Rv1537

Tuberculist information
Gene namedinX
Protein functionProbable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed))
Functional category(tuberculist)information pathways
Gene location(kb)1739.86
Molecular mass(da)49075.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 463
	  		  	1    VLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARAYGARSAMPMHQARR   60
			  	61   LIGVTAVVLPPRGVVYGIASRRVFDTVRGLVPVVEQLSFDEAFAEPPQLAGAVAEDVETF  120
			  	121  CERLRRRVRDETGLIASVGAGSGKQIAKIASGLAKPDGIRVVRHAEEQALLSGLPVRRLW  180
			  	181  GIGPVAEEKLHRLGIETIGQLAALSDAEAANILGATIGPALHRLARGIDDRPVVERAEAK  240
			  	241  QISAESTFAVDLTTMEQLHEAIDSIAEHAHQRLLRDGRGARTITVKLKKSDMSTLTRSAT  300
			  	301  MPYPTTDAGALFTVARRLLPDPLQIGPIRLLGVGFSGLSDIRQESLFADSDLTQETAAAH  360
			  	361  YVETPGAVVPAAHDATMWRVGDDVAHPELGHGWVQGAGHGVVTVRFETRGSGPGSARTFP  420
			  	421  VDTGDISNASPLDSLDWPDYIGQLSVEGSAGASAPTVDDVGDR

Known structures in the PDB
No Known structures
1 47 93 139 185 231 277 323 369 415 461 Range: 4 to 152  |  Coverage: 31% IMS Range: 164 to 195  |  Coverage: 6% IMS_HHH Range: 230 to 347  |  Coverage: 25% IMS_C Range: 1 to 336  |  Coverage: 72% 1 Range: 1 to 341  |  Coverage: 73% 1 Range: 4 to 152  |  Coverage: 31% 2 Range: 1 to 239  |  Coverage: 51% 3 Range: 239 to 350  |  Coverage: 23% 4 Range: 1 to 463  |  Coverage: 99% 5
Number of amino acids : 463
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
IMSPF008174-152
IMS_HHHPF11798164-195
IMS_CPF11799230-347
Mtb Structural Proteome models
Model Number1
Model nameRv1537
Template1JX4    APDBCREDO
Template coverage3_338
Template Identity(%)29.5
Model coverage(%)72.4
Normalized DOPE score0.142

Structure Models from Chopin
Model Number1
Profiled.240.1.1, e.8.1.7 - 1.10.150.20, 3.30.1490.100, 3.30.70.270
Click for model details
zscore45.13
Residue begin1
Residue end341
Model Number2
Profilee.8.1.7
Click for model details
zscore43.85
Residue begin4
Residue end152
Model Number3
Profilee.8.1.7
Click for model details
zscore36.09
Residue begin1
Residue end239
Model Number4
Profiled.240.1.1 - 3.30.1490.100
Click for model details
zscore23.42
Residue begin239
Residue end350
Model Number5
Profiled.240.1.1, e.8.1.7 - 1.10.150.20, 3.30.1490.100
Click for model details
zscore19.96
Residue begin1
Residue end463
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1537Gene nameConfidence Score
Rv3370cdnaE20.989
Rv3370cdnaE20.989
Rv3370cdnaE20.989
Rv3370cdnaE20.989
Rv2720lexA0.952
Rv2720lexA0.952
Rv3056dinP0.929
Rv3056dinP0.929
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions