Rv3586

Tuberculist information
Gene nameRv3586
Protein functionConserved hypothetical protein
Functional category(tuberculist)conserved hypotheticals
Gene location(kb)4027.89
Molecular mass(da)39031.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 358
	  		  	1    MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRY   60
			  	61   AATRLRELCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPV  120
			  	121  ISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLERYKTRLDEVSRQLSRAEIEDF  180
			  	181  VTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYH  240
			  	241  ANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSTLSPRGYRAMAGI  300
			  	301  PRLQFAHADLLVRAFGTLQGLLAASAGDLQSVDGIGAMWARHVREGLSQLAESTISDQ

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 22 to 139  |  Coverage: 32% DisA_N Range: 141 to 289  |  Coverage: 41% DisA-linker Range: 295 to 354  |  Coverage: 16% HHH_2 Range: 17 to 142  |  Coverage: 34% 1 Range: 286 to 344  |  Coverage: 16% 2 Range: 22 to 139  |  Coverage: 32% 1 Range: 295 to 354  |  Coverage: 16% 2 Range: 276 to 356  |  Coverage: 22% 3 Range: 1 to 358  |  Coverage: 99% 4
Number of amino acids : 358
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DisA_NPF0245722-139
DisA-linkerPF10635141-289
HHH_2PF12826295-354
Mtb Structural Proteome models
Model Number1
Model nameRv3586
Template2FB5    APDBCREDO
Template coverage75_204
Template Identity(%)21.4
Model coverage(%)34.9
Normalized DOPE score-1.576

Model Number2
Model nameRv3586.2
Template1X2I    APDBCREDO
Template coverage2_60
Template Identity(%)30.5
Model coverage(%)16.2
Normalized DOPE score-1.038

Structure Models from Chopin
Model Number1
Profiled.320.1.1
Click for model details
zscore24.93
Residue begin22
Residue end139
Model Number2
Profilea.60.2.5
Click for model details
zscore12.84
Residue begin295
Residue end354
Model Number3
Profilea.60.2.5
Click for model details
zscore8.55
Residue begin276
Residue end356
Model Number4
Profilea.60.2.2, b.40.4.6, d.142.2.2 - 1.10.150.20, 1.10.287.610, 2.40.50.140, 3.30.1490.70, 3.30.470.30
Click for model details
zscore7.45
Residue begin1
Residue end358
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3586Gene nameConfidence Score
Rv3585radA0.975
Rv3585radA0.975
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv3586.222wd9_IBP_A_1570PDBCREDO0.5790.2060.5440.006
Rv3586.223jw3_TOP_B_208PDBCREDO0.5680.2190.5350.006
Rv3586.223hgx_SAL_A_102PDBCREDO0.6700.1050.5320.007
Rv3586.223hgx_SAL_B_104PDBCREDO0.6700.1050.5320.007
Rv3586.223ret_SAL_A_201PDBCREDO0.6700.1050.5320.007
Rv3586.223ret_SAL_B_201PDBCREDO0.6590.1160.5230.008
Rv3586.223ug2_IRE_A_1PDBCREDO0.8110.0210.5220.008
Rv3586.223jw3_TOP_A_208PDBCREDO0.6060.1720.5080.010
Rv3586.221uay_ADN_B_1002PDBCREDO0.5640.2240.5010.011
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions