Rv2153c

Tuberculist information
Gene namemurG
Protein functionProbable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2412.12
Molecular mass(da)41828.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 410
	  		  	1    VKDTVSQPAGGRGATAPRPADAASPSCGSSPSADSVSVVLAGGGTAGHVEPAMAVADALV   60
			  	61   ALDPRVRITALGTLRGLETRLVPQRGYHLELITAVPMPRKPGGDLARLPSRVWRAVREAR  120
			  	121  DVLDDVDADVVVGFGGYVALPAYLAARGLPLPPRRRRRIPVVIHEANARAGLANRVGAHT  180
			  	181  ADRVLSAVPDSGLRRAEVVGVPVRASIAALDRAVLRAEARAHFGFPDDARVLLVFGGSQG  240
			  	241  AVSLNRAVSGAAADLAAAGVCVLHAHGPQNVLELRRRAQGDPPYVAVPYLDRMELAYAAA  300
			  	301  DLVICRAGAMTVAEVSAVGLPAIYVPLPIGNGEQRLNALPVVNAGGGMVVADAALTPELV  360
			  	361  ARQVAGLLTDPARLAAMTAAAARVGHRDAAGQVARAALAVATGAGARTTT

Known structures in the PDB
No Known structures
1 42 83 124 165 206 247 288 329 370 411 Range: 38 to 186  |  Coverage: 36% Glyco_transf_28 Range: 231 to 393  |  Coverage: 39% Glyco_tran_28_C Range: 36 to 403  |  Coverage: 89% 1 Range: 36 to 404  |  Coverage: 89% 1
Number of amino acids : 410
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Glyco_transf_28PF0303338-186
Glyco_tran_28_CPF04101231-393
Mtb Structural Proteome models
Model Number1
Model nameRv2153c
Template1F0K    APDBCREDO
Template coverage7_356
Template Identity(%)38.0
Model coverage(%)89.5
Normalized DOPE score-0.059

Structure Models from Chopin
Model Number1
Profilec.87.1.2
Click for model details
zscore54.9
Residue begin36
Residue end404
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2153cGene nameConfidence Score
Rv2163cpbpB0.999
Rv2157cmurF0.999
Rv2154cftsW0.999
Rv2157cmurF0.999
Rv2155cmurD0.999
Rv2158cmurE0.999
Rv2155cmurD0.999
Rv2158cmurE0.999
Rv2156cmurX0.999
Rv2152cmurC0.999
Rv2158cmurE0.999
Rv2156cmurX0.999
Rv2152cmurC0.999
Rv2163cpbpB0.999
Rv2157cmurF0.999
Rv2152cmurC0.999
Rv0017crodA0.997
Rv2150cftsZ0.996
Rv2150cftsZ0.996
Rv0482murB0.995
Rv0482murB0.995
Rv1315murA0.994
Rv0016cpbpA0.991
Rv2981cddlA0.987
Rv2981cddlA0.987
Rv2151cftsQ0.963
Rv2151cftsQ0.963
Rv2911dacB20.935
Rv3627cRv3627c0.926
Rv3330dacB10.914
Rv2165cRv2165c0.913
Rv2166cRv2166c0.911
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
UDP-GlcNAcPubChem0.981607.354
undecaprenyl-pyrophosphoryl-MurNAc-pentapeptidePubChem0.9811717.05
lipid IPubChem0.9521673.04
lipid intermediate IIPubChem0.9391920.24
H(+)PubChem0.92.01588
protiumPubChem0.92.01576
undecaprenyl pyrophosphatePubChem0.9927.262
C04851PubChem0.91673.04
C05898PubChem0.91920.24
undecaprenyl phosphatePubChem0.9847.282
undecaprenyl diphosphatePubChem0.9927.262
deuteriumPubChem0.92.01588
uridine diphosphatePubChem0.9404.161
C05897PubChem0.91717.05
polyuridylic acidPubChem0.9324.181
C04882PubChem0.91193.95
tunicamycinPubChem0.746718.703