Rv3585

Tuberculist information
Gene nameradA
Protein functionDNA repair protein RadA (DNA repair protein SMS)
Functional category(tuberculist)information pathways
Gene location(kb)4026.44
Molecular mass(da)49881
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 480
	  		  	1    VANARSQYRCSECRHVSAKWVGRCLECGRWGTVDEVAVLSAVGGTRRRSVAPASGAVPIS   60
			  	61   AVDAHRTRPCPTGIDELDRVLGGGIVPGSVTLLAGDPGVGKSTLLLEVAHRWAQSGRRAL  120
			  	121  YVSGEESAGQIRLRADRIGCGTEVEEIYLAAQSDVHTVLDQIETVQPALVIVDSVQTMST  180
			  	181  SEADGVTGGVTQVRAVTAALTAAAKANEVALILVGHVTKDGAIAGPRSLEHLVDVVLHFE  240
			  	241  GDRNGALRMVRGVKNRFGAADEVGCFLLHDNGIDGIVDPSNLFLDQRPTPVAGTAITVTL  300
			  	301  DGKRPLVGEVQALLATPCGGSPRRAVSGIHQARAAMIAAVLEKHARLAIAVNDIYLSTVG  360
			  	361  GMRLTEPSADLAVAIALASAYANLPLPTTAVMIGEVGLAGDIRRVNGMARRLSEAARQGF  420
			  	421  TIALVPPSDDPVPPGMHALRASTIVAALQYMVDIADHRGTTLATPPSHSGTGHVPLGRGT  480

Known structures in the PDB
No Known structures
1 49 97 145 193 241 289 337 385 433 481 Range: 57 to 222  |  Coverage: 34% AAA_25 Range: 315 to 429  |  Coverage: 23% ChlI Range: 32 to 274  |  Coverage: 50% 1 Range: 30 to 312  |  Coverage: 58% 2 Range: 63 to 460  |  Coverage: 82% 3 Range: 315 to 429  |  Coverage: 23% 1 Range: 285 to 458  |  Coverage: 36% 2 Range: 57 to 222  |  Coverage: 34% 3
Number of amino acids : 480
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AAA_25PF1348157-222
ChlIPF13541315-429
Mtb Structural Proteome models
Model Number1
Model nameRv3585.2
Template1XP8    APDBCREDO
Template coverage15_282
Template Identity(%)18.8
Model coverage(%)50.4
Normalized DOPE score-0.256

Model Number2
Model nameRv3585.1
Template1G19    APDBCREDO
Template coverage1_306
Template Identity(%)18.4
Model coverage(%)58.8
Normalized DOPE score0.174

Model Number3
Model nameRv3585
Template1TF7    APDBCREDO
Template coverage14_449
Template Identity(%)13.6
Model coverage(%)82.7
Normalized DOPE score0.736

Structure Models from Chopin
Model Number1
Profiled.14.1.10 - 3.30.230.10
Click for model details
zscore13.45
Residue begin315
Residue end429
Model Number2
Profiled.14.1.10 - 3.30.230.10
Click for model details
zscore10.8
Residue begin285
Residue end458
Model Number3
Profilec.37.1.11 - 3.40.50.300
Click for model details
zscore9.2
Residue begin57
Residue end222
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3585Gene nameConfidence Score
Rv3586Rv35860.975
Rv3586Rv35860.975
Rv3586Rv35860.975
Rv2720lexA0.973
Rv2720lexA0.973
Rv0058dnaB0.933
Rv0058dnaB0.933
Rv0058dnaB0.933
Rv0058dnaB0.933
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv3585.241xkk_FMM_A_91PDBCREDO0.7700.0370.5290.007
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Target nameCHEMBL IDSMILES
Rad51COC(=O)c1cccc2[nH]ccc12
Rad51Cc1cc2nc3c(nc2cc1C)[C@]4(CCC3(C)C4(C)C)C(=O)O
Rad51O=C1N(Cc2ccccc2)C(=Nc3ccccc13)C=Cc4cccnc4
Rad51c1n[nH]c2ccccc12
Rad51Oc1ccc2ccccc2c1
Rad51Oc1ccc2[nH]ccc2c1
Rad51Nc1nc2ccccc2s1
Rad51COC(=O)[C@@H](N)Cc1c[nH]c2ccccc12
Rad51Cc1ccc2[nH]ccc2c1
Rad51Oc1cccc2ccccc12
STITCH interactions  
No high confidence interactions