Rv1315

Tuberculist information
Gene namemurA
Protein functionProbable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)1470.32
Molecular mass(da)44031.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 418
	  		  	1    VAERFVVTGGNRLSGEVAVGGAKNSVLKLMAATLLAEGTSTITNCPDILDVPLMAEVLRG   60
			  	61   LGATVELDGDVARITAPDEPKYDADFAAVRQFRASVCVLGPLVGRCKRARVALPGGDAIG  120
			  	121  SRPLDMHQAGLRQLGAHCNIEHGCVVARAETLRGAEIQLEFPSVGATENILMAAVVAEGV  180
			  	181  TTIHNAAREPDVVDLCTMLNQMGAQVEGAGSPTMTITGVPRLHPTEHRVIGDRIVAATWG  240
			  	241  IAAAMTRGDISVAGVDPAHLQLVLHKLHDAGATVTQTDASFRVTQYERPKAVNVATLPFP  300
			  	301  GFPTDLQPMAIALASIADGTSMITENVFEARFRFVEEMIRLGADARTDGHHAVVRGLPQL  360
			  	361  SSAPVWCSDIRAGAGLVLAGLVADGDTEVHDVFHIDRGYPLFVENLVSLGAEIERVCC

Known structures in the PDB
No Known structures
1 42 83 124 165 206 247 288 329 370 411 Range: 7 to 406  |  Coverage: 95% EPSP_synthase Range: 2 to 417  |  Coverage: 99% 1 Range: 1 to 418  |  Coverage: 99% 1 Range: 68 to 296  |  Coverage: 54% 2
Number of amino acids : 418
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
EPSP_synthasePF002757-406
Mtb Structural Proteome models
Model Number1
Model nameRv1315
Template1EJD    APDBCREDO
Template coverage1_417
Template Identity(%)43.5
Model coverage(%)99.3
Normalized DOPE score-1.086

Structure Models from Chopin
Model Number1
Profiled.68.2.2 - 3.65.10.10
Click for model details
zscore49.93
Residue begin1
Residue end418
Model Number2
Profile3.65.10.10
Click for model details
zscore12.87
Residue begin68
Residue end296
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1315Gene nameConfidence Score
Rv0482murB0.999
Rv0482murB0.999
Rv2155cmurD0.994
Rv2155cmurD0.994
Rv2153cmurG0.994
Rv2153cmurG0.994
Rv2158cmurE0.993
Rv2158cmurE0.993
Rv2158cmurE0.993
Rv2981cddlA0.99
Rv2981cddlA0.99
Rv1018cglmU0.988
Rv1018cglmU0.988
Rv2150cftsZ0.982
Rv2150cftsZ0.982
Rv2152cmurC0.979
Rv2152cmurC0.979
Rv2152cmurC0.979
Rv2154cftsW0.966
Rv2157cmurF0.963
Rv2157cmurF0.963
Rv2157cmurF0.963
Rv1689tyrS0.962
Rv1689tyrS0.962
Rv2163cpbpB0.941
Rv2163cpbpB0.941
Rv0017crodA0.935
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00828DrugBankFosfomycin
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
UDP-GlcNAcPubChem0.994607.354
UDP-N-acetylglucosamine enolpyruvatePubChem0.991677.4
phosphatePubChem0.98496.9872
phosphoenolpyruvatePubChem0.978168.042
fosfomycinPubChem0.966138.059
UDP-MurNAcPubChem0.949679.416
H(+)PubChem0.9032.01588
deuteriumPubChem0.9032.01588
NADP(H)PubChem0.9745.421
protiumPubChem0.92.01576
NADPPubChem0.9744.413
hydron diphosphatePubChem0.787391.981
phosphitePubChem0.7678.972
GG6PubChem0.704156.074
hydron sulfatePubChem0.704196.157
sulfatePubChem0.70496.0626