Rv2157c

Tuberculist information
Gene namemurF
Protein functionProbable UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2417.47
Molecular mass(da)51632.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 510
	  		  	1    MIELTVAQIAEIVGGAVADISPQDAAHRRVTGTVEFDSRAIGPGGLFLALPGARADGHDH   60
			  	61   AASAVAAGAAVVLAARPVGVPAIVVPPVAAPNVLAGVLEHDNDGSGAAVLAALAKLATAV  120
			  	121  AAQLVAGGLTIIGITGSSGKTSTKDLMAAVLAPLGEVVAPPGSFNNELGHPWTVLRATRR  180
			  	181  TDYLILEMAARHHGNIAALAEIAPPSIGVVLNVGTAHLGEFGSREVIAQTKAELPQAVPH  240
			  	241  SGAVVLNADDPAVAAMAKLTAARVVRVSRDNTGDVWAGPVSLDELARPRFTLHAHDAQAE  300
			  	301  VRLGVCGDHQVTNALCAAAVALECGASVEQVAAALTAAPPVSRHRMQVTTRGDGVTVIDD  360
			  	361  AYNANPDSMRAGLQALAWIAHQPEATRRSWAVLGEMAELGEDAIAEHDRIGRLAVRLDVS  420
			  	421  RLVVVGTGRSISAMHHGAVLEGAWGSGEATADHGADRTAVNVADGDAALALLRAELRPGD  480
			  	481  VVLVKASNAAGLGAVADALVADDTCGSVRP

Known structures in the PDB
No Known structures
1 52 103 154 205 256 307 358 409 460 511 Range: 31 to 121  |  Coverage: 17% Mur_ligase Range: 134 to 321  |  Coverage: 36% Mur_ligase_M Range: 341 to 434  |  Coverage: 18% Mur_ligase_C Range: 1 to 499  |  Coverage: 97% 1 Range: 134 to 321  |  Coverage: 36% 1
Number of amino acids : 510
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Mur_ligasePF0122531-121
Mur_ligase_MPF08245134-321
Mur_ligase_CPF02875341-434
Mtb Structural Proteome models
Model Number1
Model nameRv2157c
Template1GG4    APDBCREDO
Template coverage1_446
Template Identity(%)34.7
Model coverage(%)97.6
Normalized DOPE score0.795

Structure Models from Chopin
Model Number1
Profilec.72.2.1
Click for model details
zscore26.38
Residue begin134
Residue end321
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2157cGene nameConfidence Score
Rv2158cmurE0.999
Rv2153cmurG0.999
Rv2158cmurE0.999
Rv2158cmurE0.999
Rv2156cmurX0.999
Rv2156cmurX0.999
Rv2153cmurG0.999
Rv2981cddlA0.998
Rv2981cddlA0.998
Rv2154cftsW0.997
Rv2155cmurD0.996
Rv2155cmurD0.996
Rv2152cmurC0.99
Rv2152cmurC0.99
Rv2152cmurC0.99
Rv0482murB0.987
Rv0482murB0.987
Rv0017crodA0.984
Rv2150cftsZ0.982
Rv2150cftsZ0.982
Rv3423calr0.979
Rv3423calr0.979
Rv1315murA0.963
Rv2163cpbpB0.952
Rv2163cpbpB0.952
Rv2151cftsQ0.931
Rv2151cftsQ0.931
Rv2166cRv2166c0.91
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
UDP-MurNAc-pentapeptidePubChem0.91149.94
diaminopimelic acidPubChem0.9190.197
C04702PubChem0.91149.94
UAGPubChem0.9879.608
adenosine triphosphatePubChem0.9507.181
polyuridylic acidPubChem0.9324.181
H(+)PubChem0.92.01588
D-Ala-D-AlaPubChem0.9160.171
meso-diaminopimelatePubChem0.9190.197
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
phosphatePubChem0.996.9872
adenosine diphosphatePubChem0.9427.201
C04877PubChem0.91051.79
dialaninePubChem0.9160.171
C04882PubChem0.91193.95
undecaprenyl phosphatePubChem0.9847.282
D-alaninePubChem0.989.0932
L-alaninePubChem0.989.0932
SeMetPubChem0.757196.106
selenomethioninePubChem0.757196.106