Rv2163c

Tuberculist information
Gene namepbpB
Protein functionProbable penicillin-binding membrane protein PbpB
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2425.05
Molecular mass(da)72504.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 679
	  		  	1    VSRAAPRRASQSQSTRPARGLRRPPGAQEVGQRKRPGKTQKARQAQEATKSRPATRSDVA   60
			  	61   PAGRSTRARRTRQVVDVGTRGASFVFRHRTGNAVILVLMLVAATQLFFLQVSHAAGLRAQ  120
			  	121  AAGQLKVTDVQPAARGSIVDRNNDRLAFTIEARALTFQPKRIRRQLEEARKKTSAAPDPQ  180
			  	181  QRLRDIAQEVAGKLNNKPDAAAVLKKLQSDETFVYLARAVDPAVASAICAKYPEVGAERQ  240
			  	241  DLRQYPGGSLAANVVGGIDWDGHGLLGLEDSLDAVLAGTDGSVTYDRGSDGVVIPGSYRN  300
			  	301  RHKAVHGSTVVLTLDNDIQFYVQQQVQQAKNLSGAHNVSAVVLDAKTGEVLAMANDNTFD  360
			  	361  PSQDIGRQGDKQLGNPAVSSPFEPGSVNKIVAASAVIEHGLSSPDEVLQVPGSIQMGGVT  420
			  	421  VHDAWEHGVMPYTTTGVFGKSSNVGTLMLSQRVGPERYYDMLRKFGLGQRTGVGLPGESA  480
			  	481  GLVPPIDQWSGSTFANLPIGQGLSMTLLQMTGMYQAIANDGVRVPPRIIKATVAPDGSRT  540
			  	541  EEPRPDDIRVVSAQTAQTVRQMLRAVVQRDPMGYQQGTGPTAGVPGYQMAGKTGTAQQIN  600
			  	601  PGCGCYFDDVYWITFAGIATADNPRYVIGIMLDNPARNSDGAPGHSAAPLFHNIAGWLMQ  660
			  	661  RENVPLSPDPGPPLVLQAT

Known structures in the PDB
No Known structures
1 68 135 202 269 336 403 470 537 604 671 Range: 130 to 298  |  Coverage: 24% PBP_dimer Range: 338 to 656  |  Coverage: 46% Transpeptidase Range: 123 to 679  |  Coverage: 81% 1 Range: 208 to 312  |  Coverage: 15% 2 Range: 170 to 312  |  Coverage: 20% 3 Range: 309 to 672  |  Coverage: 53% 4 Range: 20 to 74  |  Coverage: 7% 5
Number of amino acids : 679
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PBP_dimerPF03717130-298
TranspeptidasePF00905338-656
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
Model Number1
Profiled.11.1.1, d.175.1.1, e.3.1.1
Click for model details
zscore53.09
Residue begin123
Residue end679
Model Number2
Profile3.90.1310.10
Click for model details
zscore19.33
Residue begin208
Residue end312
Model Number3
Profiled.175.1.1
Click for model details
zscore17.47
Residue begin170
Residue end312
Model Number4
Profile3.40.710.10
Click for model details
zscore13.6
Residue begin309
Residue end672
Model Number5
Profile1.20.5.450
Click for model details
zscore4.72
Residue begin20
Residue end74
Binding pockets
Structure models not available for this query
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2163cGene nameConfidence Score
Rv2153cmurG0.999
Rv2153cmurG0.999
Rv2165cRv2165c0.994
Rv2154cftsW0.993
Rv2158cmurE0.992
Rv2158cmurE0.992
Rv2158cmurE0.992
Rv0017crodA0.988
Rv2155cmurD0.983
Rv2155cmurD0.983
Rv2164cRv2164c0.977
Rv2152cmurC0.976
Rv2152cmurC0.976
Rv2152cmurC0.976
Rv2166cRv2166c0.974
Rv2156cmurX0.97
Rv2156cmurX0.97
Rv2150cftsZ0.964
Rv2150cftsZ0.964
Rv2981cddlA0.955
Rv2981cddlA0.955
Rv2157cmurF0.952
Rv2157cmurF0.952
Rv2157cmurF0.952
Rv1315murA0.941
Rv0482murB0.923
Rv0482murB0.923
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00267DrugBankCefmenoxime
DB00274DrugBankCefmetazole
DB00303DrugBankErtapenem
DB00319DrugBankPiperacillin
DB00355DrugBankAztreonam
DB00415DrugBankAmpicillin
DB00417DrugBankPenicillin V
DB00430DrugBankCefpiramide
DB00438DrugBankCeftazidime
DB00456DrugBankCefalotin
DB00485DrugBankDicloxacillin
DB00493DrugBankCefotaxime
DB00535DrugBankCefdinir
DB00567DrugBankCephalexin
DB00607DrugBankNafcillin
DB00671DrugBankCefixime
DB00713DrugBankOxacillin
DB00739DrugBankHetacillin
DB00923DrugBankCeforanide
DB00948DrugBankMezlocillin
DB01000DrugBankCyclacillin
DB01053DrugBankPenicillin G
DB01066DrugBankCefditoren
DB01140DrugBankCefadroxil
DB01147DrugBankCloxacillin
DB01150DrugBankCefprozil
DB01163DrugBankAmdinocillin
DB01212DrugBankCeftriaxone
DB01326DrugBankCefamandole
DB01327DrugBankCefazolin
DB01328DrugBankCefonicid
DB01329DrugBankCefoperazone
DB01331DrugBankCefoxitin
DB01332DrugBankCeftizoxime
DB01413DrugBankCefepime
DB01415DrugBankCeftibuten
DB01416DrugBankCefpodoxime
DB01598DrugBankImipenem
DB01603DrugBankMeticillin
DB01607DrugBankTicarcillin
DB04570DrugBankLatamoxef
DB08795DrugBankAzidocillin
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C05898PubChem0.91920.24
lipid intermediate IIPubChem0.91920.24
penicillinPubChem0.807334.39
hydron sulfatePubChem0.728196.157
sulfatePubChem0.72896.0626
cephalexinPubChem0.72347.389
piperacillinPubChem0.718516.547
ceftriaxonePubChem0.715552.564
glycerolPubChem0.70992.0938