Rv1547

Tuberculist information
Gene namednaE1
Protein functionProbable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase)
Functional category(tuberculist)information pathways
Gene location(kb)1747.69
Molecular mass(da)129323
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1184
	  		  	1    MSGSSAGSSFVHLHNHTEYSMLDGAAKITPMLAEVERLGMPAVGMTDHGNMFGASEFYNS   60
			  	61   ATKAGIKPIIGVEAYIAPGSRFDTRRILWGDPSQKADDVSGSGSYTHLTMMAENATGLRN  120
			  	121  LFKLSSHASFEGQLSKWSRMDAELIAEHAEGIIITTGCPSGEVQTRLRLGQDREALEAAA  180
			  	181  KWREIVGPDNYFLELMDHGLTIERRVRDGLLEIGRALNIPPLATNDCHYVTRDAAHNHEA  240
			  	241  LLCVQTGKTLSDPNRFKFDGDGYYLKSAAEMRQIWDDEVPGACDSTLLIAERVQSYADVW  300
			  	301  TPRDRMPVFPVPDGHDQASWLRHEVDAGLRRRFPAGPPDGYRERAAYEIDVICSKGFPSY  360
			  	361  FLIVADLISYARSAGIRVGPGRGSAAGSLVAYALGITDIDPIPHGLLFERFLNPERTSMP  420
			  	421  DIDIDFDDRRRGEMVRYAADKWGHDRVAQVITFGTIKTKAALKDSARIHYGQPGFAIADR  480
			  	481  ITKALPPAIMAKDIPLSGITDPSHERYKEAAEVRGLIETDPDVRTIYQTARGLEGLIRNA  540
			  	541  GVHACAVIMSSEPLTEAIPLWKRPQDGAIITGWDYPACEAIGLLKMDFLGLRNLTIIGDA  600
			  	601  IDNVRANRGIDLDLESVPLDDKATYELLGRGDTLGVFQLDGGPMRDLLRRMQPTGFEDVV  660
			  	661  AVIALYRPGPMGMNAHNDYADRKNNRQAIKPIHPELEEPLREILAETYGLIVYQEQIMRI  720
			  	721  AQKVASYSLARADILRKAMGKKKREVLEKEFEGFSDGMQANGFSPAAIKALWDTILPFAD  780
			  	781  YAFNKSHAAGYGMVSYWTAYLKANYPAEYMAGLLTSVGDDKDKAAVYLADCRKLGITVLP  840
			  	841  PDVNESGLNFASVGQDIRYGLGAVRNVGANVVGSLLQTRNDKGKFTDFSDYLNKIDISAC  900
			  	901  NKKVTESLIKAGAFDSLGHARKGLFLVHSDAVDSVLGTKKAEALGQFDLFGSNDDGTGTA  960
			  	961  DPVFTIKVPDDEWEDKHKLALEREMLGLYVSGHPLNGVAHLLAAQVDTAIPAILDGDVPN 1020
			  	1021 DAQVRVGGILASVNRRVNKNGMPWASAQLEDLTGGIEVMFFPHTYSSYGADIVDDAVVLV 1080
			  	1081 NAKVAVRDDRIALIANDLTVPDFSNAEVERPLAVSLPTRQCTFDKVSALKQVLARHPGTS 1140
			  	1141 QVHLRLISGDRITTLALDQSLRVTPSPALMGDLKELLGPGCLGS

Known structures in the PDB
No Known structures
1 119 237 355 473 591 709 827 945 1063 1181 Range: 11 to 208  |  Coverage: 16% PHP Range: 319 to 762  |  Coverage: 37% DNA_pol3_alpha Range: 835 to 924  |  Coverage: 7% HHH_6 Range: 1024 to 1101  |  Coverage: 6% tRNA_anti-codon Range: 6 to 274  |  Coverage: 22% 1 Range: 1024 to 1101  |  Coverage: 6% 2
Number of amino acids : 1184
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PHPPF0281111-208
DNA_pol3_alphaPF07733319-762
HHH_6PF14579835-924
tRNA_anti-codonPF013361024-1101
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
Model Number1
Profilec.6.3.1 - 3.20.20.140
Click for model details
zscore9
Residue begin6
Residue end274
Model Number2
Profileb.40.4.1
Click for model details
zscore8.3
Residue begin1024
Residue end1101
Binding pockets
Structure models not available for this query
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1547Gene nameConfidence Score
Rv1617pykA0.988
Rv1617pykA0.988
Rv3721cdnaZX0.967
Rv3721cdnaZX0.967
Rv1629polA0.965
Rv1629polA0.965
Rv1629polA0.965
Rv0002dnaN0.957
Rv0002dnaN0.957
Rv0002dnaN0.957
Rv2344cdgt0.934
Rv2344cdgt0.934
Rv0006gyrA0.932
Rv0006gyrA0.932
Rv2445cndkA0.93
Rv0058dnaB0.93
Rv0058dnaB0.93
Rv0058dnaB0.93
Rv0058dnaB0.93
Rv2720lexA0.929
Rv2720lexA0.929
Rv2839cinfB0.92
Rv2839cinfB0.92
Rv2839cinfB0.92
Rv2839cinfB0.92
Rv0003recF0.918
Rv0321dcd0.914
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
thymidine triphosphatePubChem0.9482.168
deoxyadenosine triphosphatePubChem0.9491.182
deoxyguanosine triphosphatePubChem0.9507.181
deoxycytidine triphosphatePubChem0.9467.157