Rv3370c

Tuberculist information
Gene namednaE2
Protein functionProbable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase)
Functional category(tuberculist)information pathways
Gene location(kb)3781.5
Molecular mass(da)116484
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1079
	  		  	1    MERVLNGKPRHAGVPAFDADGDVPRSRKRGAYQPPGRERVGSSVAYAELHAHSAYSFLDG   60
			  	61   ASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLGATARTER  120
			  	121  PDPPGPHLLVLARGPEGYRRLSRQLAAAHLAGGEKGKPRYDFDALTEAAGGHWHILTGCR  180
			  	181  KGHVRQALSQGGPAAAQRALADLVDRFTPSRVSIELTHHGHPLDDERNAALAGLAPRFGV  240
			  	241  GIVATTGAHFADPSRGRLAMAMAAIRARRSLDSAAGWLAPLGGAHLRSGEEMARLFAWCP  300
			  	301  EAVTAAAELGERCAFGLQLIAPRLPPFDVPDGHTEDSWLRSLVMAGARERYGPPKSAPRA  360
			  	361  YSQIEHELKVIAQLRFPGYFLVVHDITRFCRDNDILCQGRGSAANSAVCYALGVTAVDPV  420
			  	421  ANELLFERFLSPARDGPPDIDIDIESDQREKVIQYVYHKYGRDYAAQVANVITYRGRSAV  480
			  	481  RDMARALGFSPGQQDAWSKQVSHWTGQADDVDGIPEQVIDLATQIRNLPRHLGIHSGGMV  540
			  	541  ICDRPIADVCPVEWARMANRSVLQWDKDDCAAIGLVKFDLLGLGMLSALHYAKDLVAEHK  600
			  	601  GIEVDLARLDLSEPAVYEMLARADSVGVFQVESRAQMATLPRLKPRVFYDLVVEVALIRP  660
			  	661  GPIQGGSVHPYIRRRNGVDPVIYEHPSMAPALRKTLGVPLFQEQLMQLAVDCAGFSAAEA  720
			  	721  DQLRRAMGSKRSTERMRRLRGRFYDGMRALHGAPDEVIDRIYEKLEAFANFGFPESHALS  780
			  	781  FASLVFYSAWFKLHHPAAFCAALLRAQPMGFYSPQSLVADARRHGVAVHGPCVNASLAHA  840
			  	841  TCENAGTEVRLGLGAVRYLGAELAEKLVAERTANGPFTSLPDLTSRVQLSVPQVEALATA  900
			  	901  GALGCFGMSRREALWAAGAAATGRPDRLPGVGSSSHIPALPGMSELELAAADVWATGVSP  960
			  	961  DSYPTQFLRADLDAMGVLPAERLGSVSDGDRVLIAGAVTHRQRPATAQGVTFINLEDETG 1020
			  	1021 MVNVLCTPGVWARHRKLAHTAPALLIRGQVQNASGAITVVAERMGRLTLAVGARSRDFR

Known structures in the PDB
No Known structures
1 108 215 322 429 536 643 750 857 964 1071 Range: 47 to 229  |  Coverage: 16% PHP Range: 337 to 751  |  Coverage: 38% DNA_pol3_alpha Range: 825 to 914  |  Coverage: 8% HHH_6 Range: 992 to 1067  |  Coverage: 6% tRNA_anti-codon Range: 47 to 295  |  Coverage: 22% 1 Range: 42 to 295  |  Coverage: 23% 1 Range: 952 to 1075  |  Coverage: 11% 2
Number of amino acids : 1079
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PHPPF0281147-229
DNA_pol3_alphaPF07733337-751
HHH_6PF14579825-914
tRNA_anti-codonPF01336992-1067
Mtb Structural Proteome models
Model Number1
Model nameRv3370c
Template1M65    APDBCREDO
Template coverage4_245
Template Identity(%)18.5
Model coverage(%)23.0
Normalized DOPE score0.561

Structure Models from Chopin
Model Number1
Profilec.6.3.1 - 3.20.20.140
Click for model details
zscore16.61
Residue begin42
Residue end295
Model Number2
Profileb.40.4.1
Click for model details
zscore8.16
Residue begin952
Residue end1075
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3370cGene nameConfidence Score
Rv2720lexA0.99
Rv2720lexA0.99
Rv1537dinX0.989
Rv1537dinX0.989
Rv1537dinX0.989
Rv3394cRv3394c0.98
Rv3394cRv3394c0.98
Rv3721cdnaZX0.962
Rv3721cdnaZX0.962
Rv3395cRv3395c0.953
Rv3056dinP0.95
Rv3056dinP0.95
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
thymidine triphosphatePubChem0.9482.168
deoxycytidine triphosphatePubChem0.9467.157
pyrophosphatePubChem0.9177.975
deoxyadenosine triphosphatePubChem0.9491.182
deoxyguanosine triphosphatePubChem0.9507.181