetylglucosamine enolpyruvatePubChem0.958677.4
UDP-MurNAcPubChem0.958679.416
D-glutamatePubChem0.9147.129
NADPPubChem0.9744.413
protiumPubChem0.92.01576
phosphatePubChem0.996.9872
adenosine triphosphatePubChem0.9507.181
glutamatePubChem0.9147.129
H(+)PubChem0.92.01588
NADP(H)PubChem0.9745.421
adenosine diphosphatePubChem0.9427.201
UAGPubChem0.9879.608
deuteriumPubChem0.92.01588
selenomethioninePubChem0.789196.106
SeMetPubChem0.789196.106
magnesiumPubChem0.73224.305